Hyaluronic acid anti-aging composition and preparation method and application thereof

A technology of hyaluronic acid and hyaluronate, which is applied in the preparation of hyaluronic acid anti-aging composition and the field of hyaluronic acid anti-aging composition. High enzyme activity, no cytotoxic effect

Active Publication Date: 2016-11-23
BLOOMAGE BIOTECHNOLOGY CORP LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the problem that the performance of hyaluronic acid in anti-aging in the prior art is insufficient, the present application discloses a hyaluronic acid anti-aging effect that has remarkable anti-aging effects such as three-dimensional moisturizing, scavenging free radicals, cell repair, and restoring skin elasticity. aging composition

Method used

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  • Hyaluronic acid anti-aging composition and preparation method and application thereof
  • Hyaluronic acid anti-aging composition and preparation method and application thereof
  • Hyaluronic acid anti-aging composition and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Accurately weigh hydrolyzed sodium hyaluronate (enzyme-cut oligomeric hyaluronate, trade name HA) 6.0kg, molecular weight 5.4kDa; sodium hyaluronate Ⅰ 2.0kg, molecular weight 480kDa; sodium hyaluronate Ⅱ 2.0kg, molecular weight 1050kDa; respectively put into double-cone rotary vacuum dryer, turn on the machine, and rotate and mix for 1 hour. The mixed product is put into sterilized packaging materials (bottles, bags, aluminum-plastic packaging, etc.). The above operations are all carried out in a clean workshop.

Embodiment 2

[0038] Accurately weigh hydrolyzed sodium hyaluronate (enzyme-cut oligomeric hyaluronate, trade name HA) 6.2kg, molecular weight 7.0kDa; sodium hyaluronate Ⅰ 1.8kg, molecular weight 320kDa; sodium hyaluronate Ⅱ 2.0kg, molecular weight 1100kDa; respectively put into the double-cone rotary vacuum dryer, turn on the machine, and rotate and mix for 1 hour. The mixed product is put into sterilized packaging materials (bottles, bags, aluminum-plastic packaging, etc.). The above operations are all carried out in a clean workshop.

Embodiment 3

[0040] Accurately weigh hydrolyzed sodium hyaluronate (enzyme-cut oligomeric hyaluronate, trade name HA) 6.2kg, molecular weight 8.5kDa; sodium hyaluronate Ⅰ 2.0kg, molecular weight 230kDa; sodium hyaluronate Ⅱ 1.8kg, molecular weight 1500kDa; respectively put into the double-cone rotary vacuum dryer, turn on the machine, and rotate and mix for 1 hour. The mixed product is put into sterilized packaging materials (bottles, bags, aluminum-plastic packaging, etc.). The above operations are all carried out in a clean workshop.

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Abstract

The invention discloses a hyaluronic acid anti-aging composition and a preparation method and application thereof. The composition comprises a hydrolyzed hyaluronic acid and salts thereof and two hyaluronic acids with weight-average molecular weight and salts thereof. According to multiple tests of skin moisture content, skin elasticity, depth of wrinkles and the like, an optimum ratio with an obvious anti-aging effect is finally determined. The weight ratio of the hydrolyzed hyaluronic acid and salts thereof in the composition is 60-62%; the weight ratio of hyaluronic acid with low molecular weight and salts thereof in the composition is 18-20%; and the weight ratio of hyaluronic acid with high molecular weight and salts thereof in the composition is 18-20%. The composition has the anti-aging effects of three-dimensional moisturizing, scavenging free radicals, repairing cells, restoring skin elasticity and the like, and can be used in cosmetics and cleaning products of all the forms.

Description

technical field [0001] The invention relates to the technical field of hyaluronic acid and its derivatives, in particular to a hyaluronic acid anti-aging composition, and also to a preparation method and application of the hyaluronic acid anti-aging composition. Background technique [0002] Skin aging is manifested by loss of skin volume and elasticity. The loss of skin volume is caused by the dehydration and hardening of collagen and other skin fillers due to the loss of skin HA; and the loss of skin volume leads to rough skin, loss of elasticity, and wrinkles. Therefore, hyaluronic acid is essential for healthy and youthful skin. [0003] Hyaluronic acid (HA) is an acidic mucopolysaccharide, an unbranched polymer glycosaminoglycan composed of N-acetylglucosamine and D-glucuronic acid disaccharide repeating units, present in animal tissue cells In the stroma and in the capsule of some bacteria. Hyaluronic acid is widely used in medicine, cosmetics, food and other fields...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61Q19/00A61Q19/08
CPCA61K8/735A61Q19/00A61Q19/08
Inventor 冯宁黄思玲申凤同石艳丽郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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