Sleep apnea hypopnea hypoventilation syndrome simulation animal model device and method

Abstract

The invention discloses a sleep apnea hypopnea hypoventilation syndrome animal model device and method. The sleep apnea hypopnea hypoventilation syndrome animal model device comprises a cabin body, amain control module, a sleep deprivation model device and an intermittent combined hypoxia and hypercapnia model device; the intermittent combined hypoxia and hypercapnia model device comprises at least two gas sources, one gas source is carbon dioxide gas, and the other gas source is air or oxygen; the main control module is used for controlling the oxygen concentration and the carbon dioxide concentration in the cabin body by controlling the gas supply states of the two gas sources according to the acquired oxygen concentration data and the acquired carbon dioxide gas concentration data, sothat intermittent combined hypoxia and hypercapnia is simulated; and meanwhile, the main control module also controls the sleep deprivation model device to cooperate to complete simultaneous simulation of intermittent combined hypoxia and hypercapniain a sleep deprivation state. The superposition of the three model factors can be closer to the pathophysiological mechanism for simulating the humanobstructive sleep apnea hypopnea hypoventilation syndrome.

Description

technical field [0001] The invention belongs to the technical field of laboratory equipment, in particular to the technical field of animal model devices. In particular, it relates to a method and an animal model device suitable for simulating sleep apnea hypopnea syndrome. Background technique [0002] About one-third of a person's life is spent in sleep, and sleep is one of the most basic physiological functions to maintain life activities. In recent years, with increasing social pressure, accelerated pace of life, and changes in dietary structure, the incidence of sleep disorders is increasing year by year. Studies have shown that as many as 15%-30% of adults suffer from sleep disorders for a long time. Among them, obstructive sleep apnea hypopnea syndrome (OSAHS) is the most common chronic sleep-breathing disease. Clinical studies have shown that obstructive sleep apnea-hypopnea syndrome (OSAHS) is a chronic sleep-breathing disorder with a relatively high incidence, w...

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Problems solved by technology

[0007] Most of the traditional OSAHS animal models only simulate intermittent hypoxia factors or a single sleep deprivation factor, and it is difficult to achieve the goal of simulating the pathophysiological mechanism of OSAHS as realistically as possible

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