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Use of trans-cinnamaldehyde for preparing medicine for treating ischemic stroke

A technology of trans-cinnamaldehyde and its use, which is applied in the field of trans-cinnamaldehyde as a drug for the treatment of ischemic stroke, to achieve the effect of increasing cell survival rate, reducing active oxygen content, and reducing apoptosis rate

Active Publication Date: 2019-07-02
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its protective effect on neurological injury diseases such as cerebral ischemic nerve injury and neurodegenerative diseases has not been reported so far, and its development as a drug for the treatment of ischemic stroke has extremely high potential value and social significance

Method used

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  • Use of trans-cinnamaldehyde for preparing medicine for treating ischemic stroke
  • Use of trans-cinnamaldehyde for preparing medicine for treating ischemic stroke
  • Use of trans-cinnamaldehyde for preparing medicine for treating ischemic stroke

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Trans-cinnamaldehyde is used as a medicine for treating ischemic stroke, wherein the molecular structural formula of trans-cinnamaldehyde is as shown in formula (1)

[0022]

[0023] Ischemic stroke refers to ischemic stroke in the acute stage or repair stage. Trans-cinnamaldehyde is applied in the cells in a pharmaceutically acceptable powder injection form, and the single application amount is 0.1 μmol / L.

Embodiment 2

[0025] Trans-cinnamaldehyde is used as a medicine for treating ischemic stroke, wherein the molecular structural formula of trans-cinnamaldehyde is as shown in formula (1)

[0026]

[0027] Ischemic stroke refers to ischemic stroke in the acute stage or repair stage. Trans-cinnamaldehyde is applied in cells in a pharmaceutically acceptable injection dosage form, and the single application dose is 1 μmol / L.

Embodiment 3

[0029] Trans-cinnamaldehyde is used as a medicine for treating ischemic stroke, wherein the molecular structural formula of trans-cinnamaldehyde is as shown in formula (1)

[0030]

[0031] Ischemic stroke refers to ischemic stroke in the acute stage or repair stage. The application of trans-cinnamaldehyde in the cells adopts a pharmaceutically acceptable oral dosage form, and the single application dose is 10 μmol / L.

[0032] The effect of trans-cinnamaldehyde can be verified by the following cell experiments:

[0033] 1 Experimental materials

[0034] Cultured PC-12 cells, methazolium blue (MTT) was purchased from Guangzhou Chemical Reagent Factory; microplate reader was purchased from Thermo Company; ROS assay kit: product of Nanjing Jiancheng Bioengineering Research Institute; MMP kit: Biyuntian reagent Company; AnnexinV-FITC Cell Apoptosis Detection Kit: Shanghai Beibo Biological Company. NO inhibitor L-NAME, PI3K inhibitor LY294002 (Sigma Company) laser confocal mic...

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Abstract

The invention discloses an application of trans-cinnamaldehyde to preparation of a medicine for treating cerebral arterial thrombosis. The protective effect and a possible mechanism of the trans-cinnamaldehyde for oxygen-glucose deprived PC-12 cells are explored by building an oxygen-glucose deprivation model. Experimental results indicate that cell survival rate is increased after oxygen-glucose deprivation reperfusion, and active oxygen in the cells is reduced. Besides, the trans-cinnamaldehyde can stabilize mitochondrial membrane potential and reduce the apoptosis rate of the PC-12 cells, which indicates that the protective effect of the trans-cinnamaldehyde is possibly related to oxidation resistance. The results prove that the trans-cinnamaldehyde has a protective effect on ischemic injury.

Description

technical field [0001] The invention relates to the application of trans-cinnamaldehyde, in particular to the application of trans-cinnamaldehyde as a drug for treating ischemic stroke. Background technique [0002] Ischemic brain disease, also known as ischemic stroke, is the third leading cause of adult death and the first leading cause of disability worldwide. At present, intravenous thrombolysis is considered to be the only effective and feasible treatment for stroke, but due to its strict treatment time window and the risk of intracranial hemorrhage, the patients who benefit from this treatment are very limited. Therefore, it is particularly important to find new solutions for stroke treatment. [0003] Research on the mechanism of cerebral ischemia-reperfusion injury has progressed rapidly in recent years. It is generally believed that cerebral parenchyma ischemia and hypoxia occur during cerebral ischemia, and the energy metabolism disorder caused by ischemia and hyp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/11A61P9/10
CPCA61K31/11
Inventor 余建强祁雪周茹汪静张万年牛刚
Owner NINGXIA MEDICAL UNIV
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