A kind of red peony granule and its traditional Chinese medicine preparation

A technology of granules and Radix Paeoniae Alba, applied in the field of Radix Paeoniae Alba and its traditional Chinese medicine preparations, can solve the problems of quality restriction, physical injury of inspectors, and large consumption of reagents, etc., and achieve the effects of realizing quality control, shortening detection time, and reducing workload.

Active Publication Date: 2017-08-22
山东一方制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the quality of traditional Chinese medicine formula granules will also be restricted by detection methods. The traditional determination of water and ethanol extracts in Chishao granules requires several hours by referring to the pharmacopoeia, and the operation is more complicated.
The main chemical component of Chishao Granules is paeoniflorin. As a quality control index, the traditional method uses high-performance liquid chromatography, etc., which often requires complicated pretreatment of samples, consumes a lot of reagents, and pollutes the environment and inspectors. The body is damaged, and the information feedback is lagging behind, which cannot meet the needs of real-time analysis of multi-variety and multi-batch samples in the process of large-scale production of granule enterprises

Method used

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  • A kind of red peony granule and its traditional Chinese medicine preparation
  • A kind of red peony granule and its traditional Chinese medicine preparation
  • A kind of red peony granule and its traditional Chinese medicine preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Preparation of Radix Paeoniae Rubra Granules: Take Radix Radix Radix Paeoniae Alba, add water to decoct twice, add 8 times the amount of water each time, heat and decoct for 1.5 hours each time; combine the medicinal liquids, concentrate the filtrate to a clear paste with a relative density of 1.08, and decoct it while hot Filter with a 350-mesh sieve; spray dry under the conditions of air inlet temperature 150-190°C, material pump speed 600 rpm, outlet air temperature 85°C, and air supply temperature 40°C to obtain spray-dried powder; Aperture diameter 1.50mm, roller motor frequency 40HZ, feeding motor frequency 50HZ, oil cylinder pressure 18bar under the conditions of dry granulation, and the particle size is 40 mesh red peony granules.

Embodiment 2

[0036] The preparation of the traditional Chinese medicine preparation containing Radix Paeoniae Rubra granules: take Radix Radix Radix Radix Paeoniae Alba, decoct 2 times with water, add 8 times the amount of water each time, heat and decoct for 1.5 hours each time; The paste is filtered with a 350-mesh sieve while it is hot; it is spray-dried under the conditions of an inlet air temperature of 150-190°C, a material pump speed of 600 rpm, an outlet air temperature of 85°C, and an air supply temperature of 40°C to obtain a spray-dried powder; The hole diameter of the punching plate is 1.50mm, the frequency of the roller motor is 40HZ, the frequency of the feeding motor is 50HZ, and the oil cylinder pressure is 18bar, and the dry granulation is carried out to obtain the Chishao granules with a particle size of 40 mesh. Mix 120g of Radix Paeoniae Rubra granules with 80g of maltodextrin, add appropriate amount of magnesium stearate, mix evenly, and press into 1000 tablets.

Embodiment 3

[0038] A method for rapidly detecting the water content of Chishao granules based on near-infrared spectroscopy, specifically comprising the following steps:

[0039] a. Take red peony granule samples, a total of 63 batches, about 3g each, grind into fine powder, put it into a stoppered glass sample bottle, place it on a near-infrared scanner for scanning, collect spectra, scanning conditions: scanning range 4000-12000cm -1 , number of scans: 32 times, resolution 8cm -1 , the background is subtracted in real time during the scanning process, and 3 spectra are collected for each sample to obtain the following figure 1 The near-infrared original absorption spectrum of 63 batches of Chishao granules shown;

[0040] At the same time, according to the standard method specified in the 2015 edition of the Chinese Pharmacopoeia, its moisture content was measured by the drying method. About 2 g of the Radix Paeoniae Rubra granules that were ground into fine powder were spread flat in...

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Abstract

The invention discloses radix paeoniae rubra particles and a traditional Chinese medicine preparation thereof. The radix paeoniae rubra particle preparation method comprises: taking radix paeoniae rubra decoction pieces, adding water and decocting 1-2 times, and carrying out heating decocting for 1-2 h, wherein 5-10 times of the water is added each time; combining the drug solutions, concentrating the filtrate to obtain an extract with a relative density of 1.02-1.10, and filtering with a 250-350 mesh sieve while hot; taking the extract, and carrying out spay drying to obtain dry powder; and carrying out dry granulation on the dry powder to obtain the radix paeoniae rubra particles with a particle size of 16-40 mesh. According to the present invention, the radix paeoniae rubra particle preparation method has advantages of simple process and easy process parameter control, and the detection method is scientific and fast, and has strong operability.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to Chishao Granules and traditional Chinese medicine preparations. Background technique [0002] This product is the dried root of Paeonia lactiflora Pall. or Paeonia veitchiiLynch, a plant of the Ranunculaceae family. It is bitter, slightly cold, and returns to the liver meridian. It has the effects of clearing heat and cooling blood, dispelling stasis and relieving pain. . [0003] Traditional Chinese medicine granules are a series of traditional Chinese medicine products made of traditional Chinese medicine decoction pieces that meet the processing specifications, which are extracted, concentrated, dried, and granulated by modern industry. The new form of decoction pieces replaces the decoction pieces of traditional Chinese medicine for clinical syndrome differentiation and treatment, addition and subtraction according to the syndrom...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/359A61K36/71A61K36/65A61K9/16
CPCA61K9/1605A61K36/65A61K36/71A61K2236/331A61K2236/39A61K2236/51G01N21/359
Inventor 刘丽萍霍文杰朱德全黄小丹王闽予陈向东谭登平程学仁
Owner 山东一方制药有限公司
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