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Method and system for the administration of oral care particles

An oral care agent and particle technology, applied in the field of oral care, can solve the problems of not only using jet equipment, limited deposition, etc.

Inactive Publication Date: 2017-05-24
KONINKLJIJKE PHILIPS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, only fluidic devices cannot be used because of the consequent limited deposition of particles in the interproximal area

Method used

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  • Method and system for the administration of oral care particles
  • Method and system for the administration of oral care particles
  • Method and system for the administration of oral care particles

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0063] As an oral care agent, positively charged chitosan gel particles are used, because both the pellicle-coated teeth and mucus have negative surface charges, so the chitosan gel particles are strongly bound to all oral surface. Chitosan gel particles were fabricated by adding 2 m% high viscosity chitosan powder to 50 mM HCl in demineralized water. In addition, as a colorant, 5 m% of titanium dioxide was added to make the particles white. Chitosan was allowed to dissolve for at least 24 h. Subsequently, the 2% chitosan solution was dropped into a 50 mM NaOH solution in demineralized water until a 40 v% chitosan solution (ie, 40 v% of 2% chitosan solution and 60 v% of 50 mM NaOH solution). Allow the drops to gel for at least 30 minutes. The chitosan gel balls were then stirred into small particles using an UltraTurrax mixer at 25000 rpm for 1 min. The gel particles obtained ranged from 20 to 200 microns and the suspension had a pH of 12. A 40 v% chitosan particle suspen...

example 2

[0065] Interproximal transport of particles was tested in an anatomical model of the interproximal space made of black nylon.

[0066] A 0.25 ml glass syringe (Gastight #1725, Hamilton, USA) with a 1.12 mm diameter orifice was positioned with the outlet nozzle against the phantom interproximal space with two clean but moistened adjacent surfaces. Align the syringe parallel to the adjacent surface (0 degree impact angle). The syringe was filled with 0.15 ml of particle suspension and the syringe plunger was pushed with a linear actuator to generate a jet with a total dispense volume of 0.1 ml. The linear actuator is driven pneumatically and the rate is determined by the input gas pressure. Table 1 shows the different jet rate settings tested. Manually very slow speeds (approximately 5 cm / s) were also tested. Jet times were measured using a high-speed camera. After delivering the shots, the samples were removed from the mold and rinsed by soaking in a large beaker of deminer...

example 3

[0072] Example 3 (comparative example)

[0073] A conventional oral irrigator (ie, Philips Air Floss) was used to deliver a 4v% chitosan gel particle suspension similar to Example 2. The current production model of air floss (volume 0.15ml / shot) was used and delivered from both sides (buccal). The jet velocity is higher than 15m / s.

[0074] Figure 4 The results are shown in , again where (a) shows the left surface of an anatomical model of the interproximal space made of black nylon, and (b) indicates the right surface of the anatomical model. As shown, very few particles were deposited inside the interproximal region due to the lack of white spots.

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Abstract

Disclosed is a new method, and a system, for the delivery of particles comprising at least one oral care agent to the oral cavity, so as to particularly enable delivery into the interproximal spaces. The method involves providing a liquid comprising the particles and introducing the liquid into the oral cavity in the form of a fluid jet, said jet having a velocity of from 0.5 m / s to 5m / s. The fluid jet can be generated by an appropriately adapted oral irrigator, but other devices can be used as well. The invention is particularly suitable for the delivery of adhesive gel particles comprising one or more oral care agents, preferably particles for the controlled and / or slow release of such agents.

Description

technical field [0001] The present invention is in the field of oral care and relates to systems and methods for dispensing oral care agents in particulate form. In particular, the invention relates to interproximal delivery of adherent gel particles. Background technique [0002] Oral care agents are often required in the human oral cavity, especially the teeth and gums. Conceivable are, for example, antiplaque agents, antitartar agents, antigingivitis agents, antibacterial agents, and the like. [0003] Such agents are usually dispensed from toothpaste and / or mouth rinses. Because of the typical environment of the oral cavity (eg the presence of saliva), a common problem in the art is that the concentration of active agents from toothpastes and mouthwashes decreases rapidly after their application. Therefore, they do not protect the mouth for a long time, and they therefore need to be applied several times a day. [0004] WO2008 / 135957 discloses a method for cleaning p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61C19/06A61C17/02A61C17/36A61C15/04
CPCA61C15/047A61C17/02A61C17/36A61C19/063A61C15/041
Inventor B·戈藤伯斯A·H·耳麦勒M·K·J·德加格C·格拉斯
Owner KONINKLJIJKE PHILIPS NV
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