Detection chip of urine exfoliated tumor cells and application thereof

A tumor cell and detection chip technology, applied in the field of exfoliated tumor cell detection chip, can solve the problems of loss of tumor cells, lack of specificity, low sensitivity, etc., and achieve good application prospects

Inactive Publication Date: 2017-01-11
隗慧林
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are still problems in the existing technology: lack of specificity, low purity, some tumor cells may be lost during the separation process, the detection process is too dependent on the number of cells or the detection sensitivity is low

Method used

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  • Detection chip of urine exfoliated tumor cells and application thereof
  • Detection chip of urine exfoliated tumor cells and application thereof
  • Detection chip of urine exfoliated tumor cells and application thereof

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Experimental program
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Embodiment

[0034] see figure 1 , the present invention provides a urine exfoliation tumor cell detection chip 1, comprising a top plate 11, a bottom plate 12, and a channel plate 13 between the bottom plate 12 and the top plate 11; the channel plate 13 is provided with an exfoliated tumor cell The cell separation chamber is used for enriching exfoliated tumor cells in urine.

[0035]As mentioned above, it can be understood that the urine exfoliation tumor cell detection chip 1 is a microfluidic chip, which integrates or basically integrates the basic operation units involved in the fields of biology and chemistry, such as sample preparation, biological and chemical reactions, separation and detection, etc. A technology for completing different biological or chemical reaction processes and analyzing their products on a chip of square centimeters. It is an important technical platform for the research of signal detection and processing methods in life science and chemical science. It has...

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Abstract

The invention provides a detection chip of urine exfoliated tumor cells. The detection chip of the urine exfoliated tumor cells comprises a top plate, a bottom plate and a channel plate located between the bottom plate and the top plate; an exfoliated tumor cell separation chamber is arranged in the channel plate, and used for enriching the exfoliated tumor cells in urine. The detection chip of the urine exfoliated tumor cells integrates separation, enrichment and detection, exfoliated tumor cell markers are used as objects to be detected, and a rapid detection method is established, and has the characteristics of specificity, sensitivity, cheap price, convenient carrying and the like. The detection chip of the urine exfoliated tumor cells has better prospects in aspects of clinical applications of noninvasive diagnosis, therapeutic monitoring, recurrence early-warning and the like of patients with urinary system cancers.

Description

technical field [0001] The invention belongs to the field of cell detection, and in particular relates to an exfoliated tumor cell detection chip and its application. Background technique [0002] Common tumors of the urinary system mainly include kidney cancer, bladder cancer and prostate cancer. Renal cancer accounts for about 2% to 3% of adult malignant tumors and 80% to 90% of adult renal malignant tumors. The incidence rate varies from country to country or region in the world. In general, the incidence rate in developed countries is higher than that in developing countries, and in urban areas is higher than in rural areas. There are more men than women. The ratio of male to female patients is about 2:1. The age of onset can vary. Seen in all age groups, the highest incidence age is 50 to 70 years old. Bladder cancer refers to malignant tumors that occur on the bladder mucosa. It is the most common malignant tumor in the urinary system and one of the ten most common t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/34C12M1/00B01L3/00C12Q1/02
CPCC12M47/04B01L3/5027B01L2200/10C12M23/16C12M41/40G01N33/5005
Inventor 隗慧林
Owner 隗慧林
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