Tiamulin fumarate granule and preparation method thereof

A technology of tiamulin fumarate and granules, which is applied in the directions of antibacterial drugs, pharmaceutical formulations, and medical preparations with inactive ingredients, etc. The effect of increasing feeding rate, reducing moisture absorption, and increasing stability

Active Publication Date: 2018-03-13
SHANGHAI TONGREN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the above-mentioned shortcoming in the prior art, provide a kind of can solve traditional tiamulin fumarate viscous, the soft material that prepares is relatively viscous, is difficult to be extruded and spheronized problem and can solve particle belt Miaobectin fumarate with pungent odor problem and preparation method thereof

Method used

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  • Tiamulin fumarate granule and preparation method thereof
  • Tiamulin fumarate granule and preparation method thereof
  • Tiamulin fumarate granule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Weigh each raw material with the following mass percentage (take the total amount as 100g as an example):

[0035]

[0036] Grind and sieve tiamulin fumarate, binders and fillers, mix them evenly, then pour into a boiling granulator and spray pure water into granules, then dry the plain granules; spray the coating solution, and After drying, take out and pass through a 30-60 mesh sieve; finally obtain the finished product of tiamulin fumarate granules.

[0037] Conditions for boiling granulation: the pure water used is 60%, the fan frequency is 15Hz, the air inlet temperature is 50°C, the atomization pressure is 0.4MPa, and the peristaltic pump speed is 5mL / min. The coating liquid prescription is: 1gHPMC, 20mL ethanol, 1mL Tween-80, 10mL pure water.

[0038] The morphological investigation, determination of drug loading, and encapsulation efficiency of the obtained odorless granules were carried out, wherein the morphological investigation was to observe the shape o...

Embodiment 2

[0040] Weigh each raw material with the following mass percentage (take the total amount as 100g as an example):

[0041]

[0042] Grind and sieve tiamulin fumarate, binders and fillers, mix them evenly, then pour into a boiling granulator and spray pure water into granules, then dry the plain granules; spray the coating solution, and After drying, take out and pass through a 30-60 mesh sieve; finally obtain the finished product of tiamulin fumarate granules.

[0043] Conditions for boiling granulation: the pure water used is 20%, the fan frequency is 25Hz, the air inlet temperature is 40°C, the atomization pressure is 1.2MPa, and the peristaltic pump speed is 255mL / min. The coating liquid prescription is: 2gHPMC, 20mL ethanol, 0.2gPEG6000, 10mL pure water.

[0044] According to the method described in Example 1, the morphology of the obtained odorless granules was investigated, and the drug loading and encapsulation efficiency were measured. The specific results are shown...

Embodiment 3

[0046] Weigh each raw material with the following mass percentage (take the total amount as 100g as an example):

[0047]

[0048]

[0049] Grind and sieve tiamulin fumarate, binder and filler respectively and mix them evenly, pour into the boiling granulator and spray into the aqueous solution of PVP (5g) to granulate, then dry the plain granules; spray coating After drying, take it out and pass through a 30-60 mesh sieve; finally obtain the finished product of tiamulin fumarate granules.

[0050] Conditions for boiling granulation: the pure water used is 40%, the fan frequency is 30Hz, the air inlet temperature is 30°C, the atomization pressure is 0.8MPa, and the peristaltic pump speed is 155mL / min. The coating liquid prescription is: 2gHPMC, 30mL ethanol, 0.2g PEG6000, 1mL Tween-80, 0.1g talcum powder, 10mL pure water.

[0051] According to the method described in Example 1, the morphological investigation, the determination of drug loading, and the determination of ...

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Abstract

The invention relates to a tiamulin fumarate granule, which is characterized in that it comprises the following components in mass percentage: 5-80% tiamulin fumarate; 5-10% binder; 5-88% filler; coating Agent 2 to 5%. By adopting the tiamulin fumarate granule and its preparation method of the present invention, the drug content can be as high as 80%. Because it adopts the boiling granulation method, it avoids that the soft material is too sticky when the drug content is high in the extrusion granulation method. , Difficult to squeeze out the problem. The prepared granules cover the irritating smell of tiamulin fumarate, can increase the feeding rate of animals, and are of great practical value. The preparation process of the invention is simple, the raw materials are cheap and easy to obtain, and are suitable for large-scale industrial production, so it has broad application potential. Application prospect.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to veterinary drugs, in particular to tiamulin fumarate granules and a preparation method thereof. Background technique [0002] Tiamulin fumarate is a semi-synthetic diterpene antibiotic for livestock and poultry. It is a semi-synthetic diterpene-based antibiotic for livestock and poultry. It was first proposed by Kavangh in Australia and extensively studied in the 1960s. It has special effects on a variety of Gram-positive bacteria and mycoplasma. It is mainly used for chicken chronic respiratory diseases, swine mycoplasma pneumonia and Haemophilus pleuropneumonia. It is one of the top ten veterinary products in the world. One of the antibiotics. [0003] Tiamulin (tiamulin, thiamut in, dynamut ilin) ​​is also known as tiamulin, tiamulin, tiamulin, Zhiyuanjing, tiamulin, and tiamulin fumarate is mostly used in practice. Tiamulin is an animal-specific antibiotic. Its antibacter...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K31/22A61K47/26A61K47/38A61K47/04A61K47/10A61P31/04A61K47/32A61K47/36
Inventor 陈倩何林华秦佳琪
Owner SHANGHAI TONGREN PHARM CO LTD
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