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Neuralgia treating medicine composition and application thereof

A composition and technology for neuralgia, applied in the field of medicine, can solve problems such as many side effects, and achieve the effects of reducing the administration concentration, reducing the risk, and improving the use effect.

Inactive Publication Date: 2017-03-15
THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is a lack of satisfactory safe and effective neuropathic pain drugs in clinical practice (Pain, 2013, 154:213-220). ) and norepinephrine (NE) reuptake, N-methyl-D-aspartate (NMDA) receptor antagonism and sodium ion channel blockade, after diabetes-induced NNP and herpes zoster Neuralgia is the most researched and has definite curative effect, but there are many side effects (Journal of Pharmaceutical Practice, 2016,34:309-311)

Method used

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  • Neuralgia treating medicine composition and application thereof
  • Neuralgia treating medicine composition and application thereof
  • Neuralgia treating medicine composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Method for making neuropathic pain model

[0017] The neuropathic pain model was prepared by spinal nerve ligation (segmental spinal nerve ligation, SNL). The mice were anesthetized by intraperitoneal injection of 2% chloral hydrate (0.2mL / l0g). After the righting reflex disappeared, the mice were fixed in the prone position. The method of Kim and Chung was used to make the model: a median skin incision about 3-5 cm long was bluntly separated from the L4-S2 level on the back of the mouse, the paravertebral muscles were separated to the sixth lumbar process, and the right L5 / L6 joint was exposed and excised The L5 nerve was gently separated and tightly ligated with 5-0 silk suture. Then the incision was sutured layer by layer, the skin was disinfected with povidone iodine, and the feeding continued. The gait of the animals was abnormal after the operation, and the hindlimb of the operated side had no other deformity except for mild valgus and toes tightening.

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Abstract

Disclosed are a neuralgia treating medicine composition and application thereof. The neuralgia treating medicine composition is composed of amitriptyline hydrochloride and ZL006 methyl ester at a weight ratio of 1: (3-6). Amitriptyline hydrochloride can block nervous centralis from reuptaking of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) as well as receptor antagonism and sodium channel retardation of N methyl D aspartate (NMDA); ZL006 methyl ester can decouple PSD95-nNOS to avoid generation of too much NO; when applied in an appropriate proportion, amitriptyline hydrochloride and ZL006 methyl ester can achieve enhancement or synergistic effects and accordingly improve the use effects. Under the premise of gaining equal therapeutic effects, the risk of adverse effects can be reduced due to application concentration reduction of amitriptyline hydrochloride.

Description

technical field [0001] The invention belongs to the field of medicine and provides a medicine composition for treating neuralgia and application thereof. Background technique [0002] Neuropathic pain is "pain that results directly from damage or disease affecting the somatosensory system." Epidemiological surveys show that 7%-8% of people have experienced neuropathic pain in their lifetime (Pain, 2008, 136:380-387). It is a disease that is difficult to treat and has great harm to humans (Physical Medicine and Rehabilitation Clinics of North America 2013, 24, 507-520). Neuropathic pain is a continuous process that may recur and requires long-term treatment. At present, there is a lack of satisfactory safe and effective neuropathic pain drugs in clinical practice (Pain, 2013, 154:213-220). ) and norepinephrine (NE) reuptake, N-methyl-D-aspartate (NMDA) receptor antagonism and sodium ion channel blockade, after diabetes-induced NNP and herpes zoster Neuropathic pain has bee...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/618A61K31/135A61P25/00A61P29/00
CPCA61K31/135A61K31/618A61K2300/00
Inventor 程志祥夏波周晓徐培魏晨晨李飞
Owner THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIV
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