R language-based optimal extraction technology for extracting saponin and total flavonoids in liquorice

A technology of glycyrrhizin and total flavonoids, applied in gene models, medical preparations containing active ingredients, biological neural network models, etc., can solve the problems of low extraction efficiency and less simultaneous extraction of licorice flavonoids and saponins
CN106511448AInactive Publication Date: 2017-03-22ZHEJIANG CHINESE MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG CHINESE MEDICAL UNIVERSITY
Publication Date
2017-03-22
Estimated Expiration
Not applicable ยท inactive patent

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Abstract

The invention discloses an R language-based optimal extraction technology for extracting saponin and total flavonoids in liquorice. A central composite design experiment in a response surface method is adopted, the saponin content and flavone content in liquorice are used as detection indexes, and an entropy weight method in an R language environment is adopted for weight assignment of the two indexes, a BP neural network and genetic algorithm mathematical model is established, and target optimizing is performed for the extraction technology to obtain an optimal extraction technology. The optimal extraction conditions are as follows: the ammonia concentration is 0.62%, the ethanol concentration is 64%, the reflux time is 1.8h, and the liquid-solid ratio is 12:1. Relative error between the comprehensive evaluation predicted value of the model and the average comprehensive evaluation value of a verification experiment is 1.43%, proving relatively good predictability of the neutral network and genetic algorithm. In the invention, the established mathematical model searching for the optimal extraction conditions for extracting saponin and total flavonoids in liquorice is scientific and feasible, and new reference and idea are provided for optimizing multiple targets of the chemical components and even effective substance basis of traditional Chinese medicine.
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Description

technical field

[0001] The invention relates to an optimized extraction process for simultaneous extraction of saponins and total flavonoids in licorice based on R language. Background technique

[0002] Licorice has been used in traditional medicine for a long time. It is generally the root and rhizome of Glycyrrhizauralensis Fisch., a leguminous plant. After a long period of clinical practice, it has been confirmed that it can relieve cold symptoms, nourish the spleen and Qi, effectively relieve pain, and coordinate various medicines. It can be used to treat symptoms such as colds, spleen and stomach discomfort, weakness and pain in limbs, and can also relieve the toxicity of other medicines. The main components of these medicinal effects are triterpenoids and flavonoids, so these two types of substances are often used as the object of research.

[0003] Glycyrrhizin is the most studied licorice active substance, which belongs to triterpenoids, and glycyrrhizic acid is th...

Claims

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