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New application of rapamycin for inhibiting plant early blight

A technology of rapamycin and early blight bacteria, which is applied in the directions of plant growth regulators, preservation of human or animal bodies, botanical equipment and methods, etc., can solve problems such as no relevant reports on prevention and control, and achieve good market prospects. , reduced use, the effect of delaying the development of pest resistance

Inactive Publication Date: 2018-06-05
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The earliest research on rapamycin was mainly as a low-toxic antifungal drug, especially against Candida albicans, and it is currently widely used in clinical medicine to prevent rejection of organ transplantation and to treat autoimmune diseases. Inhibitor, the use of this compound to carry out the prevention and treatment of plant early blight has not yet seen relevant reports

Method used

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  • New application of rapamycin for inhibiting plant early blight
  • New application of rapamycin for inhibiting plant early blight
  • New application of rapamycin for inhibiting plant early blight

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1. handle early blight bacteria separately with armor frost hymexazol

[0033] Set the concentration gradient of metalaxe and hymexazol to 0.05ml / L, 0.5ml / L and 1ml / L, respectively prepare PDA medium containing these three different concentrations of metalaxe and hymexazol, and set 3 times for each treatment. repetitions. It can be found by observing the growth of fungi after 12 days of cultivation (such as figure 1 , 2 As shown), with the increase of the concentration of metalazam·hymexazol, the inhibition of fungal growth was more and more obvious. The drug concentration of IC50 is 0.5ml / L.

Embodiment 2

[0034] Embodiment 2. treat early blight bacteria separately with Rapamycin

[0035] Set the concentration gradient of Rapamycin as 1nmol / L, 10nmol / L and 50nmol / L. The PDA medium containing these 3 different concentrations of Rapamycin were prepared respectively, and each treatment was repeated 3 times. It can be found by observing the growth of fungi after 12 days of cultivation (such as image 3 , 4 shown), with the increase of Rapamycin concentration, the inhibition of fungal growth became more and more obvious. The drug concentration of its IC50 is about 50nmol / L.

Embodiment 3

[0036]Embodiment 3. treat early blight bacterium with rapamycin+armazam·hymexazol combination

[0037] The concentrations of rapamycin were: 1nmol / L, 10nmol / L, 50nmol / L; The concentration of the above-mentioned rapamycin and metalazam·hymexazol were combined in pairs to treat the early blight bacteria, a total of 6 combinations. The PDA medium containing rapamycin + metalaxe·hymexazol of these 6 different concentration combinations were prepared respectively, and each treatment was repeated 3 times. It can be found by observing the growth of fungi after 12 days of cultivation (such as Figure 5 , 6 As shown), with the increase of the concentration of rapamycin + metalax · hymexazol combination, the inhibition of fungal growth is more and more obvious. The drug concentration of IC50 is rapamycin: 50nmol / L+nailaxe·hymexazol: 0.05ml / L. When rapamycin is used in combination with the pesticides Naxa-Hymexazol, the IC50 is reached, and the concentration of the pesticide Naxa-Hym...

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Abstract

The invention discloses application of sirolimus in inhibition of plant alternaria solani and further discloses a fungicide. The fungicide contains rapamycin or a mixture of the rapamycin and a chemical fungicide. A TOR protein inhibitor rapamycin used in clinical medicine is used for prevention and control research of plant early blight for the first time, it is found through the research that the rapamycin and the mixture of the rapamycin and the chemical fungicide can effectively inhibit the plant alternaria solani, a chemical rapamycin pesticide can play a synergistic effect to inhibit the plant alternaria solani, a very significative base is provided for research of a novel drug for preventing and controlling the early blight, the novel fungicide is wide in application prospect and market prospect, a new choice is provided for early blight prevention and control, the using amount of the chemical pesticide can be remarkably decreased, and the fungicide has the great significance on reduction of pesticide usage amount and delay of the resistance of insect pests and also has the great application value on maintenance of ecosystem balance and sustainable development.

Description

technical field [0001] The invention relates to a new application of rapamycin, in particular to a new application of rapamycin for inhibiting plant early blight bacteria. Background technique [0002] Early blight, also known as "ring spot disease" or "summer blight", is a fungal disease that can occur at the seedling stage and the adult plant stage. When the disease occurs at the seedling stage, dark brown lesions develop on the base of the stem of the seedlings, slightly sunken, and there are rings. pattern. Adult stage disease generally develops from the lower leaves to the upper part. The initial leaves are water-soaked dark green lesions, which expand to round or irregular ring spots with light green or yellow halos on the edges. The central part has concentric ring patterns, and when it is wet, a black mold layer develops on the diseased part. The main symptom is that there are (concentric) ring patterns on the diseased part. Early blight can infect a variety of pl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/90A01N43/80A01N37/46A01P3/00
CPCA01N37/46A01N43/80A01N43/90A01N2300/00
Inventor 于力华任茂智郑先喆张蜀敏尹欢
Owner CHONGQING UNIV
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