Use of 3-hydroxy-4-pyridone high-molecular iron chelating agent
An iron chelating agent and polymer technology, which is applied in the field of 3-hydroxy-4-pyridone polymer iron chelating agents, can solve the problems of strong pathogenicity and multi-drug resistance, and achieves good compatibility and non-toxicity. Side effects, the effect of excellent antibacterial effect
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Embodiment 1
[0023] 0.2g polyglycidyl methacrylate PGMA1 (M n =12800g·mol -1 ) and 1.3g of 1-(amino-4,7,10-trioxytridecyl)-2-methyl-3-hydroxyl-4-(1H)-pyridone were added to a single-necked bottle, and then 8mL of anhydrous Dissolve N,N-dimethylformamide, then add 1 mL of triethylamine, keep at 55°C for 36 hours, add 80 mL of diethyl ether to the reaction liquid to precipitate the product, filter and dry the precipitate, put it into a dialysis bag for dialysis for 3 days (daily Change water four times, dialysis bag molecular weight cut-off is 3000) remove excess monomer and obtain macromolecular iron chelating agent 7K21, wherein the content of small molecular chelating agent in macromolecular iron chelating agent is about 70wt%. Dissolve 0.1 g of 7K21 in 1 mL of water, acetone, methyl ethyl ketone, N,N-dimethylformamide, and dimethyl sulfoxide to form a solution without any insoluble matter remaining in the solution. Calculate the number of repeating units in the polyglycidyl ether ester...
Embodiment 2
[0026] 0.2g polyglycidyl methacrylate PGMA2 (M n =10300g·mol -1) and 0.29g of 1-methylaminopropyl-2-methyl-3-hydroxyl-4-(1H)-pyridone were added to a one-necked bottle, then 8mL of anhydrous N,N-dimethylformamide was added to dissolve, and then Add 1 mL of triethylamine, keep it at 80°C for 2 hours, add 80 mL of diethyl ether to the reaction liquid to precipitate the product, filter the precipitate and dry it, put it into a dialysis bag for dialysis for 3 days (change distilled water four times a day, the molecular weight cut-off of the dialysis bag is 3000) Excessive monomers were removed to obtain the high-molecular iron chelating agent 8K41, wherein the content of the small-molecular chelating agent in the high-molecular iron chelating agent was about 58 wt%.
[0027] If other conditions remain unchanged, 0.2g of PGMA2 and 0.29g of 1-methylaminopropyl-2-methyl-3-hydroxyl-4-(1H)-pyridone in the reactant are replaced by 0.2g of polyglycidyl methacrylate Ether ester PGMA1, 0...
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