Multifunctional nanometer hybrid integrated CT imaging and phototherapy and preparing method of multifunctional nanometer hybrid

A nano-hybrid, CT imaging technology, applied in the field of medicine, can solve the problems such as the preparation method and use of multi-functional nano-hybrid, and achieve the effects of good photothermal stability, good water solubility, and easy availability of raw materials
CN106512002AActive Publication Date: 2017-03-22TIANJIN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
TIANJIN UNIV
Publication Date
2017-03-22

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Abstract

The invention discloses a multifunctional nanometer hybrid integrated CT imaging and phototherapy and a preparing method. The nanometer hybrid is shown through MoS2-AuNPs-Ce6, wherein MoS2 is the abbreviation of a molybdenum disulfide nano-plate modified by thiol-polyethylene glycol, AuNPs is the abbreviation of gold nano-particles modified by 2-mercaptopyridine, and Ce6 is the abbreviation of chlorine e6. The preparing technology of the nanometer hybrid MoS2-AuNPs-Ce6 is simple, reaction controllability is high, energy consumption is low, large scale is easy to achieve, raw materials for use are easy to obtain, and the price is low; the nanometer hybrid can be used for CT imaging; good water solubility and good biocompatibility are shown, high near infrared absorption and good photo-thermal stability are achieved, and the hybrid can be used for photo-thermal treatment and infrared thermal imaging at the same time; and a strong photodynamic therapy function is achieved, and an inhibiting function is achieved on tumor cells.
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Description

technical field

[0001] The invention belongs to the field of medicine, and in particular relates to a nano-hybrid compound integrating CT imaging and phototherapy, a preparation method and an application. Background technique

[0002] Photothermal therapy is a minimally invasive tumor treatment technology developed in recent years. It mainly uses near-infrared light to directly irradiate the tumor site with light-absorbing photothermal therapeutic agent to increase the local temperature to kill the tumor. cells, greatly reducing systemic toxicity, so photothermal therapy is seen as one of the very potential alternative techniques for surgical treatment of tumors. Since water and proteins in biological tissues have weak absorption of near-infrared light, an ideal photothermal therapeutic agent should have strong absorption in the near-infrared light region (650-950nm).

[0003] For tumor treatment, there are many limitations in single treatment methods. In order to achieve b...

Claims

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