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Starch-based empty capsule containing nonspecific immunity enhancer

A non-specific immunity and starch-based technology, applied in the field of medicine, can solve the problems of poor high-temperature stability, difficult storage, and easy brittleness of capsules, and achieve the goal of improving non-specific immunity, high filling rate, and good stability Effect

Active Publication Date: 2016-11-09
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are reports in the literature that this type of capsule has physical and chemical performance defects such as long disintegration time, easy to become brittle at low temperature, and difficult to store at a temperature above 30°C.
CN105456226A discloses a hydroxypropyl cellulose / hydroxypropyl starch plant hollow capsule and a preparation method thereof, the capsule is easy to gel dry at low temperature, improves the utilization rate of production equipment, saves cost, and improves the performance of the capsule , but its disintegration time is long, and there are defects of brittleness at low temperature
[0005] CN103520729B discloses a vegetable capsule with 5-50wt% carrageenan and 50-95% Indian gum as molding aids, which promotes the disintegration of the capsule to a certain extent and enhances the toughness, but the high-temperature stability of the capsule Bad, low filling pass rate
[0006] CN103830737B discloses a starch-based hollow capsule, which uses a composition of locust bean gum and lentinan as a gelling agent to prepare a functional vegetable capsule, but the filling rate of the capsule is relatively low

Method used

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  • Starch-based empty capsule containing nonspecific immunity enhancer
  • Starch-based empty capsule containing nonspecific immunity enhancer
  • Starch-based empty capsule containing nonspecific immunity enhancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Mix 70g of hydroxypropyl wheat starch, 30g of Indian gum and pumpkin polysaccharide to obtain the basic raw materials for preparing hollow capsules, put the above-mentioned raw materials into an appropriate amount of water, heat and gelatinize, cool down, and then use traditional Empty capsules were prepared by dipping in glue. The prepared functional starch-based hollow capsules were tested for friability and disintegration according to the method stipulated in the second part of the Chinese Pharmacopoeia 2010 edition. The crushing degree can meet the requirements of the Pharmacopoeia; Tianda Tianfa ZB-1E intelligent disintegration instrument is used for disintegration experiments, and all test samples can be completely disintegrated within 6.0 minutes.

Embodiment 2

[0032] Mix 95g of hydroxyethyl cornstarch, 1.5g of Indian gum and 3.5g of pumpkin polysaccharide to obtain the basic raw materials for preparing hollow capsules, put the above-mentioned raw materials into an appropriate amount of water, heat and gelatinize, cool down, Then the hollow capsules are prepared by adopting the traditional glue-dipping process. The prepared functional starch-based hollow capsules were tested for friability and disintegration according to the method stipulated in the second part of the Chinese Pharmacopoeia 2010 edition. The crushing degree can meet the requirements of the Pharmacopoeia; Tianda Tianfa ZB-1E intelligent disintegration instrument is used for disintegration experiments, and all test samples can be completely disintegrated within 6.0 minutes.

Embodiment 3

[0034] Mix the composition of 82g of hydroxymethyl soybean starch, 6.8g of Indian gum and 10.2g of pumpkin polysaccharide to obtain the basic raw material for preparing hollow capsules, put the above-mentioned raw materials into an appropriate amount of water, heat and gelatinize, then cool down , and then prepare hollow capsules by adopting the traditional glue-dipping process. The prepared functional starch-based hollow capsules were tested for friability and disintegration according to the method stipulated in the second part of the Chinese Pharmacopoeia 2010 edition. The crushing degree can meet the requirements of the Pharmacopoeia; the disintegration test is carried out with Tianda Tianfa ZB-1E intelligent disintegration instrument, and all the test samples can be completely disintegrated within 5.9 minutes.

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Abstract

The invention discloses a starch-based empty capsule containing a nonspecific immunity enhancer. The starch-based empty capsule comprises components as follows: 5wt%-30wt% of a gelling agent and 70wt%-95wt% of modified starch, wherein the gelling agent is composition of gum ghatti and pumpkin polysaccharides. The prepared starch-based empty capsule has the advantages of short disintegration time, low friability at low temperature, high stability at high temperature and high filling pass rate and has a nonspecific immunity enhancement function.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular relates to a capsule widely used in medicine, health products and food industries, in particular to a starch-based hollow capsule containing a non-specific immune enhancer. Background technique [0002] It has a long history to prepare medicinal empty capsules by using gelatin hydrolyzed from collagen in animal skin and bone tissue, because the medicinal ingredients wrapped in hollow capsules can avoid the stimulation of the drug itself to the sensory organs of the human body, and achieve The effect of sustained release of drugs in the body, the empty capsules with gelatin as raw material have been widely used in the fields of medicine and food for a long time. As the main encapsulation material for medicines and health care products, its defects are gradually recognized by everyone. For example, the protein of the gelatin hollow capsule itself is easily affected by acid and alkal...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/36A61K31/715A61P37/04A61P39/00A23P10/30A23L29/212A23L29/25A23L33/125
CPCA23V2002/00A61K9/4816A61K31/715A61K36/42A61K47/36A23V2200/324A23V2250/5056A23V2250/51A23V2250/5118
Inventor 袁国卿闫丰文闫芳
Owner INST OF CHEM CHINESE ACAD OF SCI
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