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Traditional Chinese medicine for treating liver and gall wind-heat type primary trigeminal neuralgia and preparation method thereof

A technology for trigeminal neuralgia and wind-heat type, which is applied in medical formulas, nervous system diseases, medical preparations containing active ingredients, etc. It can solve problems such as unclear etiology and pathogenesis, inability to cure TN, and no treatment methods. Achieve good therapeutic effect, non-toxic side effects and adverse reactions, and highly targeted effects

Inactive Publication Date: 2016-09-07
管清华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many options for the treatment of TN, due to its unclear etiology and pathogenesis, there are many hypotheses for a long time, and there is no specific treatment method in clinical practice. Although carbamazepine is the first-line treatment for TN at this stage Drugs, but they cannot cure TN, and clinically, patients often have to choose other drugs because of their tolerance or other adverse reactions such as allergies

Method used

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  • Traditional Chinese medicine for treating liver and gall wind-heat type primary trigeminal neuralgia and preparation method thereof

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preparation example Construction

[0034] The present invention also provides the preparation method of above-mentioned Chinese medicine, and the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

[0035] Step 1: Mix the raw materials of the traditional Chinese medicine preparation in proportion, add ethanol with an alcohol concentration of 85-95% that is 4-6 times the mass of the mixture, heat and reflux for 1-3 hours, extract, and filter to obtain the first extraction liquid, the dregs obtained by filtering are added with ethanol with an alcohol concentration of 85-95% relative to the mass of dregs, which is 1-3 times the mass of the dregs, heated and refluxed for 1-2 hours, extracted, filtered to obtain the second extract, and the first extract Combine with the second extract, concentrate under reduced pressure to remove the ethanol solvent, and dry to obtain a dry paste;

[0036]The second step: put the dry paste obtained in the first step into a ...

Embodiment 1

[0042] Embodiment 1: tablet

[0043] Take 440g of Wenghua, 90g of Saxifrage, 580g of Manjianghong, 410g of Shrimp Grass, 70g of Rock Seven, 130g of Dasha Ye, 110g of Woer Seven, 280g of Wild Amaranth, 420g of Hairy Gerbera, 140g of Pen Tube Grass and 260g of White Cauliflower;

[0044] Prepare as follows:

[0045] The first step: mix the raw materials of the traditional Chinese medicine preparation in proportion, add ethanol with an alcohol concentration of 95% that is 5 times the mass of the mixture, heat and reflux for 3 hours, extract, filter to obtain the first extract, and filter the obtained drug Then add ethanol with an alcohol concentration of 95% that is 3 times the mass of the dregs, heat and reflux for 2 hours, extract, filter to obtain the second extract, combine the first extract and the second extract, and concentrate under reduced pressure to remove ethanol solvent, dried to obtain a dry paste;

[0046] The second step: place the dry paste obtained in the firs...

Embodiment 2

[0048] Embodiment 2: Granules

[0049] Take 420g of Shuiwenghua, 80g of Saxifrage, 550g of Manjianghong, 430g of Shrimp Raft, 100g of Rock Seven, 110g of Dashaye, 140g of Woerqi, 260g of Wild Amaranth, 430g of Hairy Gerbera, 120g of Pen Tube Grass and 290g of White Cauliflower;

[0050] Prepare as follows:

[0051] The first step: mix the raw medicinal materials according to the stated ratio, add ethanol with an alcohol concentration 6 times that of the mixture and 80% ethanol, heat to boiling and reflux for 2 hours, filter, use the reflux liquid as the solvent, and use the filter residue as the solute, Use the percolation method to percolate slowly at a rate of 2ml per minute, collect the percolation liquid, and then concentrate it under reduced pressure at a vacuum of 0.05Mpa to a paste with a relative density of 1.05 at 80°C, spray dry, and spray the dryer. The air temperature is 185°C and the outlet air temperature is 85°C, and then crushed into powder to make dry cream p...

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Abstract

The invention provides a traditional Chinese medicine for treating liver and gall wind-heat type primary trigeminal neuralgia and a preparation method thereof. The traditional Chinese medicine comprises the following raw medicinal materials: water banyan, carnose goldsaxifrage herb, azoila imbricate, capitatestigma willowweed herb, rheum forrestii, pavetta arenosa, Chinese umbrellaleaf rhizome and root, amaranthus viridis, pilose gerbera herb, ramose scouring rush herb and cauliflower. The traditional Chinese medicine disclosed by the invention has the beneficial effects that the traditional Chinese medicine has high pertinence on liver and gall wind-heat type primary trigeminal neuralgia, is good in treatment effects and does not have any toxic or side effect or untoward effects.

Description

technical field [0001] The invention relates to a medical preparation containing components derived from plants, animals or minerals, in particular to a traditional Chinese medicine for treating hepatobiliary wind-heat type primary trigeminal neuralgia and a preparation method thereof. Background technique [0002] Primary trigeminal neuralgia (TN) is a clinically common and frequently-occurring disease, characterized by recurrent paroxysmal pain in the distribution area of ​​the trigeminal nerve, the pain is often short but severe, and lasts for several seconds to several minutes , asymptomatic in the intermittent period, which seriously affects the life and work of the patient. The attack can be spontaneous, but there may be a "trigger point", which can be induced by slight tactile stimulation in the face and mouth. The disease can be fixed in the trigeminal nerve for a long time. A certain branch of the disease, the second and third branches are the most common, and sever...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61P25/02
CPCA61K36/61A61K9/1652A61K9/2059A61K36/11A61K36/185A61K36/21A61K36/28A61K36/29A61K36/74A61K2236/333
Inventor 管清华王润英李洪娜
Owner 管清华
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