Antithrombotic medicine

An antithrombotic and drug technology, applied in the field of antithrombotic pharmaceutical compositions, can solve the problems of unsatisfactory treatment effect of cannabidiol, and achieve the effects of inhibiting platelet aggregation in rats, excellent effect and reducing viscosity of whole blood

Inactive Publication Date: 2016-10-12
云南瑞酚生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are also reports on antithrombotic diseases, but the therapeutic effect of cannabidiol (CBD) alone is not satisfactory

Method used

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  • Antithrombotic medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The flowers, leaves, hemp bran and hemp seeds of "Yunma No. 1", an industrial hemp variety grown in Yunnan, are used as raw materials. Take mature industrial hemp hemp seeds, dry, remove impurities, and crush them for later use; use ethanol to extract the crushed hemp seeds (at 60-85°C, heat and extract twice, each time for 1-3 hours ), the ethanol concentration is 95% to 100% (V / V), and the ratio of solid to liquid is 1:5 to 1:20; the extract is filtered out and concentrated under reduced pressure to obtain the industrial hemp hemp seed extract.

[0031] Take the mixture of industrial hemp flowers, leaves and hemp bran in a mass ratio of 1:3:2, dry, remove impurities, and pulverize to 10-60 mesh; supercritical carbon dioxide extraction: put the above-mentioned pulverized industrial hemp raw materials into supercritical In the carbon dioxide extraction device, the extraction temperature is controlled at 40-50°C, the extraction time is 30-90min, the extraction pressure i...

Embodiment 2

[0034] Repeat Example 1, with the following differences: when extracting industrial hemp hemp seeds with ethanol, extract at room temperature, and extract 2 times for each batch of materials, each for 7 to 10 days. A 1:1:1 mass ratio mixture of flowers, leaves, and hemp bran of industrial hemp is used as a raw material for extracting hemp cannabinoids.

[0035]Get 0.3 part of industrial hemp hemp seed extract, 99.7 parts of industrial hemp cannabinoid, mix well, obtain medicine A of the present invention.

Embodiment 3

[0037] Repeat Example 1, the following difference is arranged: when extracting industrial hemp hemp seed with ethanol, adopt ultrasonic assisted extraction, ultrasonic frequency 30~60kHz, power 100~1000W, extraction time 30~60min, leaching temperature 25~ 50°C. A 3:2:1 mass ratio mixture of flowers, leaves, and hemp bran of industrial hemp is used as the raw material for extracting hemp cannabinoids.

[0038] Get 99.7 parts of industrial hemp hemp seed extract, 0.3 part of industrial hemp cannabinoid, mix well, obtain medicine C of the present invention.

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PUM

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Abstract

The invention discloses an antithrombotic medicine. The antithrombotic medicine is prepared by evenly mixing, by weight, 0.3-99.7 parts of fructus cannabis extract and 99.7-0.3 part of industrial cannabinoid. Experiments show that the medicine has a remarkable antithrombotic effect, can remarkably suppress formation of thrombus in the bodies of rats, has a remarkable suppressing effect on platelet aggregation of rats, can remarkably delay the blood coagulation time of rats, can reduce the whole blood viscosity, plasma viscosity and packed cell volume of rats, has a better acting effect than cannabidiol, and has good application prospects.

Description

technical field [0001] The invention belongs to the field of medicines for treating thrombosis, and in particular relates to an antithrombotic pharmaceutical composition prepared from industrial hemp as a main raw material. Background technique [0002] The cultivation of hemp has a long history. In ancient times, hemp was mainly used to make and process ropes, fishing nets, clothing and paper-making raw materials, as well as oil and food. With the development and progress of society, people found that a toxic ingredient (tetrahydrocannabinol) in marijuana can make people addicted to hallucinations. Many countries in Europe and the United States have banned the cultivation of marijuana for a long time. Due to the high economic value of cannabis, by the 1980s, some European countries had researched and bred low-toxic cannabis varieties and promoted their cultivation. In 1990, the European Community took the lead in urgently revising the agricultural policy, abolished the pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/60A61P7/02
CPCA61K36/60A61K2236/333A61K2236/37A61K2300/00
Inventor 陈天睿胡瀞月
Owner 云南瑞酚生物科技有限公司
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