Mild-hypothcrmia-inducing medicinal composite preparation and application thereof

A technology of drugs and preparations, applied in the field of drug combination preparations for inducing mild hypothermia, which can solve problems such as excessive physiological and psychological stress responses, affect the effect of hypothermia treatment, and hinder the target cooling temperature, so as to achieve small body temperature fluctuations and shorten the induction time , Excellent therapeutic effect

Inactive Publication Date: 2016-10-12
福州冬眠医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The response of these thermoreceptors hinders the reaching of the target cooling temperature, and at the same time causes excessive phy

Method used

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  • Mild-hypothcrmia-inducing medicinal composite preparation and application thereof
  • Mild-hypothcrmia-inducing medicinal composite preparation and application thereof
  • Mild-hypothcrmia-inducing medicinal composite preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 1. The composition and dosage of the drug combination preparation

[0038] 1. Anesthetics: pentobarbital sodium (50mg / kg) or chloral hydrate (300mg / kg)

[0039] 2. Thermoregulators: chlorpromazine (5mg / kg), bromocriptine (20mg / kg) or adenosine 5-phosphate (10mg / kg)

[0040] 3. Sedatives: promethazine (5mg / kg) or acepromazine (20mg / kg)

[0041] 2. Methods of Inducing Regulatory Mild Hypothermia

[0042] 1.1 Experimental materials and instruments

[0043] Healthy adult male SD rats, weighing 250±50g, were provided by the Experimental Animal Center of Fujian Medical University.

[0044] Cooling blanket for rapid cooling and low temperature control box for maintaining sub-low temperature.

[0045] 1.2 Experimental grouping

[0046] Eighteen normal rats were randomly divided into 3 groups, 6 in each group. Normal saline control group: normal temperature group, positive control group: pure physical cooling group, experimental group: sub-low temperature hibernation group...

Embodiment 2

[0075] Example 2 Application of regulatory hypothermic drug combination preparation in drug poisoning

[0076] 1 material description

[0077] Healthy adult male SD rats, weighing 250±50g, were provided by the Experimental Animal Center of Fujian Medical University.

[0078] 2 Experimental methods

[0079] 2.1 Experimental grouping

[0080] Twelve normal rats were randomly divided into 2 groups, 6 rats in each group. Control group: isoniazid poisoning group, experimental group: isoniazid hypothermic hibernation group.

[0081] 2.2 Experimental processing

[0082] Isoniazid poisoning was carried out, and rats were injected intraperitoneally with isoniazid 400mg / kg. For the isoniazid poisoning group, the occurrence and duration of each convulsion, as well as the time of death, were observed and recorded after administration. For the isoniazid sub-hypothermic hibernation group, when the rats convulsion first appeared, the regulatory hypothermia combination preparation was i...

Embodiment 3

[0088] Example 3 Application of regulatory hypothermic drug combination preparation in pesticide poisoning

[0089] 1 Experimental materials

[0090] Healthy adult male SD rats, 2-3 months old, weighing 250±50g, were provided by the Experimental Animal Center of Fujian Medical University.

[0091] 2 Experimental methods

[0092] 2.1 Experimental grouping

[0093] Twelve normal rats were randomly divided into 2 groups, 6 rats in each group. Control group: Dimehypo poisoning group, experimental group: Dimehypo sub-low temperature hibernation group.

[0094] 2.2 Experimental processing

[0095] Dimehypo poisoning was carried out, rats were orally fed with 1800 mg / kg of dimehypo, and the symptoms of the rats were observed after administration. For the dimehypo poisoning group, only dimehypo was given, and then the time and phenomenon of poisoning symptoms were observed and recorded, such as increased activity, general tremor, involuntary acute jumping or clonic convulsions, a...

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Abstract

The invention relates to a drug combination preparation for inducing mild hypothermia and its application. The drug combination preparation for inducing mild hypothermia includes anesthetics, thermoregulators and sedatives. The dosage of the anesthetics is 10-500 mg/kg. The dosage of the thermoregulator is 5-50 mg/kg, and the dosage of the sedative is 5-50 mg/kg. The pharmaceutical combination preparation of the present invention can reduce the stress response and prevent skin frostbite when inducing regulatory mild hypothermia, quickly reach the target temperature, significantly reduce the metabolism of the drug recipient, have small fluctuations in body temperature, and control blood sugar within the normal range. First aid for chemical or drug poisoning, hypoxia, trauma, ischemia, endotoxemia, skin burns, hypoglycemia, etc.

Description

technical field [0001] The invention relates to a drug combination preparation for inducing mild hypothermia and its application, belonging to the field of medicine. Background technique [0002] The international medical community usually divides hypothermia into 4 levels: 32-35°C is mild hypothermia; 28-32°C is moderate hypothermia; 17-27°C is profound hypothermia; 16°C The following is ultra-profound hypothermia. Sub-low temperature mainly refers to mild and moderate low temperature (28 ℃ ~ 35 ℃). Clinically, mild hypothermia therapy is also called hibernation therapy or artificial hibernation. Mild hypothermia hibernation therapy has been clinically used for forty to fifty years for organ protection from a variety of pathophysiological injuries, including ischemic injuries, such as cardiac arrest, blood loss, hypoglycemia, hypergravity, and relief from many drug and environmental toxicity. [0003] At present, clinical therapeutic mild hypothermia generally includes ...

Claims

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Application Information

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IPC IPC(8): A61K31/515A61K31/11A61K31/5415A61K31/48A61K31/7076A61K45/06A61P29/00A61P23/00A61P25/20
CPCA61K31/515A61K31/11A61K31/48A61K31/5415A61K31/7076A61K45/06
Inventor 周阳璇林金香
Owner 福州冬眠医疗科技有限公司
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