59 results about "Iron Chelating Agents" patented technology

A composition for treating a portion of a wellbore or a portion of a subterranean formation is provided, the composition comprising: (a) water; (b) a source of hydrogen peroxide, and (c) an activator for the source of hydrogen peroxide; wherein the pH of the composition is adjusted to be within an appropriate range for the type of activator. A method for treating a portion of a wellbore or a portion of a subterranean formation, the method comprising the steps of: forming or providing a composition comprising: (a) water; (b) a source of hydrogen peroxide, and (c) an activator for the source of hydrogen peroxide; wherein the pH of the composition is adjusted within an appropriate range for the type of activator; and introducing the composition through a wellbore to treat a portion of a wellbore or a portion of a subterranean formation. The activator can be a water-soluble alkanoyl-donor compound or a chelated transition metal. Preferably, the composition further comprises an iron chelating agent. The composition and method are adapted for breaking a viscosity increasing polymer, such as xanthan. The method has particular applications where the static temperature of the portion of the wellbore or the portion of the subterranean formation to be treated is less than 100° F. (38° C.).

The invention provides a high strength alloy round aluminium rod and a production method thereof. Liquid aluminium with the content of more than 99.5% is added into a smelting furnace, the temperature is controlled to be 760-800 DEG C; silicon and magnesium and iron chelating agent are added, wherein the content of Si is controlled to be less than or equal to 0.6%, the content of Mg is controlled to be 0.3-0.9%, and the content of Fe is controlled to be less than or equal to 0.3%; aluminium melt is prepared, nitrogen is utilized to blow powder refining agent into the solution for refining, the usage amount of refining agent is 1.2kg/ton, and the pressure of nitrogen which is led in is 0.05-0.4MPa, thus obtaining aluminium melt with higher purity; and continuous casting and tandem rolling are carried out on aluminium melt subject to standing, before casting, Al-Ti-B rod is added in a chute at the speed of 150mm/min, so as to carry out online grain refinement treatment on the aluminium melt; and the rolled wire is subject to solid solution strengthening by virtue of an atomization quenching channel. Compared with common pure aluminium electrician round aluminium rod, the Al-Si-Mg alloy round aluminium rod of the invention has the advantages that: tensile strength is improved by 56.5%, the maximum can reach 64.6%; corresponding elongation is increased by 200%, the maximum can reach 228%; and resistivity is increased by only 28%.

A composition for treating a portion of a wellbore or a portion of a subterranean formation is provided, the composition comprising: (a) water; (b) a source of hydrogen peroxide, and (c) an activator for the source of hydrogen peroxide; wherein the pH of the composition is adjusted to be within an appropriate range for the type of activator. A method for treating a portion of a wellbore or a portion of a subterranean formation, the method comprising the steps of: forming or providing a composition comprising: (a) water; (b) a source of hydrogen peroxide, and (c) an activator for the source of hydrogen peroxide; wherein the pH of the composition is adjusted within an appropriate range for the type of activator; and introducing the composition through a wellbore to treat a portion of a wellbore or a portion of a subterranean formation. The activator can be a water-soluble alkanoyl-donor compound or a chelated transition metal. Preferably, the composition further comprises an iron chelating agent. The composition and method are adapted for breaking a viscosity increasing polymer, such as xanthan. The method has particular applications where the static temperature of the portion of the wellbore or the portion of the subterranean formation to be treated is less than 100° F. (38° C.).

The invention discloses a conjugate of 5-aminolevulinic acid and 3-pyridone-4-ketone. The conjugate is a conjugate of the 5-aminolevulinic acid and the 3-pyridone-4-ketone as an iron chelating agent, and is an ALA-HPO conjugate; the structural formula of the ALA-HPO conjugate is shown in the description, wherein R is alkyl or substituent alkyl; R(minute) is from natural amino acids. The invention also discloses a preparation method of the ALA-HPO conjugate. The invention also discloses the use of the ALA-HPO conjugate, i.e., the ALA-HPO conjugate is used for preparing drugs for photodynamics therapy.

Disclosed are an aqueous cosmetic preparation including at least astaxanthin, 20 μg/L or more of iron ions, and an iron chelating agent, and a method for suppressing the decomposition of astaxanthin in which an iron chelating agent is included in an aqueous composition including at least astaxanthin and 20 μg/L or more of iron ions.

