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Artemisinic acid magnetic imprinting microspheres and preparation method and application thereof

A kind of artemisinic acid and magnetic technology, applied in other chemical processes, chemical instruments and methods, alkali metal oxides/hydroxides, etc., can solve the problems of complex polymerization process and rare raw materials, etc., and achieve large specific surface area and high adsorption Ability, ease of separation effect

Active Publication Date: 2016-08-17
南通新咏纺织科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional bulk polymerization is gradually replaced by new polymerization methods such as perfluorinated medium suspension polymerization, seed polymerization and graft polymerization, but most of these methods have defects such as complicated polymerization process and rare raw materials.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0013] The artemisinic acid magnetically imprinted microspheres and their preparation and use are described in detail below.

[0014] (1) Preparation of Fe3O4 magnetic nanoparticles: Dissolve 15mmol FeCl3·6H2O in 80mL deionized water, pass N2 for 20min for deoxygenation, continue to pass N2 and add 10mmol FeCl2·4H2O while stirring at 35°C, the solution turns yellow after fully mixing, and stir While dripping 50mL of 5% ammonia water, the resulting black solution was aged in a water bath at 60°C for 1h, collected Fe3O4 nanoparticles with a magnet, washed repeatedly with deionized water until the eluent was neutral, dried in vacuum at 40°C for 2h, and set aside;

[0015] (2) Preparation of molecularly imprinted polymers: 0.15 mmol of initiator AIBN, 5.0 mmol of mixed cross-linking agent TRIM-DVB (molar ratio 2:1) and 0.1 mL of oleic acid were dissolved in 1.5 mL of toluene solvent, and mixed thoroughly to prepare an oil Phase; Weigh 100mg of magnetic Fe3O4 nanoparticles and add ...

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PUM

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Abstract

The invention discloses a preparation method and application of artemisinic acid magnetic imprinting microspheres. Artemisinic acid serves as a template molecule, artemisinin serves as an auxiliary template, a magnetic Fe3O4 nano particle serves as a carrier, 4-vinylpyridine serves as a functional monomer, a TRIM-DVB mixture serves as a cross-linking agent, a surface imprinting technology is adopted, and the artemisinic acid magnetic imprinting microspheres are prepared; the obtained molecularly imprinting polymer particles are uniform in size, large in specific area and high in imprinting efficiency, the maximum static apparent adsorption amount of the imprinting microspheres for artemisinic acid is high, the artemisinic acid magnetic imprinting microspheres serve as adsorbent, enriched adsorbent can be selected from artemisia annua linn extract efficiently, the adsorbent can be rapidly separated through a magnet, washing and elution are conducted with solvent, a target compound can be separated, the recovery rate of artemisinic acid is 96.7%, and the product purity obtained after removal of solvent is higher than 80%. A novel separation material and method are provided for separation and purity of the bio active substance, namely artemisinic acid, in the artemisia annua linn.

Description

technical field [0001] The invention relates to an artemisinic acid magnetically imprinted microsphere, a preparation method and application thereof. Background technique [0002] Artemisinic acid is the precursor of artemisinin and its derivatives, belonging to sesquiterpenoids. Artemisinic acid has anti-tumor, anti-malarial and regulation of adipocyte differentiation. Sun Weichen et al found that artemisinic acid has a selective killing effect on human liver cancer cells SMMC-7721. Zhou Shengwei found that artemisinic acid can significantly inhibit cell proliferation. Deng Ding'an and others found that artemisinic acid and its derivatives have anti-tumor activity and have a killing effect on leukemia cell P338. Jongsung Lee et al. found that artemisinic acid can inhibit the expression level of C / EBPδ, and can inhibit obesity to a certain extent. Artemisinic acid is mainly extracted from the plant Artemisia annua. my country's Artemisia annua resources are very rich, e...

Claims

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Application Information

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IPC IPC(8): B01J20/26B01J20/28B01J20/30C08F212/36C08F226/06
CPCB01J20/268B01J20/28009B01J20/28021B01J20/28057C08F212/36C08F226/06
Inventor 李辉张月王素素龚梦婷陈功锡
Owner 南通新咏纺织科技有限公司
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