Application of total flavones of oldenlandia diffusa willd in preparing drugs for treating meningeal microcirculation disturbance and cerebral ischemia by serving as only active site

Abstract

The invention relates to application of total flavones of oldenlandia diffusa willd in preparing drugs for treating meningeal microcirculation disturbance and cerebral ischemia by serving as the only active site. The total flavones of oldenlandia diffusa willd are obtained through the steps that oldenlandia diffusa willd is smashed into crude powder, reflux extraction is conducted with petroleum ether, and degreasing is conducted; residues with petroleum ether volatilized completely are soaked with ethyl alcohol, reflux extraction is conducted twice, filtrate for the two times are combined, ethyl alcohol is subjected to vacuum recycling till no alcohol taste exists, distilled water is added, the treated filtrated is dispersed into a sample solution, AB-8 type macroporous adsorption resin is applied to the sample solution, elution is conducted with the distilled water, and water liquid is discarded; elution is conducted with 10% ethyl alcohol and then with 80% ethyl alcohol, 80% ethyl alcohol eluant is collected, ethyl alcohol is subjected to vacuum recycling till no alcohol taste exists, freeze drying and smashing are conducted, and the total flavones of oldenlandia diffusa willd are obtained. According to the application of the total flavones of oldenlandia diffusa willd in preparing the drugs for treating the meningeal microcirculation disturbance and cerebral ischemia by serving as the only active site, the effect of improving the meningeal microcirculation disturbance and cerebral ischemia is achieved, the total flavones of oldenlandia diffusa willd serving as the only active site are effectively used for preparing the drugs for treating the meningeal microcirculation disturbance and cerebral ischemia, and innovation on treating the meningeal microcirculation disturbance and cerebral ischemia is achieved.

Description

technical field [0001] The invention relates to medicine, especially the application of the total flavonoids of Hedyotis diffusa as the only active part in the preparation of medicines for treating meningeal microcirculation disorders and cerebral ischemia. Background technique [0002] Microcirculation directly supplies cells with blood, oxygen, energy and related nutrients, and at the same time discharges harmful metabolites. It is the internal environment of the human body and the most basic guarantee of life. Any organ and any part of the human body (including the heart) must have a normal and healthy microcirculation, otherwise there will be pathological changes in the corresponding organs. [0003] Under normal circumstances, the microcirculatory blood flow adapts to the metabolic level of human tissues and organs, so that the physiological functions of various internal organs of the human body can be carried out normally. If the microcirculation is not smooth, it is ...

AI Technical Summary

Problems solved by technology

The onset has no aura, and there are transient signs of nervous system positioning. Generally, there is no disturbance of consciousness. It lasts for 5 to 20 minutes. It can recur, but it usually recovers completely within 24 hours without sequelae, but it has different degrees of adverse effects on health.

Although there are multiple drugs for the treatment of meningeal microcirculation and cerebral ischemia, their use and curative effect are not satisfactory due to various reasons. Therefore, it is imperative to research and develop new drugs

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