An environmentally responsible iron chelating additive and method for removing hydrogen sulfide or sulfide ions from drilling and packer fluids and preventing settling of precipitates. Iron chelating agents selected from the group consisting of ferrous lactate, ferrous gluconate, ferrous bis glycinate, ferrous citrate, ferrous acetate, ferrous fumarate, ferrous succinate, ferrous sacchrate, ferrous tartarate, ferrous glycine sulfate, ferrous glutamate, ferrous ascorbate, ferrous polymaltose, or a combination thereof, may be used. When the fluids are oil based, the iron chelating agents are added to the water phase of an emulsion, and the emulsion is added to the fluid. Viscosifiers may also be added to the drilling fluid with the emulsion.

The invention relates to application of artemisinin and/or an iron chelating agent serving as parasite killing medicaments. According to the specific scheme, artemisinin is used as a killing medicament for ordinary parasites or iron chelating agent resistant parasites, or the iron chelating agent is used as a killing medicament for the ordinary parasites or artemisinin resistant parasites, or a combined medicament of artemisinin and the iron chelating agent serves as a killing medicament for the artemisinin resistant parasites or the iron chelating agent resistant parasites. Compared with the prior art, on the basis of the principle that artemisinin or derivatives thereof block iron utilization of organisms and the principle that the iron chelating agent blocks iron utilization of the organisms, artemisinin or derivatives thereof and the iron chelating agent are combined and selected for use, and the killing effect on artemisinin resistant strains or iron chelating agent resistant strains can be improved.

The invention relates to water-soluble fertilizer and a preparation method thereof. The water-soluble fertilizer comprises the following raw materials in parts by weight: 40 to 55 parts of monoammonium phosphate, 10 to 15 parts of ammonium sulfate, 5 to 10 parts of potassium sulphate, 20 to 25 parts of monopotassium phosphate, 0.35 to 1 part of a copper chelating agent, 0.35 to 1 part of a zinc chelating agent, 0.4 to 1.1 parts of an iron chelating agent, and 0.35 to 0.9 part of borax. The preparation method comprises the following steps: putting a nitrogen source, a phosphorus source and a potassium source into a dissolving tank, adding water to prepare paste, then putting the paste into another dissolving tank, adding microelements to prepare paste again, putting the produced paste intogranulation equipment to prepare semi-finished product fertilizer granules, performing drying, screening and cooling processes on the semi-finished product fertilizer granules, so as to obtain the finished product, namely the water-soluble fertilizer granules. The water-soluble fertilizer is low in production cost, high in water solubility, and complete in nutrient element coverage, realizes comprehensive utilization of waste, and eliminates environmental pollution.

The invention refers to an injectable antioxidant formulation for intravenous use comprising sodium ascorbate in high dosage as a first antioxidant agent, N-acetyl cysteine as a second oxidant agent and deferoxamine as an iron chelating agent, plus pharmaceutically acceptable excipients. And an administration method of said formulation that results in a synergic and improved effect to prevent injury due to reperfusion in an organ. In particular, to prevent injury due to early and late reperfusion in patients diagnosed with acute myocardium infarction and indication of primary coronary angioplasty. The invention further refers to the use of the formulation to prevent injury due to reperfusion in patients with acute myocardium infarction, subjected to primary coronary angioplasty.

The invention discloses an iron-containing chelating agent embedded MOF material, a synthesis method and application, the synthesis method comprises the steps of synthesizing the MOF material and synthesizing the iron-containing chelating agent embedded MOF material by taking the MOF material and ethylenediamine tetraacetic acid chelated iron as raw materials, encapsulating the ethylenediamine tetraacetic acid chelated iron in internal gaps of the MOF material to obtain the iron-containing chelating agent embedded MOF material. The adsorption performance of the MOF material is greatly improvedby utilizing a large number of chemical bonds easy for oxygen binding in ethylenediamine tetraacetic acid and the affinity of Fe element to oxygen, and the adsorbed material can be subjected to thermal desorption, so that the reutilization of the material is realized.

