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Use of 3-hydroxy-4-pyridone high-molecular iron chelating agent

An iron chelating agent and polymer technology, which is applied in the field of 3-hydroxy-4-pyridone polymer iron chelating agents, can solve the problems of strong pathogenicity and multi-drug resistance, and achieves good compatibility and non-toxicity. Side effects, the effect of excellent antibacterial effect

Active Publication Date: 2015-11-11
UNIV OF SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because of its wide transmission route, it is easy to cause outbreaks in hospitals; and because of its strong pathogenicity and multi-drug resistance, it has become a difficult point in clinical treatment

Method used

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  • Use of 3-hydroxy-4-pyridone high-molecular iron chelating agent
  • Use of 3-hydroxy-4-pyridone high-molecular iron chelating agent
  • Use of 3-hydroxy-4-pyridone high-molecular iron chelating agent

Examples

Experimental program
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Effect test

Embodiment 1

[0023] 0.2g polyglycidyl methacrylate PGMA1 (M n =12800g·mol -1 ) and 1.3g of 1-(amino-4,7,10-trioxytridecyl)-2-methyl-3-hydroxyl-4-(1H)-pyridone were added to a single-necked bottle, and then 8mL of anhydrous Dissolve N,N-dimethylformamide, then add 1 mL of triethylamine, keep at 55°C for 36 hours, add 80 mL of diethyl ether to the reaction liquid to precipitate the product, filter and dry the precipitate, put it into a dialysis bag for dialysis for 3 days (daily Change water four times, dialysis bag molecular weight cut-off is 3000) remove excess monomer and obtain macromolecular iron chelating agent 7K21, wherein the content of small molecular chelating agent in macromolecular iron chelating agent is about 70wt%. Dissolve 0.1 g of 7K21 in 1 mL of water, acetone, methyl ethyl ketone, N,N-dimethylformamide, and dimethyl sulfoxide to form a solution without any insoluble matter remaining in the solution. Calculate the number of repeating units in the polyglycidyl ether ester...

Embodiment 2

[0026] 0.2g polyglycidyl methacrylate PGMA2 (M n =10300g·mol -1) and 0.29g of 1-methylaminopropyl-2-methyl-3-hydroxyl-4-(1H)-pyridone were added to a one-necked bottle, then 8mL of anhydrous N,N-dimethylformamide was added to dissolve, and then Add 1 mL of triethylamine, keep it at 80°C for 2 hours, add 80 mL of diethyl ether to the reaction liquid to precipitate the product, filter the precipitate and dry it, put it into a dialysis bag for dialysis for 3 days (change distilled water four times a day, the molecular weight cut-off of the dialysis bag is 3000) Excessive monomers were removed to obtain the high-molecular iron chelating agent 8K41, wherein the content of the small-molecular chelating agent in the high-molecular iron chelating agent was about 58 wt%.

[0027] If other conditions remain unchanged, 0.2g of PGMA2 and 0.29g of 1-methylaminopropyl-2-methyl-3-hydroxyl-4-(1H)-pyridone in the reactant are replaced by 0.2g of polyglycidyl methacrylate Ether ester PGMA1, 0...

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Abstract

The invention discloses a use of a 3-hydroxy-4-pyridone high-molecular iron chelating agent. The 3-hydroxy-4-pyridone high-molecular iron chelating agent has antibacterial effects and can be used as an antibacterial material. The 3-hydroxy-4-pyridone high-molecular iron chelating agent has excellent effects of resisting methicillin-resistant staphylococcus aureus. According to a mechanism of cation simulative antibacterial peptide formation from tertiary amine or secondary amine positive ion structures in a high-molecular iron chelating agent, interaction between a positive charge area and a negative charge area on a cell membrane, and iron chelating effects of an iron chelating agent, the normal growth environment around bacteria is destroyed and bacterium growth is inhibited so that bacteria cannot normally grow. The 3-hydroxy-4-pyridone high-molecular iron chelating agent cannot be absorbed by skin because of macro-molecule characteristics, does not produce toxic or side effects and can be used as an antibacterial material with dual antibiosis effects.

Description

1. Technical field [0001] The present invention relates to the application of a chelating agent, in particular to the application of a 3-hydroxy-4-pyridone polymer iron chelating agent. 2. Background technology [0002] Antibacterial materials refer to a new class of functional materials that have the function of killing or inhibiting microorganisms. They have extremely broad application prospects in the medical field, household products, household appliances, food packaging and other fields. Today, people's requirements for environmental hygiene are increasing day by day. The application of antibacterial materials has received more extensive attention. At present, antibiotics are commonly used in antibacterial and bactericidal materials in China, such as o-phenylphenol, methylisothiazolinone, and dichlorophenoxychlorophene. kind has no effect. Nowadays, the abuse of antibiotics has reached a very serious level. The abuse of antibiotics will lead to the emergence of highly...

Claims

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Application Information

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IPC IPC(8): A61K31/795A61P31/04
Inventor 张兴元李军配杨树罗伯特·海德文森索·阿巴特孔小乐贺晨张国庆
Owner UNIV OF SCI & TECH OF CHINA
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