Compound taxus chinensis boil-free granules as well as preparation method and application thereof

A technology of compound yew and decoction-free granules, which is applied in the field of compound yew decoction-free granules and its preparation, can solve the problems of complex process, destruction of active ingredients, and low dissolution rate, and achieve simple preparation, high bioavailability, and promotion The effect of sebum metabolism

Inactive Publication Date: 2016-10-12
无锡紫杉药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In Chinese traditional medicine, the main clinical application of traditional Chinese medicine is decoction, making full use of the synergistic effect of various water-soluble functional components in order to achieve better therapeutic effects, but usually there are complex processes, and the dissolution rate is not high, effective Disadvantages such as the composition being destroyed

Method used

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  • Compound taxus chinensis boil-free granules as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] A preparation method of compound yew decoction-free granules, comprising the following steps:

[0048] (1) Take the southern yew (twigs, leaves), raw barley, salvia miltiorrhiza, Phellodendron chinensis, purple peony root, Patina, Folium Folium, dandelion, Anemarrhena anemarrhena, scutellaria baicalensis, honeysuckle, Alisma, centipede, dried, smash. Pass through a 80-mesh sieve, and the under-sieve is ready for use.

[0049] (2) Take 10kg of the undersieve, put it into an ultrasonic wall breaking extraction tank, add 15 times of water, fully stir and soak at 50°C for 1 hour.

[0050] (3) Using high-power ultrasonic generator, power 15-30kW, frequency 20-25kHZ, sound intensity 2W / cm 2 , sonicated for 30 minutes.

[0051] (4) Transfer the feed solution after ultrasonic wall breaking to a stirring extraction tank, add 0.3% (g / g) neutral protease, adjust the pH to 6.8, and perform enzymatic hydrolysis for 90 minutes. Hydrolyzes free proteins in glycoproteins and glycan...

Embodiment 2

[0057] A preparation method of compound yew decoction-free granules, comprising the following steps:

[0058] (1) Take the southern yew (twigs, leaves), raw barley, salvia miltiorrhiza, Phellodendron chinensis, purple peony root, Patina, Folium Folium, dandelion, Anemarrhena anemarrhena, scutellaria baicalensis, honeysuckle, Alisma, centipede, dried, smash. Pass through a 80-mesh sieve, and the under-sieve is ready for use.

[0059] (2) Take 10kg of the undersieve, put it into an ultrasonic wall breaking extraction tank, add 15 times of water, fully stir and soak at 50°C for 1 hour.

[0060] (3) Using high-power ultrasonic generator, power 15-30kW, frequency 20-25kHZ, sound intensity 2W / cm 2 , sonicated for 40 minutes.

[0061] (4) Transfer the feed solution after ultrasonic wall breaking to a stirring extraction tank, add 0.5% (g / g) neutral protease, adjust the pH to 7.0, and perform enzymatic hydrolysis for 90 minutes. Hydrolyzes free proteins in glycoproteins and glycan...

Embodiment 3

[0067] A preparation method of compound yew decoction-free granules, comprising the following steps:

[0068] (1) Take the southern yew (twigs, leaves), raw barley, salvia miltiorrhiza, Phellodendron chinensis, purple peony root, Patina, Folium Folium, dandelion, Anemarrhena anemarrhena, scutellaria baicalensis, honeysuckle, Alisma, centipede, dried, smash. Pass through a 80-mesh sieve, and the under-sieve is ready for use.

[0069] (2) Take 10kg of the undersieve, put it into an ultrasonic wall breaking extraction tank, add 15 times of water, fully stir and soak at 50°C for 1 hour.

[0070] (3) Adopt high-power ultrasonic generator, power 15-30kW, frequency 20-25kHZ, sound intensity 3W / cm 2 , sonicated for 30 minutes.

[0071] (4) Transfer the feed solution after ultrasonic wall breaking to a stirring extraction tank, add 0.8% (g / g) neutral protease, adjust the pH to 6.9, and perform enzymatic hydrolysis for 90 minutes. Hydrolyzes free proteins in glycoproteins and glycan...

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Abstract

The invention provides compound taxus chinensis boil-free granules as well as a preparation method and application thereof. The preparation method takes substances including taxus chinensis, semen coicis, radix salviae miltiorrhizae, cortex phellodendri, purple peony roots, herba patriniae, folium isatidis, taraxaci herba, rhizoma anemarrhenae, radix scutellariae, honeysuckle flowers, rhizoma alismatis and centipedes as raw materials and the compound taxus chinensis boil-free granules can be prepared from the raw materials through the steps of extracting, refining, spraying and drying. The prepared compound taxus chinensis boil-free granules can be used for preparing medicines or cosmetics; a dosage form process is developed, a drug administration manner is direct and the bioavailability is high; when the drug is directly used for an affected part, the healing speed is rapid and the ideal effect of treating comedonal acne can be realized in short time.

Description

technical field [0001] The invention belongs to the field of medicinal plant development, in particular to a compound yew decoction-free granule and its preparation method and application. Background technique [0002] Acne is an acute or chronic inflammation of the pilosebaceous glands, with various lesions such as blackheads, papules, pustules, nodules, abscesses, cysts, and scars, and is prone to occur on the face, chest and back. The common ones are acne vulgaris and acne conglobata. The disease is also known as youth acne, mostly occurs in adolescent men and women, often accompanied by seborrhea. After puberty, most of them heal or alleviate naturally. [0003] The records of acne in traditional Chinese medicine are very early, such as the existing records in "Su Wen Qi Tong Tian Lun". "The Golden Mirror of Medicine Surgical Heart Method" calls this disease "lung wind acne". Break out white powder juice". The traditional Chinese medical science also has this diseas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8994A61K9/16A61K8/98A61K8/97A61P17/10A61P35/00A61P3/10A61P37/04A61P3/06A61P9/12A61P29/00A61P9/10A61Q19/00A61K35/648
CPCA61K36/13A61K8/97A61K8/987A61K9/1605A61K35/648A61K36/185A61K36/195A61K36/288A61K36/315A61K36/355A61K36/537A61K36/539A61K36/65A61K36/704A61K36/71A61K36/756A61K36/855A61K36/884A61K36/8964A61K36/8994A61K2236/19A61K2236/331A61K2236/51A61Q19/00A61K2300/00
Inventor 田连忠汤志伟刘雷
Owner 无锡紫杉药业股份有限公司
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