The invention discloses a use of a 3-hydroxy-4-pyridone high-molecular iron chelating agent. The 3-hydroxy-4-pyridone high-molecular iron chelating agent has antibacterial effects and can be used as an antibacterial material. The 3-hydroxy-4-pyridone high-molecular iron chelating agent has excellent effects of resisting methicillin-resistant staphylococcus aureus. According to a mechanism of cation simulative antibacterial peptide formation from tertiary amine or secondary amine positive ion structures in a high-molecular iron chelating agent, interaction between a positive charge area and a negative charge area on a cell membrane, and iron chelating effects of an iron chelating agent, the normal growth environment around bacteria is destroyed and bacterium growth is inhibited so that bacteria cannot normally grow. The 3-hydroxy-4-pyridone high-molecular iron chelating agent cannot be absorbed by skin because of macro-molecule characteristics, does not produce toxic or side effects and can be used as an antibacterial material with dual antibiosis effects.

The present invention provides a method for increasing metabolism and/or energy expenditure in a subject, e.g., to treat or prevent obesity and/or a related condition and/or to reduce adiposity, the method comprising increasing the level and/or activity of Hypoxia Induced Factor 1α (HIF-1α) in a cell, tissue or organ of the subject, thereby increasing metabolism in the subject. The present invention also provides a method for increasing metabolism in a subject, the method comprising administering an iron chelating agent to the subject, thereby increasing metabolism in the subject.

The invention discloses application of deferiprone in inhibition of ototoxicity of aminoglycoside drugs, and belongs to the field of drug-induced deafness. The invention discloses an application of deferiprone (DFP) in protection of hearing loss caused by aminoglycoside drugs. The DFP is the only oral active iron chelating agent and is clinically used for treating blood transfusion iron overload in thalassemia. According to the application, aminoglycoside drug damage, hair-like cells HEI-OC1 and mitochondrial autophagy occurrence levels in in-vitro cultured cochlea tissues are firstly researched, the protective effect of the DFP on the hair cells by regulating mitochondrial autophagy on the in-vitro cultured cochlea tissues is researched, and finally, the protective effect of the DFP on mouse hearing loss caused by aminoglycoside drugs is researched. A new thought is provided for treating drug-induced deafness, and a new target is provided for clinically helping a patient to recover and reconstruct an auditory function.

The invention relates to the technical field of biomedical materials, in particular to a preparation method and application of a BPN-DFO gel scaffold. Black phosphorus nanosheets (BPN) and deferoxamine (DFO) serve as bioactive components for promoting blood vessel and bone regeneration and are used for repairing ischemic bone defects, BPN can release controllable phosphorus, DFO serves as an iron chelating agent, angiogenesis can be promoted by activating vascular endothelial growth factors (VEGF) and other key angiogenesis promoting genes, and the effect of repairing ischemic bone defects is achieved. The gel scaffold prepared by the invention has good swelling, degradation and release rates, and has good biocompatibility. The BPN-DFO (black phosphorus nanosheet and deferoxamine) gel scaffold shows that the expression of mRNA (messenger ribonucleic acid) related to bone regeneration and cell proliferation is obviously up-regulated. In vivo, the BPN-DFO gel stent can significantly improve osteogenesis and neovascularization at the ischemic bone defect part.

The invention discloses a method for inhibiting fungal growth by adjusting calcium and iron contents and application thereof. The growth inhibition phenomenon of pathogenic fungi is caused by adding exogenous calcium in a low-iron environment, and it is proved that high calcium can inhibit absorption of fungi to iron, so that deletion of iron necessary for fungus growth is aggravated. According to the invention, the iron chelating agent is adopted to reduce the supply of iron nutrition, and calcium nutrition with a certain concentration is combined, so that the growth of aspergillus fumigatus can be obviously inhibited, and the inhibition effect is proved in an in-vitro culture medium and in a mouse body. The invention further finds that high-calcium and low-iron combined regulation can also inhibit pathogenic fungi-candida albicans and cryptococcus neoformans. The low-iron and high-calcium combined nutrition treatment technology disclosed by the invention can be popularized to control the growth of other types of pathogenic fungi such as plants, animals and the like, and is also effective to antifungal drug resistant strains.