Quality control method of peach kernel qi activating decoction composition

A quality control method, the technology of Chengqi Decoction, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of few indicators, many medicinal flavors, single quality control, etc., and achieve the effect of objective conclusion, convenient operation, and quality control of preparations

Active Publication Date: 2017-03-08
CHINA RESOURCES SANJIU MEDICAL & PHARMA +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to overcome that the traditional Chinese medicine compound preparation in the prior art basically has only one or two index components in content control, single quality control, few indicators, and it is difficult to fully reflect the many flavors of medicines, many components, and many targets. The defect of the quality status of the Taohe Chengqi Decoction composition, thereby providing the quality control method of the Taohe Chengqi Decoction composition

Method used

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  • Quality control method of peach kernel qi activating decoction composition
  • Quality control method of peach kernel qi activating decoction composition
  • Quality control method of peach kernel qi activating decoction composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] Example 1: Preparation of Taohe Chengqi Decoction Composition

[0091] The first peach core Chengqi soup composition: take by weight the following pieces of decoction pieces, 12g of peach kernels, 12g of rhubarb, 6g of licorice root, 6g of cinnamon sticks, 6g of Glauber's salt; four-flavored pieces (except Glauber's salt) are placed in 4L casserole, Add 1400ml of water, soak for 30 minutes, cover, use the sogo heating plate as the heating device, boil (about 25min), keep a slight boil (about 85 minutes, evaporation about 10g / min) to about 500ml of decoction, use two-layer medical Filter out the dregs with gauze, add Glauber's salt, and boil.

[0092] The second Taohe Chengqi Decoction composition: weigh the following pieces by weight: 1000g of peach kernels, 1000g of rhubarb, 500g of cinnamon sticks, 500g of mirabilite, and 500g of licorice; four-flavor pieces (except mirabilite), add 8 times the amount of Water, decocted for 1.5h to obtain a filtrate; Glauber's salt...

Embodiment 2

[0093] Example 2. Determination of free anthraquinone content in Taohe Chengqi Decoction composition by HPLC

[0094] (1) Chromatographic conditions and system applicability

[0095] Use octadecylsilane-bonded silica gel as filler; acetonitrile as mobile phase A, 0.1% phosphoric acid as mobile phase B, gradient elution; detection wavelength is 254 nm. The number of theoretical plates should not be less than 3000 calculated according to the emodin peak, flow rate: 1.0ml / min, column temperature: 30℃.

[0096] Gradient elution procedure

[0097]

[0098] (2) Preparation of reference solution

[0099] Accurately weigh appropriate amounts of aloe-emodin reference substance, rhein acid reference substance, emodin reference substance, chrysophanol reference substance, and emodin methyl ether reference substance, and add methanol to prepare each 1ml containing aloe-emodin, rhein, emodin, A solution of 80 μg of chrysophanol and 40 μg of emodin methyl ether; respectively, accurate...

Embodiment 3

[0113] Example 3. Determination of total anthraquinone content in Taohe Chengqi Decoction composition by HPLC

[0114] (1) Chromatographic conditions and system applicability

[0115] Use octadecylsilane-bonded silica gel as filler; methanol as mobile phase A, 0.1% phosphoric acid as mobile phase B, gradient elution; detection wavelength is 254 nm. The number of theoretical plates should not be less than 3000 calculated according to the peak of emodin, flow rate: 0.8ml / min, column temperature: 30℃.

[0116] Gradient elution procedure

[0117]

[0118] (2) Preparation of reference solution

[0119] Accurately weigh appropriate amounts of aloe-emodin reference substance, rhein acid reference substance, emodin reference substance, chrysophanol reference substance, and emodin methyl ether reference substance, and add methanol to prepare each 1ml containing aloe-emodin, rhein, emodin, A solution of 80 μg of chrysophanol and 40 μg of emodin methyl ether; respectively, accura...

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Abstract

The invention discloses a quality control method of a peach kernel qi activating decoction composition and belongs to the field of traditional Chinese medicine analysis. The method includes the steps that a peach kernel qi activating decoction fingerprint spectrum is established through high performance liquid chromatography, and chromatographic conditions are characterized in that a chromatographic column adopts octadecylsilane chemically bonded silica as filler; an ultraviolet detector is adopted as a detection instrument, and the detection wavelength of the fingerprint spectrum ranges from 210 nm to 250 nm; the flow rate ranges from 0.9 ml/ml to 1.1 ml/ml, the column temperature ranges from 25 DEG C to 35 DEG C, the detection wavelength ranges from 210 nm to 250 nm, the number of theoretical plates should not be smaller than 3,000 according to calculation of catechinic acid peaks, methyl alcohol serves as a moving phase A, a 0.1% phosphoric acid solution serves as a moving phase B, and gradient elution is carried out according to the following sequence: the gradient condition of elution detection of the fingerprint spectrum is defined in the specification. The fingerprint spectrum comprehensively reflects quality information of a peach kernel qi activating decoction, and therefore the quality of the peach kernel qi activating decoction can be more comprehensively and effectively controlled.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine analysis, and particularly relates to a quality control method for a Taohe Chengqi Decoction composition. Background technique [0002] Traditional Chinese medicine decoction is the mainstream of clinical medicine, but due to the inconvenience of decoction and portability, the quality of decoction prepared by decoction often varies greatly depending on the person and the decoction utensils. It is popular among consumers because of its convenience, convenience, testing and low-cost. Using modern science and technology to develop traditional Chinese medicine preparations that are convenient to carry and take, it is not only the inheritance of traditional Chinese medicine, but also a better promotion of classic famous prescriptions. Clinical application. The preparation process of granules is relatively simple, easy to shape, easy to take and carry, and is the most consistent with traditi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/06G01N30/60G01N30/74
CPCG01N30/06G01N30/6052G01N30/74
Inventor 陈世彬虢小翊陈周全刘志刚谭沛马鹏岗丁苗苗刘志东
Owner CHINA RESOURCES SANJIU MEDICAL & PHARMA
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