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Preparation method and pharmaceutical application of effective part of rhodiola rosea

An effective part, Rhodiola rosea technology, applied in the field of medicine, to achieve reliable drug efficacy, promote the repair and protection of vascular endothelial cells, and stabilize the supply of raw materials

Inactive Publication Date: 2017-03-22
QINGHAI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these drugs can improve patients' dyspnea, 6-minute walk distance (6MWD) and pulmonary hemodynamics, they have different shortcomings in terms of therapeutic effect, preparation and drug cost, and treatment convenience.

Method used

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  • Preparation method and pharmaceutical application of effective part of rhodiola rosea
  • Preparation method and pharmaceutical application of effective part of rhodiola rosea
  • Preparation method and pharmaceutical application of effective part of rhodiola rosea

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Use the dried rhizome of Rhodiola tangutica as the original drug, crush it and extract it 3 times with 95% ethanol under reflux. , the filtrate was concentrated under reduced pressure to recover ethanol until there was no alcohol smell, and the extract was obtained; add 5 times the amount of water for water precipitation, stand at 5°C for 24 hours, filter the precipitate, separate the filtrate through D101 macroporous adsorption resin, and use pure water , 30% ethanol, and 70% ethanol were eluted in three gradients, and the eluate of 70% ethanol was concentrated under reduced pressure, and the effective fraction of Rhodiola tangutica was obtained after freeze-drying.

Embodiment 2

[0033] Use the dry rhizome of Rhodiola rosea as the original drug, crush it and extract it 3 times with 100% ethanol under reflux, each time the dosage is 10 times the weight of the original drug, and the extraction time is 2 hours each time. Concentrate the filtrate under reduced pressure to recover ethanol until there is no alcohol smell to obtain the extract; add 10 times the amount of water for water precipitation, stand at 15°C for 24 hours, filter the precipitate, separate the filtrate through HP20 macroporous adsorption resin, and use pure water, Four gradients of 30% ethanol, 70% ethanol, and 95% ethanol were used for elution, the eluate of 70% ethanol was concentrated under reduced pressure, and the effective fraction of Rhodiola rosea was obtained after freeze-drying.

Embodiment 3

[0035] Use the dried rhizome of Rhodiola Hima as the original drug, crush it and extract twice with 10% ethanol under reflux, each time the dosage is 5 times the weight of the original drug, and the extraction time is 1 hour each time, combine the extracts and filter, and the filtrate Concentrate under reduced pressure to recover ethanol until there is no alcohol smell to obtain extract; add 5 times the amount of water for water precipitation, stand at 20°C for 12 hours, filter the precipitate, separate the filtrate through HPD macroporous adsorption resin, and use pure water, 70 % ethanol, 95% ethanol three gradients for elution, the eluate of 70% ethanol was concentrated under reduced pressure, and the effective fraction of Rhodiola Hima was obtained after freeze-drying.

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Abstract

The invention discloses a preparation method and pharmaceutical application of an effective part of rhodiola rosea. The preparation method comprises the following steps that the rhodiola rosea is extracted by ethanol after being smashed; and an extract is subjected to separation through macroporous adsorption resin and gradient elution through water and ethanol systems, an eluent is subjected to decomperssion concentration, and after freeze drying, the effective part of the rhodiola rosea is obtained. According to the application of the effective part of the rhodiola rosea, the effective part is used for preparing medicine for treating and / or preventing pulmonary arterial hypertension, health care products for treating and / or preventing the pulmonary arterial hypertension, medicine for promoting vascular endothelial cell repair and protection, health care products for promoting vascular endothelial cell repair and protection, medicine for treating cell line grain damage, and health care products for treating cell line grain damage. The raw material supply of the effective part is stable, the cost is low, the preparation cost is low, and the medicine effect is reliable.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an effective part of Rhodiola rosea isolated from roots of plants of the genus Rhodiola and its use in the preparation of medicines and health care products for treating pulmonary hypertension. Background technique [0002] Rhodiola is a plant of the genus Rhodiola (Crassulaceae), which is a perennial herb or subshrub plant. There are more than 90 species. There are 73 species in my country. They are mainly produced in North China, Northeast China, Southwest China, Northwest China and central China have abundant reserves, ranking first in the world. Qinghai is one of the main production areas of Rhodiola rosea, and Rhodiola annus Rhodiola Kirilowii and rhodiola tangut Rhodiola algida Large storage capacity. Rhodiola rosea has a long history of medicinal use in our country. "Compendium of Materia Medica" praised it as "Eight Treasure Grass", "Flame Grass", and "Top Grade in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/41A23L33/105A61P9/12A61P9/14A61P43/00
CPCA23V2002/00A61K36/41A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55A23V2200/326A23V2250/21
Inventor 芦殿香李占强苏姗姗靳国恩格日力南星梅王喜萌马小冬马可吴萍杨全余嘎琴
Owner QINGHAI UNIVERSITY
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