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Solid formulations containing omega-3 and resveratrol

A technology of resveratrol and omega, applied in medical preparations containing active ingredients, medical preparations with non-active ingredients, anti-inflammatory agents, etc., can solve problems such as ineffective acquisition

Active Publication Date: 2017-02-22
阿尔法西格玛股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ineffective in achieving the desired purpose even with the addition of specific emulsifiers and / or co-surfactants

Method used

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  • Solid formulations containing omega-3 and resveratrol
  • Solid formulations containing omega-3 and resveratrol
  • Solid formulations containing omega-3 and resveratrol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0051] example

[0052] Materials and methods:

[0053] For the purposes of the present invention, the following materials were used:

[0054] Omega-3 polyunsaturated fatty acids (n-3PUFA) are mixtures of ethyl esters of polyunsaturated fatty acids, which are produced by Pronova, Norway, with EPA and DHA content greater than 85%, and EPA / DHA ratio between 0.9 and 1.5 between;

[0055] Resveratrol was provided by Royalmount Pharmaceuticals (Montreal, Canada);

[0056] The magnesium aluminum silicate used is also known It was provided by Fuji Chemical Industry Co., Ltd, Japan;

[0057] · Tocopherol was provided by Sigma-Aldrich S.r.l (Milan, Italy);

[0058] · Syloid XDP was provided by Grace Performance Chemicals (Worms, Germany);

[0059] Coenzyme Q10 was provided by Sigma-Aldrich S.r.l (Milan, Italy);

[0060]· Ascorbyl palmitate was provided by Sigma-Aldrich S.r.l (Milan, Italy);

[0061] Lipoic acid was provided by Sigma-Aldrich S.r.l (Milan, Italy);

[0062] · A...

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Abstract

The present application relates to invention a solid composition comprising omega-3 polyunsaturated fatty acids (n-3 PUFA), or their alkyl esters, and resveratrol, adsorbed on an inert substrate and wherein the recovery of omega-3 is at least 96% after 6 months at 25 degrees centigrade. The composition according to the present invention can be formulated as food supplement or medicament for preventing or treating cardiovascular diseases due to lipid metabolism disorders and increased platelets aggregation; damages due to free radicals selected from the group consisting of atherosclerosis, cancer, inflammatory joint disease, asthma, diabetes, senile dementia and degenerative eye disease; and / or viral diseases.

Description

technical field [0001] The present invention relates to a solid composition comprising omega-3 polyunsaturated fatty acids (n-3 PUFA) and resveratrol or a natural extract comprising resveratrol adsorbed on an inert matrix, wherein the composition remains stable at room temperature 6 months. [0002] Specifically, the present invention relates to the use of the above solid and stable composition for the prevention or treatment of cardiovascular diseases caused by disorders of lipid metabolism and increased platelet aggregation, damage caused by free radicals and / or viral diseases. Background technique [0003] In industrialized countries, cardiovascular disease involving abnormal lipid metabolism occurs frequently. For example, according to the data released by the World Health Organization in April 2011, in Italy, the death toll of cardiovascular diseases reached 18.65% of the overall death toll. What we know about the relationship between resveratrol and coronary heart di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/202A61K47/02A61K47/04A61K47/10A61K9/48A61P9/00A61P39/06A61P31/12A61P9/10A61P35/00A61P29/00A61P11/06A61P3/10A61P25/28A61P27/02
CPCA61K9/485A61K9/4858A61K31/202A61K47/02A61K47/10A61K9/0053A61K9/1611A61K9/167A61K31/05A61P11/06A61P19/02A61P25/28A61P27/02A61P29/00A61P31/12A61P35/00A61P3/06A61P39/06A61P7/02A61P9/00A61P9/10A61P3/10A61K2300/00
Inventor G·詹尼尼M·圣阿涅洛
Owner 阿尔法西格玛股份有限公司