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Water-in-oil-in-water emulsion, and application and use method thereof

A water-in-oil-in-water, emulsifier technology, applied in the direction of antiviral agents, pharmaceutical formulations, medical preparations containing active ingredients, etc., to achieve the effects of improving room temperature stability, high safety, and easy availability

Inactive Publication Date: 2017-01-04
彭建彪 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention aims to solve the problems described above

Method used

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  • Water-in-oil-in-water emulsion, and application and use method thereof
  • Water-in-oil-in-water emulsion, and application and use method thereof
  • Water-in-oil-in-water emulsion, and application and use method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1 Emulsifier X1

[0040] Emulsifier X1 includes: mineral oil 88 grams; polyethylene glycol 400 monooleate 9 grams; mannitol monooleate 3 grams.

[0041] Its method of use includes the following steps:

[0042] 1) Heat emulsifier X1 to 30°C;

[0043] 2) Take 130 grams of heated emulsifier X and put it into a 200mL beaker, and add another 30 grams of antigen (inactivated porcine foot-and-mouth disease virus) aqueous solution at 35°C to the beaker, and place the beaker under a mechanical stirrer after adding , keep stirring at a speed of 200 rpm for 15 minutes to make the emulsion uniform, and obtain the self-made vaccine emulsion 1.

[0044] The use of the emulsifier X1 is as an adjuvant for porcine foot-and-mouth disease vaccine.

Embodiment 2

[0045] Embodiment 2 Emulsifier X2

[0046] Emulsifier X2 includes: 85 grams of mineral oil; 9 grams of polyethylene glycol 400 monooleate; 3 grams of mannitol monooleate, and 3 grams of fatty alcohol polyoxyethylene ether.

[0047] Its method of use includes the following steps:

[0048] 1) Heat emulsifier X2 to 35°C;

[0049]2) Put 45 grams of heated emulsifier X2 into a 200mL beaker, and add another 30 grams of antigen (inactivated porcine foot-and-mouth disease virus) aqueous solution at 15°C to the beaker, and place the beaker on a mechanical stirrer after adding Keep stirring at a speed of 250 rpm for 15 minutes to make the emulsion uniform, and obtain the self-made vaccine emulsion 2.

[0050] The use of the emulsifier X2 is as an adjuvant for porcine foot-and-mouth disease vaccine.

Embodiment 3

[0051] Embodiment 3 Emulsifier X3

[0052] Emulsifier X3 includes: 82 grams of mineral oil; 9 grams of polyethylene glycol 400 monooleate; 3 grams of mannitol monooleate, and 3 grams of fatty alcohol polyoxyethylene ether.

[0053] Its method of use includes the following steps:

[0054] 1) Heat emulsifier X3 to 30°C;

[0055] 2) Put 40 grams of the heated emulsifier X3 into a 200mL beaker, and add another 30 grams of an aqueous solution of antigen (inactivated porcine foot-and-mouth disease virus) at 20°C to the beaker, and place the beaker on a mechanical stirrer after adding Keep stirring at a speed of 225 rpm for 12 minutes to make the emulsion uniform, and obtain the self-made vaccine emulsion 3.

[0056] The use of the emulsifier X3 is as an adjuvant for porcine foot-and-mouth disease vaccine.

[0057] The emulsifying agent of the present invention includes many kinds, because the raw material of each component and the selection of mass percentage are different, the f...

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Abstract

The invention provides a water-in-oil-in-water emulsion, and an application and a use method thereof. The water-in-oil-in-water emulsion comprises the following components by mass percent: 70-98wt% of oil phase, 1-29wt% of hydrophilic surface active agent and 1-29wt% of lipophilic surface active agent, wherein the hydrophilic surface active agent comprises one or more of polyethylene glycol 264 monoleate, polyethylene glycol 400 monoleate and polyethylene glycol 600 monoleate. The emulsion provided by the invention has the beneficial effects of ultrahigh stability and high stability of vaccine solution under room temperature. A research proves that the stability of the emulsion provided by the invention is equivalent to the stability of ISA206 adjuvant.

Description

technical field [0001] The invention relates to a water-in-oil-in-water emulsifier and its application and application method. Background technique [0002] There are many types of adjuvants, and there is no unified classification method at present. Commonly used adjuvants can be divided into four categories: inorganic adjuvants, such as aluminum hydroxide, alum, etc.; organic adjuvants, microorganisms and their products, etc.; synthetic adjuvants, such as Artificially synthesized double-stranded polynucleotides (double-stranded polyadenylic acid, uridine acid), levamisole, isoprinosine, etc.; oil adjuvants, such as Freund's adjuvant, peanut oil emulsification adjuvant, mineral oil , vegetable oil, etc. [0003] Oil adjuvants are currently the most commonly used in animals, and can be divided into two types: Freund's incomplete adjuvant and complete adjuvant. Incomplete adjuvant is made by mixing oil agent (paraffin oil or vegetable oil) with emulsifier, when it is mixed w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/39A61K39/135A61P31/14
CPCA61K39/135A61K39/39A61K2039/55511
Inventor 彭建彪
Owner 彭建彪
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