Water-dispersible oil-in-oil lipid nanocapsule and preparation method thereof

A technology of dispersibility and nanocapsules is applied in the field of preparation of water-dispersible oil-in-oil lipid nanocapsules, which can solve the problems of low bioavailability, irritating odor, poor water solubility and the like, and achieves simple preparation method, stable product quality, good water solubility

Inactive Publication Date: 2017-01-11
SOUTHEAST UNIV
View PDF3 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although both lipoic acid and vitamin E have good antioxidant properties, their water solubility is poor, resulting in low bioavailability of both
In addition, because lipoic acid and vitamin E have strong antioxidant capacity, they are easily oxidized by oxygen in the air when exposed to the air, and lipoic acid will have a pungent smell after oxidation, so this has also become a bottleneck in application

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Water-dispersible oil-in-oil lipid nanocapsule and preparation method thereof
  • Water-dispersible oil-in-oil lipid nanocapsule and preparation method thereof
  • Water-dispersible oil-in-oil lipid nanocapsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Lipoic acid and vitamin E oil-water dispersible oil-in-oil lipid nanocapsule preparation method

[0021]

[0022] Such as figure 1 Shown, the preparation steps of this embodiment are as follows:

[0023] 1. Weigh 0.42g of lipoic acid and 10g of vitamin E oil, put them into a 250ml beaker, put them in a 60°C water bath and stir at 300r / min until completely mixed to obtain mixture I.

[0024] 2. Weigh 5g of phospholipid (PC50), 10g of dipropylene glycol to fully dissolve the phospholipid under 80°C temperature and stirring conditions, and add this mixture to the above mixture I, stir the mixture II in a 60°C water bath at 300r / min for 5min .

[0025] 3. Weigh 74.58g of glycerin and preheat it to 60°C, add it to the above mixture II, stir in a 60°C water bath at 300r / min for 5min, and mix to form a homogeneous solution to obtain mixture III.

[0026] 4. The above-mentioned mixture III is subjected to high-pressure homogenization treatment, the high-pressur...

Embodiment 2

[0028] Example 2: Lipoic acid and vitamin E oil-water dispersible oil-in-oil lipid nanocapsule preparation method

[0029]

[0030]

[0031] Such as figure 1 Shown, the preparation steps of this embodiment are as follows:

[0032] 1. Weigh 0.5g of lipoic acid and 10g of vitamin E oil, put them into a 250ml beaker, put them in a 60°C water bath and stir at 300r / min until completely mixed to obtain mixture I.

[0033] 2. Weigh 5g of phospholipid (PC60), 10g of dipropylene glycol to fully dissolve the phospholipid under 80°C temperature and stirring conditions, and add this mixture to the above mixture I, stir the mixture II in a 60°C water bath at 300r / min for 5min .

[0034] 3. Weigh 74.5g of glycerin and preheat it to 60°C, add it to the above mixture II, stir in a 60°C water bath at 300r / min for 5min, and mix to form a homogeneous solution to obtain mixture III.

[0035] 4. The above-mentioned mixture III is subjected to high-pressure homogenization treatment, the hi...

Embodiment 3

[0037] Example 3: Lipoic acid and vitamin E oil-water dispersible oil-in-oil lipid nanocapsule preparation method

[0038]

[0039] Such as figure 1 Shown, the preparation steps of this embodiment are as follows:

[0040] 1. Weigh 0.25g of lipoic acid and 5g of vitamin E oil, put them into a 250ml beaker, place them in a 60°C water bath and stir at 300r / min until completely mixed to obtain mixture I.

[0041] 2. Weigh 4.2g of phospholipid (PC60), 8.4g of dipropylene glycol to fully dissolve the phospholipid under 80°C temperature and stirring conditions, and add this mixture to the above mixture I, stir in a 60°C water bath at 300r / min for 5min Mixture II.

[0042] 3. Weigh 82.15g of glycerin and preheat it to 60°C, add it to the above mixture II, stir in a 60°C water bath at 300r / min for 5min, and mix to form a homogeneous solution to obtain mixture III.

[0043] 4. The above-mentioned mixture III is subjected to high-pressure homogenization treatment, the high-pressure...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a water-dispersible oil-in-oil lipid nanocapsule containing lipoic acid and vitamin E oil and a preparation method of the water-dispersible oil-in-oil lipid nanocapsule. The preparation method includes: sequentially evenly mixing, by weight percentage, 0.1-5% of the lipoic acid, 0.1-20% of vitamin E oil, 1-10% of phospholipid, 2-20% of dipropylene glycol, 50-80% of glycerin and the like at 40-80 DEG C, and performing high-pressure homogenizing treatment to obtain the transparent or semitransparent water-dispersible oil-in-oil lipid nanocapsule containing the lipoic acid and the vitamin E oil, wherein the particle size of the water-dispersible oil-in-oil lipid nanocapsule is 250 nanometers. The water-dispersible oil-in-oil lipid nanocapsule is simple to prepare, good in water dispersity, good in bioavailability, good in repeatability, and the like.

Description

technical field [0001] The invention relates to a method for preparing water-dispersible oil-in-oil lipid nanocapsules containing lipoic acid and vitamin E oil, and belongs to the technical field of cosmetics. Background technique [0002] Lipoic acid is a coenzyme that exists in the mitochondria, similar to vitamins. After being absorbed by the human body, it can be quickly converted into dihydrolipoic acid in the cell, and then excreted from the cell membrane to participate in the extracellular metabolic cycle. Lipoic acid and dihydrolipoic acid can scavenge almost all oxygen free radicals in the body. Lipoic acid is widely used in cosmetics and pharmaceutical and healthcare industries due to its strong oxidizing ability. In the medical and health care industry, lipoic acid is mainly used to treat diabetes and its complications, acute coronary syndrome, protect ischemia-reperfusion injury, strengthen liver function, and improve dementia. In the field of cosmetics, people...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/67A61K8/06A61K8/11A61Q19/00
CPCA61K8/678A61K8/06A61K8/11A61K8/673A61K2800/592A61Q19/00
Inventor 夏强刘田
Owner SOUTHEAST UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap