Azacyclic transition metal zinc complex containing multiple coordination sites, and preparation method and application of azacyclic transition metal zinc complex

A transition metal and zinc complex technology, applied in the field of medicine, can solve the problems of unsatisfactory hypoglycemic effect of asymmetric nitrogen heterocyclic compounds, human toxicity, etc., and achieves easy technological promotion, low production cost, good social and environmental protection. economic effect

Inactive Publication Date: 2016-09-28
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, large doses of transition metals can cause toxic effects on the human body, and the use of asymmetric nitrogen heterocyclic compounds alone is not ideal for hypoglycemic effects.

Method used

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  • Azacyclic transition metal zinc complex containing multiple coordination sites, and preparation method and application of azacyclic transition metal zinc complex
  • Azacyclic transition metal zinc complex containing multiple coordination sites, and preparation method and application of azacyclic transition metal zinc complex
  • Azacyclic transition metal zinc complex containing multiple coordination sites, and preparation method and application of azacyclic transition metal zinc complex

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The preparation method of ligand 1-(benzotriazole-1-methyl)-1-(2-ethylimidazole) of the present invention comprises the following steps:

[0037] (1) Mix 11.9g of benzotriazole, 30ml of water and 30ml of formaldehyde, heat and stir to dissolve the solid, heat in a water bath at 80°C for 1h, cool, filter to obtain a white needle-like product, and recrystallize with ethyl acetate to obtain White crystals, that is, hydroxymethylbenzotriazole;

[0038] (2) Add 7.4g of hydroxymethylbenzotriazole into the one-mouth bottle, add 25ml of SOCl dropwise 2 After the dropwise addition, mix and stir for 30min, reflux at 80°C for 3h; use a rotary evaporator to evaporate excess SOCl 2 , to obtain white crystals, that is, chloromethylbenzotriazole;

[0039] (3) Take 40mmol of 2-ethylimidazole, dissolve it in 20ml of dimethyl sulfoxide (DMSO), add 80mmol of crushed NaOH, heat to 60°C, then add 40mmol of chloromethylbenzotriazole, and put it in a water bath at 60°C Heated for 1 hour, c...

Embodiment 2

[0043] A preparation method of a nitrogen-heterocyclic transition metal zinc complex containing multiple coordination sites, comprising the following steps:

[0044] (1) Accurately weigh zinc acetate [Zn(Ac) 2 ] 0.02mmol, be dissolved in 4ml methyl alcohol, obtain zinc salt solution;

[0045] (2) Accurately weigh 0.02mmol of the ligand 1-(benzotriazole-1-methyl)-1-(2-ethylimidazole), dissolve it in 4ml of methanol, and obtain a ligand solution;

[0046] (3) Accurately weigh 0.02mmol KSCN, dissolve it in 1ml water to obtain a KSCN solution; and add the KSCN solution to the zinc salt solution to obtain a mixed solution;

[0047] (4) Add the ligand solution into the mixed solution, mix well, filter, add methanol to the filtrate to 14ml, and let it stand at room temperature until colorless rectangular crystals are precipitated.

[0048] The experimental conditions and results of the X-ray single crystal diffraction structure of the complex of the present invention are as follows...

Embodiment 3

[0052] A preparation method of a nitrogen-heterocyclic transition metal zinc complex containing multiple coordination sites, comprising the following steps:

[0053] (1) Accurately weigh ZnSO 4 0.03mmol, dissolved in 5ml water to obtain zinc salt solution;

[0054] (2) Accurately weigh 0.03 mmol of ligand 1-(benzotriazole-1-methyl)-1-(2-ethylimidazole), dissolve it in 5ml of methanol, and obtain a ligand solution;

[0055] (3) Accurately weigh 0.03mmol KSCN and dissolve it in 2ml water to obtain a KSCN solution; and add the KSCN solution to the zinc salt solution to obtain a mixed solution;

[0056] (4) Add the ligand solution into the mixed solution, mix well, filter, add ethanol to the filtrate to 16ml, and let it stand at room temperature until colorless rectangular crystals are precipitated.

[0057] The single crystal structure of the as-prepared azacyclic transition metal zinc complex is shown in figure 1 , 2 , the complex belongs to the triclinic crystal system, th...

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Abstract

The invention discloses an azacyclic transition metal zinc complex containing multiple coordination sites, and a preparation method and application of the azacyclic transition metal zinc complex. The azacyclic transition metal zinc complex is a 1-(benzotriazole-1-methyl)-1-(2-ethyl imidazole) zinc complex, and has a molecular formula of [Zn (SCN) 2(C12H13N5)2]. The azacyclic transition metal zinc complex, namely, the 1-(benzotriazole-1-methyl)-1-(2-ethyl imidazole) zinc complex provided by the invention has a higher inhibiting effect for alpha-amylase, and the inhibiting effect of the 1-(benzotriazole-1-methyl)-1-(2-ethyl imidazole) zinc complex is much higher than that of singly-used 1-(benzotriazole-1-methyl)-1-(2-ethyl imidazole) or transition metal salt for the alpha-amylase and is higher than that of commonly-used hypoglycemic agent acarbose for the alpha-amylase. Therefore, the azacyclic transition metal zinc complex is proved to have a good hypoglycemic effect so as to be effectively used for preparing medicines for treating diabetes mellitus, and is an innovation in the aspect of medicines for treating the diabetes mellitus.

Description

technical field [0001] The invention relates to a nitrogen-heterocyclic transition metal zinc complex containing multiple coordination points, a preparation method and application, and belongs to the technical field of medicine. Background technique [0002] Diabetes is a metabolic disease characterized by high blood sugar. The long-term high blood sugar in diabetes can easily lead to chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves. At present, the global prevalence of diabetes is in a period of rapid rise, and my country has become the country with the largest number of diabetic patients in the world. According to relevant reports, among the numerous diabetic patients, type 2 diabetes patients account for 90%-95%. It has become one of the major diseases threatening human health. [0003] At present, the methods adopted for the treatment of type 2 diabetes mainly include: oral hypoglycemic drugs, insulin in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F3/06A61P3/10
CPCC07F3/003C07F3/06
Inventor 王霞张超曾岱程迪宋宁杨怀霞
Owner HENAN UNIV OF CHINESE MEDICINE
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