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A kind of Danshen granule and its traditional Chinese medicine preparation

A technology of salvia miltiorrhiza and granules, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, plant raw materials, etc., can solve problems such as inability to meet real-time analysis of multi-variety, multi-batch samples, physical injury of inspectors, information feedback lag, etc. Achieve the effect of process parameters and easy control, high accuracy and stable process parameters

Active Publication Date: 2017-08-22
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the quality of traditional Chinese medicine formula granules will also be restricted by detection methods. The traditional determination of moisture in Danshen granules requires several hours with reference to the pharmacopoeia, and the operation is more complicated.
The main chemical component of Danshen Granules is salvianolic acid B. As a quality control indicator, the traditional method uses high-performance liquid chromatography, etc., which often requires complicated pretreatment of samples, consumes a large amount of reagents, causes great environmental pollution and is harmful to inspection. Due to the physical injury of the staff, the information feedback is lagging behind, which cannot meet the needs of real-time analysis of multi-variety and multi-batch samples in the process of large-scale production of granule enterprises

Method used

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  • A kind of Danshen granule and its traditional Chinese medicine preparation
  • A kind of Danshen granule and its traditional Chinese medicine preparation
  • A kind of Danshen granule and its traditional Chinese medicine preparation

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Preparation of Salvia miltiorrhiza granules: (1) Take Danshen decoction pieces, add water to decoct 3 times, add 8 times of water each time, and decoct for 1.5 hours each time; the medicinal liquids are combined, and the filtrate is concentrated to a clear liquid with a relative density of 1.08 (80°C). Paste, filter while hot with a 350 mesh sieve, take the clear paste and carry out spray drying to obtain dry powder of salvia miltiorrhiza by water extraction and spraying; (2) preparation of dry powder of salvia miltiorrhiza by alcohol extraction: take Danshen decoction pieces, add 8 times of 70% ethanol for the first time to reflux Extract for 1.5 hours, recover ethanol from the medicinal solution under reduced pressure, concentrate to a clear paste with a relative density of 1.07 (70° C.), and obtain Danshen ethanol clear paste A. Add 8 times the amount of water for the second time, heat and decoct for 1.5 hours, and the filtrate Concentrate to a clear paste with a rela...

Embodiment 2

[0034] The preparation of the traditional Chinese medicine preparation containing Danshen granules: (1) Take the slices of Danshen decoction, add water to decoct 3 times, add 8 times of water each time, and decoct for 1.5 hours each time; ℃) clear paste, filter it with a 350 mesh sieve while it is hot, take the clear paste and carry out spray drying to obtain the water-extracted dry powder of Salvia Miltiorrhiza Reflux extraction with 70% ethanol for 1.5 hours, recover ethanol from the medicinal liquid under reduced pressure, concentrate to a clear paste with a relative density of 1.07 (70°C), and obtain Danshen ethanol clear paste A, add 8 times the amount of water for the second time, heat and decoct After 1.5 hours, the filtrate was concentrated to a clear paste with a relative density of 1.08 (80°C) to obtain Danshen ethanol clear paste B, combined Danshen ethanol clear paste A and Danshen ethanol clear paste B, and the clear paste was spray-dried to obtain Danshen alcohol ...

Embodiment 3

[0036] A method for rapidly detecting the moisture content of Danshen granules based on near-infrared spectroscopy, specifically comprising the following steps:

[0037] a. Take samples of Salvia miltiorrhiza granules, a total of 155 batches, about 3g each, grind into fine powder, put it into a stoppered glass sample bottle, place it on a near-infrared scanner for scanning, collect spectra, scanning conditions: scanning range 4000 -12000cm -1 , number of scans: 32 times, resolution 8cm -1 , the background is subtracted in real time during the scanning process, and 3 spectra are collected for each sample to obtain the following figure 1 The near-infrared original absorption spectrum of 155 batches of Salvia miltiorrhiza shown;

[0038] At the same time, according to the standard method stipulated in the 2015 edition of the Chinese Pharmacopoeia, its moisture content was determined by drying method. About 2 g of Danshen granules that were ground into fine powder were spread fl...

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Abstract

The invention discloses a salvia miltiorrhiza granule and a traditional Chinese medicine preparation thereof. The salvia miltiorrhiza granule is prepared according to a preparation method comprising the following steps: (1) preparing powder of salvia miltiorrhiza through water extraction and spray drying; (2) preparing powder of salvia miltiorrhiza through alcohol extraction and spray drying; (3) mixing the powder obtained through water extraction and spray drying and the powder obtained through alcohol extraction and spray drying according to a proportion to obtain a mixture, and preparing the salvia miltiorrhiza granule of which the granularity is 16 to 40 meshes through dry granulation. The preparation process of the salvia miltiorrhiza granule is simple; the process parameters are easy to control; the invention further provides a detection method which is scientific, fast and strong in maneuverability.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, in particular to a Danshen granule and a traditional Chinese medicine preparation. Background technique [0002] Salvia miltiorrhiza is the dry root and rhizome of Salvia miltiorrhiza Bge., a plant of the Labiatae family. It is bitter, slightly cold, and has the effects of promoting blood circulation and removing blood stasis, clearing the meridian and relieving pain, clearing the heart and eliminating troubles, cooling blood and eliminating carbuncle. [0003] Traditional Chinese medicine granules are a series of traditional Chinese medicine products made of traditional Chinese medicine decoction pieces that meet the processing specifications, which are extracted, concentrated, dried, and granulated by modern industry. The new form of decoction pieces replaces the decoction pieces of traditional Chinese medicine for clinical syndrome differentiation and treatmen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/359A61K36/537A61K9/16G01N21/3563
CPCA61K9/1682A61K36/537A61K2236/331A61K2236/39A61K2236/51G01N21/3563G01N21/359G01N2021/3572
Inventor 刘丽萍霍文杰李国卫林振东王闽予陈向东谭登平程学仁
Owner GUANGDONG YIFANG PHARMA
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