Unlock instant, AI-driven research and patent intelligence for your innovation.

Benzoxazole phenoxy carboxylic acid amide compound and preparation method thereof

The technology of a compound and an acylating agent is applied in the field of benzoxazole phenoxycarboxylic acid amide compounds and the preparation thereof, and can solve the problems of pesticide residues, large dosage, and phytotoxicity of herbicides, and achieves good herbicidal effect, Small dosage and broad herbicidal spectrum

Active Publication Date: 2019-05-14
JIANGSU FUDING CHEM
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Similar to other existing herbicides, paddy field herbicides such as fenpyramid have a large dosage, and are prone to drug resistance and pesticide residues after long-term use. Some herbicides are phytotoxic and require the use of safeners or The shortcomings of other auxiliary materials are not conducive to the large-scale and long-term use of herbicides, so it is necessary to further develop herbicides with better effects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Benzoxazole phenoxy carboxylic acid amide compound and preparation method thereof
  • Benzoxazole phenoxy carboxylic acid amide compound and preparation method thereof
  • Benzoxazole phenoxy carboxylic acid amide compound and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Embodiment 1: the synthesis of compound 1

[0059]

[0060] Add 500g of DMF to a 1000mL four-neck flask, put in 100g of compound A, 113.6g of potassium carbonate and 5g of tetrabutylammonium bromide, raise the temperature to 60°C, add dropwise a mixed solution of 113.5g of compound B in 50g of DMF, and control the temperature at 55-60 ℃, the dropwise addition is completed, and the reaction is about 2 hours. After the reaction is completed, add it to 1000g of water, adjust the pH to 7-8 with hydrochloric acid, stir for 1 hour, filter, and the solid is etherified, and dry it.

[0061] Add 500g of dichloroethane into a 1000ml four-necked bottle, add 100g of compound C, raise the temperature to 50°C, add 42.8g of thionyl chloride dropwise, control the temperature at 50-55°C, finish the dropwise addition, react for 1 hour, and the reaction ends. The acid chloride reaction solution is for use. Add 75g of water, 24.48g of 25% ammonia water, 38.16g of sodium carbonate, and ...

Embodiment 2

[0062] Embodiment 2: the synthesis of compound 2

[0063]

[0064] The acid chloride reaction solution is the same as in Example 1.

[0065] Add 75g of water, 27.95g of 40% monomethylamine aqueous solution, 38.16g of sodium carbonate, and 5g of triethylamine to 1000ml, cool down to 0-5°C, add the acid chloride reaction solution dropwise, control the temperature at 5-10°C, the dropwise addition is completed, and the reaction 1 Hours, the reaction is over, the layers are separated, the organic phase is precipitated, and the crude product is obtained. Add 200g of methanol and heat up to 50°C to dissolve, cool to 5°C, a solid is precipitated, and the product is filtered to obtain a white solid. Yield: 71%, content: 95% .

Embodiment 3

[0066] Embodiment 3: the synthesis of compound 3

[0067]

[0068] The acid chloride reaction solution is the same as in Example 1.

[0069] Add 75g of water, 40.57g of 40% dimethylamine aqueous solution, 38.16g of sodium carbonate, and 5g of triethylamine to 1000ml, cool down to 0-5°C, add the acid chloride reaction solution dropwise, control the temperature at 5-10°C, the dropwise addition is completed, and the reaction 1 Hours, the reaction is over, the layers are separated, the organic phase is precipitated, and the crude product is obtained. Add 200g of methanol and heat up to 50°C to dissolve, cool to 5°C, a solid is precipitated, and the product is filtered to obtain a white solid. Yield: 71%, content: 95% .

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a benzoxazole phenoxy carboxylic acid amide compound and a preparation method thereof. The compound is the compound with structure shown in Formula (E) or its pharmaceutically acceptable salts. The compound or its pharmaceutically acceptable salts can be applied to the weeding of crops, in particular to prevent and remove gramineous weeds, broad-leaved grass or nutgrass flatsedge. The compound is free from any bad influence on normal growth of rice type crops, and needs not safety agent; the dosage is few, the weeding spectrum is wide, and the weeding effect is good; therefore, the compound is more good for agricultural production.

Description

technical field [0001] The invention belongs to the field of pesticides, and in particular relates to a class of benzoxazole phenoxycarboxamide compounds and a preparation method thereof. Background technique [0002] Herbicides refer to agents that can completely or selectively kill weeds, also known as herbicides, and are a class of substances used to eliminate or inhibit plant growth. The development of herbicides in the world is gradually stabilizing, mainly developing varieties with high efficiency, low toxicity, broad spectrum, and low dosage, and disposable treatment agents with little environmental pollution have gradually become the mainstream. The commonly used species are organic compounds, which can be widely used to control harmful plants such as weeds, shrubs, and trees in farmland, orchards, flower nurseries, grasslands and non-cultivated land, railway lines, rivers, reservoirs, warehouses, etc. At present, herbicides commonly used in paddy fields include fen...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07D263/58C07D413/12A01N43/76A01P13/00
CPCA01N43/76C07D263/58C07D413/12
Inventor 刘东卫程李中常青董海龙祝瑞雨古俊坤
Owner JIANGSU FUDING CHEM