Nutritional composition for improving mammalian immune system
A nutritional composition and mammalian technology, applied in the field of compositions for improving the immune function of mammals, can solve problems such as poor quality of life, decreased immune function, and changes in patients' established treatment plans
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Embodiment 1
[0156] Materials and methods
[0157] Animals and diet. 6- to 7-week-old syngeneic male CD2F1 mice (BALB / c x DBA / 2) were obtained from Harlan Nederland (Horst, The Netherlands). All experimental methods were approved by the Animal Experimental Committee and followed the principles of laboratory animal care. Animals are housed individually in a climate-controlled animal care facility with constant room temperature and humidity. All animals had free access to food and water. Animals were acclimatized for one week upon arrival and then randomized based on body weight. The experiments were divided into: A-experiments, designed to test the effect of individual ingredients, and B-experiments, designed to test the effect of complete mixtures with similar ingredients to the composition according to the invention. In both experiments A-experiment and B-experiment, mice were divided into a control group (C) receiving a control diet, a tumor-bearing control group (TB) receiving a cont...
Embodiment 2
[0180] Decreased hepatic glutathione levels have been shown in cancer cachexia mice ( image 3 ). image 3 The total hepatic GSH of the control group (C group), the tumor-bearing group (TB) and the nutritional combination group (F2G) receiving a diet having the same composition as that of the TB-SNC group in Example 1 are shown. Results are plotted as mean + std (nmol / mg dry weight) on the left of the graph and as dots on the right of the graph. For tumor bearing group (TB) vs control group: p=0.001. For nutrition combination group (F2G) vs tumor-bearing group: p=0.042. Statistical test using Mann-Whitney test (Mann-Whitney). In experiments using an in vitro model of normal liver, it was demonstrated that glutamine and cysteine have a positive effect on glutathione homeostasis in hepatic HepG2 cells ( Figure 4 ). It has also been demonstrated that giving tumor-bearing mice a glutamine- and cysteine-rich nutrition containing whey (rich in cysteine) and casein (rich in g...
Embodiment 3
[0182] In this experiment, the effect of oral administration of a combination of nutrients on Pseudomonas aeruginosa infection in C3H / HeN mice receiving chemotherapy was investigated.
[0183] Materials and methods
[0184] Female C3H / HeN mice (Charles River, Netherlands) were 7-8 weeks old at the start of the experiment. The animals were housed individually in ventilated cages (IVC) and all animal handling was performed in a laminar flow hood. The installation features a 12:12 dark:light cycle, a constant room temperature of 21±2°C, and a humidity of 50+5%. Animals were acclimatized for 1 week after arrival.
[0185] These animals received diets C and FC-2G containing the same composition as the control diet (C; n=18) and supplemented TB-SNC diet (FC-2G; n=18) in Experiment B of Example 1. In addition, a group of animals received diet C without chemotherapy (group CT-C; n=8) to demonstrate that infection did not occur without chemotherapy.
[0186] Pseudomonas aeruginosa ...
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