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Nutritional composition for improving mammalian immune system

A nutritional composition and mammalian technology, applied in the field of compositions for improving the immune function of mammals, can solve problems such as poor quality of life, decreased immune function, and changes in patients' established treatment plans

Active Publication Date: 2011-07-20
NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Second, the presence of infectious complications can lead to changes in the patient's established treatment regimen (eg, surgery or medical therapy (eg, chemotherapy) can be delayed)

Method used

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  • Nutritional composition for improving mammalian immune system
  • Nutritional composition for improving mammalian immune system
  • Nutritional composition for improving mammalian immune system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0156] Materials and methods

[0157] Animals and diet. 6- to 7-week-old syngeneic male CD2F1 mice (BALB / c x DBA / 2) were obtained from Harlan Nederland (Horst, The Netherlands). All experimental methods were approved by the Animal Experimental Committee and followed the principles of laboratory animal care. Animals are housed individually in a climate-controlled animal care facility with constant room temperature and humidity. All animals had free access to food and water. Animals were acclimatized for one week upon arrival and then randomized based on body weight. The experiments were divided into: A-experiments, designed to test the effect of individual ingredients, and B-experiments, designed to test the effect of complete mixtures with similar ingredients to the composition according to the invention. In both experiments A-experiment and B-experiment, mice were divided into a control group (C) receiving a control diet, a tumor-bearing control group (TB) receiving a cont...

Embodiment 2

[0180] Decreased hepatic glutathione levels have been shown in cancer cachexia mice ( image 3 ). image 3 The total hepatic GSH of the control group (C group), the tumor-bearing group (TB) and the nutritional combination group (F2G) receiving a diet having the same composition as that of the TB-SNC group in Example 1 are shown. Results are plotted as mean + std (nmol / mg dry weight) on the left of the graph and as dots on the right of the graph. For tumor bearing group (TB) vs control group: p=0.001. For nutrition combination group (F2G) vs tumor-bearing group: p=0.042. Statistical test using Mann-Whitney test (Mann-Whitney). In experiments using an in vitro model of normal liver, it was demonstrated that glutamine and cysteine ​​have a positive effect on glutathione homeostasis in hepatic HepG2 cells ( Figure 4 ). It has also been demonstrated that giving tumor-bearing mice a glutamine- and cysteine-rich nutrition containing whey (rich in cysteine) and casein (rich in g...

Embodiment 3

[0182] In this experiment, the effect of oral administration of a combination of nutrients on Pseudomonas aeruginosa infection in C3H / HeN mice receiving chemotherapy was investigated.

[0183] Materials and methods

[0184] Female C3H / HeN mice (Charles River, Netherlands) were 7-8 weeks old at the start of the experiment. The animals were housed individually in ventilated cages (IVC) and all animal handling was performed in a laminar flow hood. The installation features a 12:12 dark:light cycle, a constant room temperature of 21±2°C, and a humidity of 50+5%. Animals were acclimatized for 1 week after arrival.

[0185] These animals received diets C and FC-2G containing the same composition as the control diet (C; n=18) and supplemented TB-SNC diet (FC-2G; n=18) in Experiment B of Example 1. In addition, a group of animals received diet C without chemotherapy (group CT-C; n=8) to demonstrate that infection did not occur without chemotherapy.

[0186] Pseudomonas aeruginosa ...

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Abstract

The invention relates to a nutritional composition comprising (a) at least 18 en% of proteinaceous matter; (b) at least 12 wt% of leucine, based on total proteinaceous matter: (C) a lipid fraction comprising at least an omega-3 polyunsaturated fatty acid selected from the group of eicosapentaenoic acid, docosahexaenoic acid, eicosatetraenoic acid and docosapentaenoic acid; and (d) an immune modulator; for improving the immune function in a mammal, preferably a human.

Description

technical field [0001] The present invention relates to a composition comprising a proteinaceous substance comprising leucine, an omega-3 polyunsaturated fatty acid and an immunomodulator. [0002] The present invention also relates to the use of the composition suitable for improving the immune function of mammals. Background technique [0003] The main function of the immune system in mammals is to protect the body from pathogenic infection and eradicate malignant cells (precancerous cells). Immune function is multilayered and involves many different cell types. Physical and chemical barriers constitute the first layer of defense against pathogens, a particularly important aspect in the mucosal epithelium such as the gastrointestinal lining (cells). In addition to immune cells, non-immune cells such as epithelial cells play an important role in the first layer of defense. The innate immune system, primarily composed of natural killer (NK) cells, phagocytic leukocytes su...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61K35/20A61K38/17A23L1/305A61P37/04
CPCA23V2002/00A61K31/702A61K31/202A61K38/02A61K35/20A61K31/198A23L1/3051A23L1/3008A23L1/296A23L1/3056A61K38/018A61K45/06A61K39/39A23L33/12A23L33/175A23L33/19A23L33/40A61K47/12A61K47/42A61K2039/55583A61P31/00A61P37/02A61P37/04A61K2300/00A23V2250/54252A23V2250/54246A23V2250/0628A23V2250/28A23V2250/1868A23V2250/187A23V2200/324
Inventor 霍伊塞·法贝尔阿德里安乌斯·拉姆贝图斯·贝特霍尔德斯·范赫尔福尔特克拉斯克·范诺伦阿简·保罗·福斯罗伯特·约翰·约瑟夫·哈格曼科内鲁斯·约翰内斯·彼得鲁斯·范利姆普特
Owner NUTRICIA
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