5 results about "Iron Chelating Agents" patented technology

The invention provides piroctone derivatives as well as a preparation method and application thereof, and belongs to the technical field of medicines. The piroctone derivative is novel in structure and has good solubility, and the preparation method is simple. Experiments prove that compared with a positive control drug DFO, the piroctone derivative provided by the invention has extremely strong iron ion chelating ability, has better anti-inflammatory, antibacterial, fibroblast migration promoting activity and diabetes refractory wound healing promoting activity, and can stabilize HIF-alpha. The piroctone derivative provided by the invention has a very good application prospect in the aspect of being developed into a novel iron chelating agent and an HIF-alpha stabilizer drug which have the effects of resisting inflammation, inhibiting bacteria, promoting wound healing, relieving iron overload and the like.

This invention relates to the field of biomedical technology and discloses an amphiphilic nicotinamide adenine dinucleotide (NAD) + Couplings, nanomicelles and their applications. Amphiphilic NAD+ + Couplings have the following general structural formula: ; where NAD + R is a hydrophilic group, R is a hydrophobic antioxidant group, and phenylboronic acid derivative is the linking bond; R is selected from free radical scavengers, small molecule organoselenic compounds that mimic the function of glutathione peroxidase 4, iron chelating agents, 7-dehydrocholesterol, royal jelly acid, α-lipoic acid, oleic acid, or derivatives of the above molecules. In this invention, NAD... + Conjugates and their self-assembled nanomicelles possess functions such as promoting DNA repair, maintaining cellular homeostasis, and delaying aging. Simultaneously, nanomicelles can inhibit inflammation and oxidative stress, and can physically encapsulate hydrophobic active drugs, showing broad application prospects in inflammatory diseases, age-related diseases, organ damage, and the prevention and treatment of toxic side effects from chemotherapy drugs.

The present invention provides preservative compositions that can be used as preservatives in various compositions, including personal care formulations, and methods for increasing the efficacy of preservatives in final-use formulations. [Solution] (i) A preservative comprising an acid compound, a phenol compound, a sulfite, an iron chelating agent, an aromatic alcohol, a quaternary ammonium compound, a pyrone compound, a urea compound, an imidazole compound, an isothiazolinone compound, or a combination of two or more preservatives; and (ii) a preservative composition comprising a polyglycerol ester present in an amount that sufficiently increases the efficacy of the preservative compared to the preservative alone, and the amount of increase is greater than the additive effect of the biocidal activity of the preservative and the polyglycerol ester used alone, wherein the weight ratio of the polyglycerol ester to the preservative is in the range of 0.0001 to 2.0.

The application provides N-doped carbon quantum dots and a preparation method and application thereof. The N-doped carbon quantum dots are prepared by using ginsenoside, ethylenediamine and water as raw materials and by adopting a hydrothermal synthesis method. The N-doped carbon quantum dots have high biological safety, are mainly composed of carbon elements, are not doped with metal elements and have high biocompatibility. Compared with traditional iron chelating agents, the N-doped carbon quantum dots have strong ROS scavenging properties and have stronger therapeutic effects. The N-doped carbon quantum dots have good physical stability, and the N-doped carbon quantum dots in artificial cerebrospinal fluid do not change in physical properties obviously within 28 days. The preparation method of the N-doped carbon quantum dots has simple synthesis technology, low synthesis cost, does not produce reaction waste and is conducive to clinical transformation.

The present invention addresses the problem of providing a novel method for regenerating nerves using a drug. As a means for solving the problem, the present invention provides a nerve regeneration agent containing an iron chelating agent, and a nerve regeneration method that includes a step in which an iron chelating agent is applied ex vivo to tissue requiring nerve regeneration.