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3DP (three-dimensional printed) hawthorn leaf flavonoid dispersible tablets and preparation method for same

A 3D printing, hawthorn leaf technology, applied in medical preparations containing active ingredients, pharmaceutical formulations, plant/algae/fungus/moss components, etc. High utilization, fast onset effect

Inactive Publication Date: 2016-11-09
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the formulations of total flavonoids from hawthorn leaves have been in the form of dispersible tablets (name: Yixindone dispersible tablets), but the commercially available Yixindone dispersible tablets are made by tableting process, and the disintegration speed is relatively slow

Method used

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  • 3DP (three-dimensional printed) hawthorn leaf flavonoid dispersible tablets and preparation method for same
  • 3DP (three-dimensional printed) hawthorn leaf flavonoid dispersible tablets and preparation method for same
  • 3DP (three-dimensional printed) hawthorn leaf flavonoid dispersible tablets and preparation method for same

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Experimental program
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preparation example Construction

[0030] A preparation method of 3D printing hawthorn leaf total flavonoids dispersible tablet is characterized in that it comprises the following steps:

[0031] (1) Calculated by weight percentage, the total flavonoids of hawthorn leaves 10-30%, microcrystalline cellulose 55-80%, povidone 10-15%, micropowder silica gel 0.1-0.5%, and flavoring agent 0-0.5% The ratio is mixed evenly, and it is loaded into the powder box of the 3D printing rapid prototyping machine as a powder;

[0032] (2) Put the adhesive into the ink cartridge;

[0033] (3) According to the pre-set parameters, model and import it into the control system of the 3D printing rapid prototyping machine;

[0034] (4) The control system outputs instructions to control the 3D printing rapid prototyping machine to print the dispersible tablets of total flavonoids of hawthorn leaves: the powder spreading device first spreads a layer of medicated powder with a thickness of 0.1mm on the powder bed, and then sprays the ad...

Embodiment 1

[0040] The prescription of the 3D printing hawthorn leaf total flavonoids dispersible tablet of the present embodiment is as follows:

[0041] name

Proportion(%)

Hawthorn Leaf Total Flavonoids

12.8

Microcrystalline Cellulose PH101

77

Povidone K30

10

Micropowder silica gel

0.2

Adhesive

75% ethanol

[0042] The 3D printing parameters of this embodiment are as follows:

[0043]

[0044]

[0045] The preparation method is as follows:

[0046] 1. Mix the total flavonoids of hawthorn leaves, microcrystalline cellulose PH101, povidone K30, and micropowder silica gel evenly in proportion, and put them into the powder box of the LTY-200 three-dimensional printing rapid prototyping machine;

[0047] 2. Put the adhesive into the cartridge;

[0048] 3. According to the pre-set parameters, use CAD and other software to model, and convert it into an stl format file and import it into the LTY software control system ...

Embodiment 2

[0052] The prescription of the 3D printing hawthorn leaf total flavonoids dispersible tablet of the present embodiment is as follows:

[0053] name

Proportion(%)

Hawthorn Leaf Total Flavonoids

20

Microcrystalline Cellulose PH101

69.3

Povidone K30

10

Micropowder silica gel

0.2

Sucralose

0.5

Adhesive

75% ethanol

[0054] The 3D printing parameters of this embodiment are as follows:

[0055]

[0056]

[0057] The preparation method is as follows:

[0058] 1. Mix the total flavonoids of hawthorn leaves, microcrystalline cellulose PH101, povidone K30, micropowder silica gel, and sucralose in proportion, and put them into the powder box of the LTY-200 three-dimensional printing rapid prototyping machine;

[0059] 2. Put the adhesive into the cartridge;

[0060] 3. According to the pre-set parameters, use CAD and other software to model, and convert it into an stl format file and import it into the LT...

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Abstract

The invention discloses 3DP (three-dimensional printed) hawthorn leaf flavonoid dispersible tablets and a preparation method for the same. The dispersible tablets are prepared from the following components in percentage by weight: 10 to 30 percent of hawthorn leaf flavonoids, 55 to 80 percent of microcrystalline cellulose, 10 to 15 percent of povidone, 0.1 to 0.5 percent of aerosil and 0 to 0.5 percent of a flavoring agent. Compared with conventional compressed Yixintong dispersible tablets, the hawthorn leaf flavonoid dispersible tablets printed by a 3DP technology have the characteristics of higher disintegration speed, higher bioavailability, more convenience for administration and the like, are particularly suitable for patients with swallowing difficulties, and can work faster to meet treatment requirements of acute diseases such as angina pectoris and cerebral ischemia. Moreover, compared with the prior art, the 3DP technology has the advantages that dosages suitable for the patients can be customized to realize personalized medication and accurate treatment according to individual differences of the patients and degrees of symptoms, so that tablets taken by the patients are reduced, maximum curative effects of the tablets are achieved, and the toxic or side effects of the tablets are maximally reduced.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a 3D printed hawthorn leaf total flavonoid dispersible tablet and a preparation method thereof. Background technique [0002] Powder-liquid three-dimensional printing (3DP) technology is a rapid prototyping technology developed by the Massachusetts Institute of Technology in the late 1980s. This technology uses liquid to bond multiple layers of powder together to form a three-dimensional structure. Specifically, the technology first lays down a thin layer of powder, and then sprays droplets on selected areas. The interaction between the droplets and the powder causes the materials to bond together at the microscopic level; powder. This is repeated until the printing of the tablet is completed. Compared with the traditional tablet compression technology, the tablet prepared by this technology has a porous structure, "even a small sip of water can make the tab...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K36/734A61P9/10A61K127/00
CPCA61K9/0056A61K9/2054A61K9/2095A61K36/734
Inventor 刘强曹思玮陈活记乡世健洪军辉阮世发朱红霞翁立冬
Owner SOUTHERN MEDICAL UNIVERSITY
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