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A kind of tiamulin fumarate soluble powder and preparation method thereof

A tiamulin fumarate and soluble technology is applied in the field of tiamulin fumarate soluble powder and its preparation, which can solve the problems of tiamulin fumarate irritating odor, etc., and achieve mature recycling technology, cheap and easy-to-obtain raw materials, The effect of maintaining a high degree of stability

Active Publication Date: 2018-05-18
HEBEI TIANYUAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problems in the prior art, the present invention provides a tiamulin fumarate soluble powder with easy operation, high efficiency and low production cost, which can solve the problem of tiamulin fumarate irritating odor and its preparation method

Method used

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  • A kind of tiamulin fumarate soluble powder and preparation method thereof
  • A kind of tiamulin fumarate soluble powder and preparation method thereof
  • A kind of tiamulin fumarate soluble powder and preparation method thereof

Examples

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Effect test

Embodiment 1

[0023] Example 1, a soluble powder of tiamulin fumarate, comprising: 52.4% of tiamulin fumarate, 40% of β-cyclodextrin, 0.2% of sodium lauryl sulfate, 1.4% of EDTA, filler Agent 6%.

[0024] The preparation method includes the following steps: Step 1. Add the β-cyclodextrin into distilled water according to the mass percentage, and make it completely swell in a water bath at 55°C to prepare a saturated solution of β-cyclodextrin , namely solution A;

[0025] Step 2. Dissolving the said tiamulin fumarate in ethanol with a concentration above 95% according to the mass percentage, wherein the mass ratio of tiamulin fumarate to ethanol is 1:0.1 to obtain solution B;

[0026] Step 3. Slowly drop solution B into solution A in a water bath at 55°C at a constant speed, and stir for 6 hours to fully clathrate to obtain clathrate C;

[0027] Step 4. Cool the clathrate solution C to normal temperature, and quickly add ethanol with a concentration of more than 95% to the clathrate solut...

Embodiment 2

[0030] Embodiment 2, a kind of tiamulin fumarate soluble powder, comprises: tiamulin fumarate 32.6%, β-cyclodextrin 55%, sodium lauryl sulfate 0.6%, EDTA 1.8%, filler Agent 10%.

[0031] The preparation method includes the following steps: Step 1. Add the β-cyclodextrin to distilled water according to the mass percentage, and make it completely swell in a water bath at 65°C to prepare a saturated solution of β-cyclodextrin , namely solution A;

[0032] Step 2, according to the mass percentage, the described tiamulin fumarate is dissolved in ethanol with a concentration of 95% or more, wherein the mass ratio of tiamulin fumarate and ethanol is 1: 0.2 to obtain solution B;

[0033] Step 3. Slowly drop solution B into solution A in a water bath at 65°C, and stir for 5.5 hours to fully clathrate to obtain clathrate C;

[0034] Step 4. Cool the clathrate solution C to normal temperature, and quickly add ethanol with a concentration of more than 95% to the clathrate solution C, wh...

Embodiment 3

[0037] Embodiment 3, a kind of tiamulin fumarate soluble powder, comprises: tiamulin fumarate 45%, β-cyclodextrin 45%, sodium lauryl sulfate 0.4%, EDTA 1.6%, filler Agent 8%.

[0038] The preparation method includes the following steps: Step 1. Add the β-cyclodextrin into distilled water according to the mass percentage, and make it completely swell in a water bath at 55°C to prepare a saturated solution of β-cyclodextrin , namely solution A;

[0039] Step 2. Dissolving the said tiamulin fumarate in ethanol with a concentration above 95% according to the mass percentage, wherein the mass ratio of tiamulin fumarate to ethanol is 1:0.11 to obtain solution B;

[0040] Step 3. Slowly drop solution B into solution A in a water bath at 55°C at a constant speed, and stir for 6 hours to fully clathrate to obtain clathrate C;

[0041] Step 4. Cool the clathrate solution C to normal temperature, and quickly add ethanol with a concentration of more than 95% to the clathrate solution C,...

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Abstract

The invention provides soluble powder with tiamulin hydrogen famarate. The soluble powder comprises, by weight, 30-55% of the tiamulin hydrogen famarate, 30-55% of beta-cyclodextrin, 0.2-0.6% of sodium dodecyl sulfate, 1.4-1.8% of EDTA (ethylene diamine tetraacetic acid) and 6-10% of fillers. The soluble powder with the tiamulin hydrogen famarate has the advantages that problems of high viscosity of main medicines and difficulty in squeezing and rounding the main medicines due to technologies for granulating tiamulin hydrogen famarate by the aid of wet processes can be effectively solved by the aid of a method for preparing the soluble powder with the tiamulin hydrogen famarate; irritating odor of the tiamulin hydrogen famarate can be concealed by the prepared soluble powder with the tiamulin hydrogen famarate, and accordingly the medication compliance of animals can be improved; the soluble powder is uniform in particle size distribution, high in high-temperature and high-humidity resistance and good in stability and can withstand southern high-temperature and high-humidity environments while the high stability of the soluble powder is kept.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, and in particular relates to a tiamulin fumarate soluble powder and a preparation method thereof. Background technique [0002] Tiamulin (tiamulin, thiamutin, dynamutilin), also known as tiamulin, tiamulin, tiamulin, Zhiyuanjing, tiamulin, was originally a patented product of the Swiss Novartis company, and most of the actual use is tiamulin Bacterine fumarate. Tiamulin is an animal-specific antibiotic. Its antibacterial effect is to inhibit the synthesis of susceptible bacterial proteins and act on the ribosomes in the bacteria. Tiamulin has special effects on a variety of Gram-positive bacteria and Mycoplasma, especially on Staphylococcus aureus, Streptococcus, various molds and some spirochetes. Tiamulin is used to prevent and treat diseases caused by mycoplasma infection, Escherichia coli, Salmonella, spirochete and other infections. It has special effects on swine mycoplasma pne...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/22A61K9/14A61K47/61A61P31/04A61P11/00
CPCA61K9/146A61K31/22
Inventor 张晓燕王军海
Owner HEBEI TIANYUAN PHARMA CO LTD
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