3DP (three-dimensional printed) hawthorn leaf flavonoid dispersible tablets and preparation method for same
A 3D printing, hawthorn leaf technology, applied in medical preparations containing active ingredients, pharmaceutical formulations, plant/algae/fungus/moss components, etc. High utilization, fast onset effect
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[0030] A preparation method of 3D printing hawthorn leaf total flavonoids dispersible tablet is characterized in that it comprises the following steps:
[0031] (1) Calculated by weight percentage, the total flavonoids of hawthorn leaves 10-30%, microcrystalline cellulose 55-80%, povidone 10-15%, micropowder silica gel 0.1-0.5%, and flavoring agent 0-0.5% The ratio is mixed evenly, and it is loaded into the powder box of the 3D printing rapid prototyping machine as a powder;
[0032] (2) Put the adhesive into the ink cartridge;
[0033] (3) According to the pre-set parameters, model and import it into the control system of the 3D printing rapid prototyping machine;
[0034] (4) The control system outputs instructions to control the 3D printing rapid prototyping machine to print the dispersible tablets of total flavonoids of hawthorn leaves: the powder spreading device first spreads a layer of medicated powder with a thickness of 0.1mm on the powder bed, and then sprays the ad...
Embodiment 1
[0040] The prescription of the 3D printing hawthorn leaf total flavonoids dispersible tablet of the present embodiment is as follows:
[0041] name
Proportion(%)
Hawthorn Leaf Total Flavonoids
12.8
Microcrystalline Cellulose PH101
77
Povidone K30
10
Micropowder silica gel
0.2
75% ethanol
[0042] The 3D printing parameters of this embodiment are as follows:
[0043]
[0044]
[0045] The preparation method is as follows:
[0046] 1. Mix the total flavonoids of hawthorn leaves, microcrystalline cellulose PH101, povidone K30, and micropowder silica gel evenly in proportion, and put them into the powder box of the LTY-200 three-dimensional printing rapid prototyping machine;
[0047] 2. Put the adhesive into the cartridge;
[0048] 3. According to the pre-set parameters, use CAD and other software to model, and convert it into an stl format file and import it into the LTY software control system ...
Embodiment 2
[0052] The prescription of the 3D printing hawthorn leaf total flavonoids dispersible tablet of the present embodiment is as follows:
[0053] name
Proportion(%)
Hawthorn Leaf Total Flavonoids
20
Microcrystalline Cellulose PH101
69.3
Povidone K30
10
Micropowder silica gel
0.2
0.5
75% ethanol
[0054] The 3D printing parameters of this embodiment are as follows:
[0055]
[0056]
[0057] The preparation method is as follows:
[0058] 1. Mix the total flavonoids of hawthorn leaves, microcrystalline cellulose PH101, povidone K30, micropowder silica gel, and sucralose in proportion, and put them into the powder box of the LTY-200 three-dimensional printing rapid prototyping machine;
[0059] 2. Put the adhesive into the cartridge;
[0060] 3. According to the pre-set parameters, use CAD and other software to model, and convert it into an stl format file and import it into the LT...
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