Water-soluble cinnamic aldehyde slow release inclusion compound and preparation method thereof

A technology of cinnamaldehyde and clathrate is applied in the field of water-soluble cinnamaldehyde sustained-release clathrate and its preparation, which can solve the problems of easy oxidation, insoluble in water, and volatile of cinnamaldehyde, so as to reduce volatility and improve Water-soluble, good application prospects

Inactive Publication Date: 2017-03-29
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In view of this, the object of the present invention is to provide a water-soluble cinnamaldehyde slow-release inclusion compound and its preparation met...

Method used

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  • Water-soluble cinnamic aldehyde slow release inclusion compound and preparation method thereof
  • Water-soluble cinnamic aldehyde slow release inclusion compound and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Weigh 10 mmol of HP-β-CD, dissolve it in 100 ml of deionized water, dissolve 10 mmol of cinnamaldehyde in 10 ml of absolute ethanol, add dropwise to the HP-β-CD aqueous solution, and stir at 50 °C for 5 h, Refrigerate at 4 °C for 12 h and filter through a 45 μm microporous membrane. After the filtrate was freeze-dried, the free cinnamaldehyde was eluted with acetone, dried, crushed and sieved to obtain the clathrate of cinnamaldehyde-HP-β-CD.

Embodiment 2

[0026] Weigh 5 mmol of HP-β-CD, dissolve it in 100 ml of deionized water, dissolve 10 mmol of cinnamaldehyde in 10 ml of absolute ethanol, add dropwise to the HP-β-CD aqueous solution, and stir at 30 °C for 7 h, Refrigerate at 1°C for 16 h and filter through a 45 μm microporous membrane. After the filtrate was freeze-dried, the free cinnamaldehyde was eluted with acetone, dried, crushed and sieved to obtain the clathrate of cinnamaldehyde-HP-β-CD.

Embodiment 3

[0028] Weigh 15 mmol of HP-β-CD, dissolve it in 100 ml of deionized water, dissolve 5 mmol of cinnamaldehyde in 10 ml of absolute ethanol, add it dropwise to the HP-β-CD aqueous solution, and stir at 70 °C for 3 h, Refrigerate at 4 °C for 8 h and filter through a 45 μm microporous membrane. After the filtrate was freeze-dried, the free cinnamaldehyde was eluted with acetone, dried, crushed and sieved to obtain the clathrate of cinnamaldehyde-HP-β-CD.

[0029] From figure 1 It can be seen that: HP-β-CD has a broad and large endothermic peak in the range of 40-115 ℃, and reaches the highest peak at 85-90 ℃, which should be caused by the dehydration of HP-β-CD caused (DSC curve a). Cinnamaldehyde has a broad endothermic peak near 130 °C (DSC curve b). According to its boiling point of 253 °C (atmospheric pressure), this peak is the gasification peak of cinnamaldehyde. When the temperature reaches 220 °C, Cinnamaldehyde is completely vaporized. However, the dehydration peak (4...

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Abstract

The invention discloses a water-soluble cinnamic aldehyde slow release inclusion compound and a preparation method thereof. According to the preparation method, hydroxypropyl-beta-cyclodextrin (HP-beta-CD) is used as a main body molecule, cinnamic aldehyde is used as an object molecule, and ethanol is used as a solubility promoting solvent, so that a water-soluble cinnamic aldehyde supermolecule inclusion compound is made. The method is simple and convenient to operate, low in cost and good in effects. The prepared HP-beta-CD/cinnamic aldehyde inclusion compound is good in water solubility and stable in structure, and the problems that the cinnamic aldehyde is easy to oxidize, easy to volatilize, poor in water-soluble properties and the like existing in various respects of the application of the cinnamic aldehyde are solved to a great extent.

Description

technical field [0001] The invention belongs to the technical field of supramolecular inclusion, relates to a food additive and a preparation method thereof, in particular to a water-soluble cinnamaldehyde slow-release inclusion compound and a preparation method thereof. Background technique [0002] Cinnamaldehyde: Cinnamaldehyde, also known as cinnamaldehyde, is a yellow viscous aldehyde organic compound that exists in large quantities in plants such as cinnamon. Cinnamaldehyde has a strong special smell of cinnamon oil and burnt aroma, and it is used in spices, pharmaceuticals, pesticides, daily fine chemicals, feed, papermaking, food, etc. In addition, cinnamaldehyde is also used in the production of products such as plastics and photosensitive materials. However, cinnamaldehyde has a small molecular weight, is easy to volatilize, is not easy to store, is unstable in strong acidic and strong alkaline media, and is easy to change color, and the unsaturated bonds it conta...

Claims

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Application Information

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IPC IPC(8): A23L3/3499A23L3/3562
Inventor 朱良胡均鹏盛周煌肖凯军
Owner SOUTH CHINA UNIV OF TECH
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