Preparation of photothermal diagnosis and treatment agent based on gadolinium modified Fe3O4@ PDA nano material

Abstract

The invention discloses preparation of a photothermal diagnosis and treatment agent based on a gadolinium modified Fe3O4@ PDA nano material, and belongs to a preparation technology of a novel nano composite material. A T1 contrast agent Gd-DTPA and a T2 contrast agent Fe3O4 which have been applied clinically and PDA which has good biological compatibility and near infrared absorbing ability are used; Fe3O4 nano particles with sizes about 10 nanometers are synthesized by a coprecipitation method, and PDA wraps the surfaces of the Fe3O4 nano particles to obtain the Fe3O4@ PDA nano material with good monodispersity; in order to connect Gd-DTPA with the Fe3O4 nano particles, Fe3O4@ PDA is subjected to amination, and finally, the required Fe3O4@ PDA-NH2-DTPA-Gd nano composite material is obtained. Experimental results prove that the material simultaneously has good T1 and T2 imaging effect and photothermal conversion ability.

Description

technical field [0001] The invention belongs to the preparation technology of novel nanocomposite materials, and in particular relates to the preparation of a photothermal diagnosis and treatment agent of gadolinium-modified Fe3O4@PDA nanomaterials. Background technique [0002] At present, the clinical diagnosis and treatment of tumors face two major problems. First, the three cancer treatment methods currently used clinically include surgery, radiotherapy and chemotherapy, but the treatment effect is not good, and what's worse, they have the risk of causing a second primary cancer, and cancer patients often Suffer great pain and side effects; Second, the diagnosis and treatment of tumors are separated, therefore, the dynamic change process of tumors cannot be monitored during the treatment of tumors, which will cause inaccurate evaluation of efficacy and time lag. In view of the above problems, at present, the development of new imaging-guided cancer treatment methods has...

AI Technical Summary

Problems solved by technology

For example, studies have shown that metal-based nanoparticles cannot be degraded in the body, and metals themselves have toxicity problems

And carbon materials will produce many toxic side effects, such as oxidative stress and lung infection, etc.

Zheng's group used the ligand formed by porphyrin compounds and lipids as monomers to prepare such a photothermal therapy agent by self-assembly method. Since porphyrin is a natural compound, the obtained porphysomes nanoparticles can be degraded in vivo , and will not cause severe acute poisoning, but the preparation of this type of material is very cumbersome and requires pre-synthesis of organic ligands

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