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Compositions containing lutein/lutein esters and applications thereof

A technology of lutein ester and carotene, applied in medical preparations containing active ingredients, medical preparations with non-active ingredients, applications, etc., can solve the problem of reducing the bioavailability of lutein/lutein ester, leaf Lutein/lutein ester stability damage and other problems, to achieve significant health care and therapeutic effects, increase eye blood flow, high bioavailability effect

Active Publication Date: 2019-06-07
SINO NUTRACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Strong acids have a strong destructive effect on the stability of lutein / lutein esters. These products quickly enter the gastrointestinal tract after oral consumption, and the low pH (0.9-1.8) of gastric juice will greatly reduce the lutein / lutein Bioavailability of esters, the issue is not addressed in the prior art

Method used

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  • Compositions containing lutein/lutein esters and applications thereof
  • Compositions containing lutein/lutein esters and applications thereof
  • Compositions containing lutein/lutein esters and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Recipe: (weight)

[0029]

[0030]

[0031] Preparation:

[0032] The components are mixed and then prepared into orally disintegrating tablets by methods known in the art. Clinical Observation:

[0033] (1) Clinical data

[0034] A clinical trial was carried out on 220 outpatients. The clinical manifestations of these patients were dim eyesight, eye pain, weak dark adaptation, blurred vision, photophobia, dry eyes, and blinking. They were non-hospitalized and voluntarily participated in the experiment; 110 cases in the treatment group ( Male: female = 1:1), and 110 cases in the control group (male: female = 1:1).

[0035] (2) Treatment method

[0036] The control group used Zhenshiming Eye Drops, once a day, and 15 days was a course of treatment; the treatment group took the compound of the present invention orally, 550 mg / tablet, 4 tablets per day;

[0037] (3) The clinical trial results are as follows:

[0038]

[0039] There is a significant differenc...

Embodiment 2

[0041]

[0042] Clinical Observation:

[0043] (1) Clinical data

[0044] A clinical trial was carried out on 180 outpatients. The clinical manifestations of these patients were dim eyesight, eye pain, weak dark adaptation, blurred vision, photophobia, dry eyes, and blinking. They were non-hospitalized and voluntarily participated in the experiment; 100 cases in the treatment group ( Male: female = 1:1), and 80 cases in the control group (male: female = 1:1).

[0045] (2) Treatment method

[0046] The control group uses eye drops, once a day, and 15 days is a course of treatment; the treatment group takes orally the compound of the present invention, 550 mg / tablet, 4 tablets per day;

[0047] (3) The clinical trial results are as follows:

[0048]

[0049]

[0050] There are significant differences between the treatment group and the matched group, and it is concluded that the clinical application of the present invention has a significant curative effect.

[0051...

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Abstract

Disclosed in the present invention are a composition containing lutein / lutein ester and applications thereof. Components of the composition containing lutein / lutein ester comprise lutein / lutein ester, β-carotene and a pharmaceutically acceptable carrier. The weight ratio of lutein / lutein ester to β-carotene is 1:0.1-100. In the present invention, by cooperatively using lutein / lutein ester and β-carotene and using auxiliary natural healthy ingredients, the dosage form of an orally disintegrating tablet is prepared. The orally disintegrating tablet is absorbed through the oral cavity, has fast effectiveness and small first-pass effect, reduces damage of gastric acid to lutein / lutein ester, has high bioavailability, and has the characteristics of nutritional and health-care effects, good mouthfeel and fast absorption. By eating the product, visual power can be obviously enhanced, the ocular blood flow is increased, and eye muscle fatigue is alleviated, and accordingly the morbidities of cataract, senile niacula lutea retinae lesion and adolescent myopia are reduced.

Description

technical field [0001] The present invention relates to lutein / lutein ester preparations. Background technique [0002] In recent years, people's study, work and entertainment have become more and more dependent on computers, TVs, mobile phones and other video display terminal equipment. They often use their eyes excessively and do not pay attention to eye maintenance, which leads to vision loss and even induces various eye diseases. Great physical and mental pain. [0003] Lutein esters are natural antioxidants present in plant cells, which are metabolized into lutein in the human body. Lutein is considered to be the "vitamin of the eyes", which has a unique effect on preventing the incidence of cataracts, age-related macular degeneration and the occurrence of myopia in teenagers. Lutein also has anti-cancer, prevents the occurrence of cardiovascular diseases, enhances Body immunity and other health effects. [0004] At present, there are various health products, efferve...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/047A61K31/23A61K31/015A61P27/02A61P27/10A61P27/12
CPCA61K31/015A61K31/047A61K31/23A61K2300/00A23L33/105A23V2002/00A61K9/0056A61K31/07A61K47/02A61K47/12A61K47/26A61K47/40A61P27/02A61P27/10A61P27/12C07C403/24A23V2250/211A61K9/20
Inventor 顾茂健苏健梅
Owner SINO NUTRACEUTICAL CO LTD
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