Water-dispersible oil-in-oil lipid nanocapsule and preparation method thereof
A technology of dispersibility and nanocapsules is applied in the field of preparation of water-dispersible oil-in-oil lipid nanocapsules, which can solve the problems of low bioavailability, irritating odor, poor water solubility and the like, and achieves simple preparation method, stable product quality, good water solubility
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Embodiment 1
[0020] Example 1: Lipoic acid and vitamin E oil-water dispersible oil-in-oil lipid nanocapsule preparation method
[0021]
[0022] Such as figure 1 Shown, the preparation steps of this embodiment are as follows:
[0023] 1. Weigh 0.42g of lipoic acid and 10g of vitamin E oil, put them into a 250ml beaker, put them in a 60°C water bath and stir at 300r / min until completely mixed to obtain mixture I.
[0024] 2. Weigh 5g of phospholipid (PC50), 10g of dipropylene glycol to fully dissolve the phospholipid under 80°C temperature and stirring conditions, and add this mixture to the above mixture I, stir the mixture II in a 60°C water bath at 300r / min for 5min .
[0025] 3. Weigh 74.58g of glycerin and preheat it to 60°C, add it to the above mixture II, stir in a 60°C water bath at 300r / min for 5min, and mix to form a homogeneous solution to obtain mixture III.
[0026] 4. The above-mentioned mixture III is subjected to high-pressure homogenization treatment, the high-pressur...
Embodiment 2
[0028] Example 2: Lipoic acid and vitamin E oil-water dispersible oil-in-oil lipid nanocapsule preparation method
[0029]
[0030]
[0031] Such as figure 1 Shown, the preparation steps of this embodiment are as follows:
[0032] 1. Weigh 0.5g of lipoic acid and 10g of vitamin E oil, put them into a 250ml beaker, put them in a 60°C water bath and stir at 300r / min until completely mixed to obtain mixture I.
[0033] 2. Weigh 5g of phospholipid (PC60), 10g of dipropylene glycol to fully dissolve the phospholipid under 80°C temperature and stirring conditions, and add this mixture to the above mixture I, stir the mixture II in a 60°C water bath at 300r / min for 5min .
[0034] 3. Weigh 74.5g of glycerin and preheat it to 60°C, add it to the above mixture II, stir in a 60°C water bath at 300r / min for 5min, and mix to form a homogeneous solution to obtain mixture III.
[0035] 4. The above-mentioned mixture III is subjected to high-pressure homogenization treatment, the hi...
Embodiment 3
[0037] Example 3: Lipoic acid and vitamin E oil-water dispersible oil-in-oil lipid nanocapsule preparation method
[0038]
[0039] Such as figure 1 Shown, the preparation steps of this embodiment are as follows:
[0040] 1. Weigh 0.25g of lipoic acid and 5g of vitamin E oil, put them into a 250ml beaker, place them in a 60°C water bath and stir at 300r / min until completely mixed to obtain mixture I.
[0041] 2. Weigh 4.2g of phospholipid (PC60), 8.4g of dipropylene glycol to fully dissolve the phospholipid under 80°C temperature and stirring conditions, and add this mixture to the above mixture I, stir in a 60°C water bath at 300r / min for 5min Mixture II.
[0042] 3. Weigh 82.15g of glycerin and preheat it to 60°C, add it to the above mixture II, stir in a 60°C water bath at 300r / min for 5min, and mix to form a homogeneous solution to obtain mixture III.
[0043] 4. The above-mentioned mixture III is subjected to high-pressure homogenization treatment, the high-pressure...
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