Application of artemisinin and/or iron chelating agent serving as parasite killing medicaments

A technology of iron chelating agent and artemisinin derivatives, applied in the field of life medical science, can solve the problems of lack of insecticidal mechanism and insecticidal technology, lack of anti-insect technology for malaria or schistosomiasis, and failure of anti-insect drugs

Inactive Publication Date: 2016-11-09
TONGJI UNIV
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Problems solved by technology

[0002] Both malaria and schistosomiasis are serious parasitic diseases in my country, and the cause of malaria or schistosomiasis is still unclear. Therefore, there is currently a lack of anti-insect technology for malaria or schistosomiasis and other pests
In partic...

Method used

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Embodiment

[0029] Oral administration of artemisinin, 1g for the first time, 0.5g after 6-8 hours, and 0.5g each on the second and third day, can effectively treat malaria. However, the emergence of resistant strains will gradually make the drug ineffective. For falciparum malaria, giving deferoxamine 100mg / (kgh) continuously for 72 hours can increase the negative conversion rate of Plasmodium. However, after stopping the drug, the patient may relapse. Therefore, the combination of the two drugs can form a complementarity and kill the parasites by strongly inhibiting the utilization of iron.

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Abstract

The invention relates to application of artemisinin and/or an iron chelating agent serving as parasite killing medicaments. According to the specific scheme, artemisinin is used as a killing medicament for ordinary parasites or iron chelating agent resistant parasites, or the iron chelating agent is used as a killing medicament for the ordinary parasites or artemisinin resistant parasites, or a combined medicament of artemisinin and the iron chelating agent serves as a killing medicament for the artemisinin resistant parasites or the iron chelating agent resistant parasites. Compared with the prior art, on the basis of the principle that artemisinin or derivatives thereof block iron utilization of organisms and the principle that the iron chelating agent blocks iron utilization of the organisms, artemisinin or derivatives thereof and the iron chelating agent are combined and selected for use, and the killing effect on artemisinin resistant strains or iron chelating agent resistant strains can be improved.

Description

technical field [0001] The invention belongs to the field of life medicine science, and in particular relates to the application of artemisinin and / or iron chelating agent as parasite insecticide. Background technique [0002] Both malaria and schistosomiasis are serious parasitic diseases in my country, and the cause of malaria or schistosomiasis is still unclear. Therefore, there is currently a lack of anti-insect technology for malaria or schistosomiasis and other pests. In particular, the spread of drug-resistant insect strains has led to the ineffectiveness of traditional insect-resistant drugs, posing a huge threat to human health. At present, there is a lack of insecticidal mechanisms and effective insecticidal techniques for resistant insects. . Contents of the invention [0003] The object of the present invention is to provide the application of artemisinin and / or iron chelating agent as a parasite insecticide in order to overcome the above-mentioned defects in ...

Claims

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Application Information

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IPC IPC(8): A61K31/366A61K31/133A61P33/12A61P33/06
CPCA61K31/133A61K31/366A61K2300/00Y02A50/30
Inventor 孙军
Owner TONGJI UNIV
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