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External gel preparation, preparation method and application thereof

A technology of gel preparation and gel matrix, applied in the field of medical gel, can solve the problems of single effect, insignificant detoxification and antipruritic effect, unfavorable human health, etc., achieve obvious effect, improve bioavailability, and improve adverse reactions Effect

Active Publication Date: 2016-11-23
浙江科露宝食品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The anti-mosquito bite lotions or ointments on the market are relatively single in effect, detoxifying, relieving pain, or relieving itching, and the detoxification and antipruritic effects are not obvious. On the other hand, these lotions or ointments usually contain a certain amount of Chemical substances, not suitable for people with skin allergies or infants, harmful to human health

Method used

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  • External gel preparation, preparation method and application thereof
  • External gel preparation, preparation method and application thereof
  • External gel preparation, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0102] The preparation method of the gel preparation for external use is as follows:

[0103] (1) Dissolving 14 parts by weight of carbomer in 700 parts by weight of water, stirring evenly, and standing for 24 hours to obtain a gel matrix;

[0104] (2) the chitosan that takes by weighing 0.5 weight part is dissolved in the 2% acetic acid of 20 weight parts, obtains A liquid, takes by weighing 50 weight parts of Sophora flavescens and gallnut of 25 weight parts and dissolves in the water of 300 weight parts, obtains For liquid B, mix liquid A and liquid B, let stand for 24 hours, filter, and centrifuge at 4000r / min to obtain liquid C;

[0105](3) Weigh 1 part by weight of menthol and dissolve it in 16 parts by weight of absolute ethanol, add the dissolved menthol into liquid C, stir evenly, let stand for 10 minutes, then add 5 parts by weight of glycerin, and stir evenly , to obtain liquid D;

[0106] (4) Add liquid D into the gel matrix in step (1), and adjust the pH value t...

Embodiment 2

[0108] (1) The sodium carboxymethyl cellulose of 5 weight parts is dissolved in the water of 250 weight parts, stirs, and leaves standstill 24h, obtains gel matrix;

[0109] (2) the chitosan that takes 10 parts by weight is dissolved in the 2% acetic acid of 500 parts by weight, obtains A liquid, takes the Sophora flavescens of 11.21 parts by weight and gallnut of 8.79 parts by weight to be dissolved in the water of 350 parts by weight, obtains For liquid B, mix liquid A and liquid B, let stand for 24 hours, filter, and centrifuge at 3500r / min to obtain liquid C;

[0110] (3) Weigh 10 parts by weight of menthol and dissolve it in 100 parts by weight of absolute ethanol, add the dissolved menthol into liquid C, stir evenly, let stand for 10 minutes, then add 30 parts by weight of propylene glycol, and stir evenly , to obtain liquid D;

[0111] (4) Add liquid D into the gel matrix in step (1), and adjust the pH value to 6.5 with triethanolamine to obtain a gel preparation for e...

Embodiment 3

[0113] (1) Dissolving 12 parts by weight of pectin in 600 parts by weight of water, stirring evenly, and standing for 24 hours to obtain a gel matrix;

[0114] (2) the chitosan that takes by weighing 5 parts by weight is dissolved in the 2% acetic acid of 250 parts by weight, obtains A liquid, takes by weighing 30 parts by weight of Sophora flavescens and gallnut of 18 parts by weight and is dissolved in the water of 200 parts by weight, obtains For liquid B, mix liquid A and liquid B, let stand for 24 hours, filter, and centrifuge at 5000r / min to obtain liquid C;

[0115] (3) Weigh 6 parts by weight of menthol and dissolve it in 80 parts by weight of absolute ethanol, add the dissolved menthol into liquid C, stir evenly, let stand for 10 minutes, then add 18 parts by weight of glycerin, and stir evenly , to obtain liquid D;

[0116] (4) Add liquid D into the gel matrix in step (1), and adjust the pH value to 8 with triethanolamine to obtain a gel preparation for external use...

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Abstract

The invention discloses an external gel preparation, a preparation method and application thereof and in particular relates to an external gel preparation for controlling mosquito bite. The external gel preparation is mainly prepared from the following raw materials in parts by weight: 0.5-10 parts of chitosan, 20-75 parts of inflammation-diminishing traditional Chinese medicine extract, 1-10 parts of menthol, 5-40 parts of gel matrix material, and 600-1000 parts of acetic acid existing in an amount capable of completely dissolving chitosan and ethanol and water existing in an amount capable of completely dissolving menthol. The external gel preparation disclosed by the invention is prepared from traditional Chinese medicine components and non-toxic raw materials, is applied to skin, has obvious effects of killing bacteria and diminishing inflammation, relieving etching and pain and removing toxic materials, has small side effects to a human body and is non-irritating to skin, and is good in mosquito bite control effect and low in cost, and batch production can be realized.

Description

technical field [0001] The invention relates to the technical field of medical gels, in particular to an external gel preparation, a preparation method and its application, in particular to an external gel preparation for preventing mosquito bites. Background technique [0002] After summer comes, mosquitoes and insects begin to breed. Mosquito bites will cause itching and irritation to the skin. How to prevent mosquito bites has become a topic of concern. At present, people usually choose some topical sprays or ointments for relief. [0003] The anti-mosquito bite lotions or ointments on the market are relatively single in effect, detoxifying, relieving pain, or relieving itching, and the detoxification and antipruritic effects are not obvious. On the other hand, these lotions or ointments usually contain a certain amount of It is not suitable for people with skin allergies or infants, and it is harmful to human health. Studies have found that some traditional Chinese medi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/489A61K9/06A61K47/36A61K47/38A61K47/32A61P17/02A61P17/04A61P29/00A61P39/02A61K31/045A61K31/722A61K35/64
CPCA61K47/32A61K47/36A61K47/38A61K9/0014A61K9/06A61K31/045A61K31/722A61K35/63A61K36/489A61K2300/00
Inventor 林湧博刘楠董毅夫杨泽洪
Owner 浙江科露宝食品有限公司
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