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A kind of medicine for preventing and treating fatty liver and obesity and its application in pharmacy

A technology of fatty liver, medicine, applied in the field of medicine

Active Publication Date: 2020-08-18
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the pharmacological effects of borapetoside E in the treatment of fatty liver and obesity

Method used

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  • A kind of medicine for preventing and treating fatty liver and obesity and its application in pharmacy
  • A kind of medicine for preventing and treating fatty liver and obesity and its application in pharmacy
  • A kind of medicine for preventing and treating fatty liver and obesity and its application in pharmacy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The vine was collected in Simao, Yunnan in 2012, with a dry weight of 15 kilograms, crushed, and extracted three times (25 liters each) with 95% ethanol at room temperature for 5 days. The extract was recovered and concentrated under reduced pressure to obtain 1100 g of the extract, which was subjected to silica gel column chromatography and eluted with a petroleum ether / acetone mixed solvent gradient (99:1 to 0:100) to obtain 7 components A-G. Component E (180 g) was then subjected to silica gel column chromatography and eluted with a chloroform / methanol mixed solvent gradient (40:1 to 5:1) to obtain three components E1-E3. Component E1 was repeatedly chromatographed through a Sephadex LH-20 column and eluted with methanol to obtain 5.3 g of pure compound borapetoside E. The identification of the compound structure is determined by the comparison and analysis of spectral data.

[0026] 1. The effect of Borapetoside E on fatty liver in mice induced by high-fat and high-su...

Embodiment 2

[0042] Preparation of injection preparations:

[0043] According to the method of Example 1, first obtain 50 mg of borapetoside E of the present invention, dissolve it in 2 ml of propylene glycol, and fill the filtered solution into an ampoule under aseptic conditions.

Embodiment 3

[0045] Preparation of powder:

[0046] According to the method of Example 1, the compound borapetoside E of the present invention was first obtained, and the excipient was added in a ratio of 9:1 by weight to the excipient to prepare a powder.

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Abstract

The invention relates to new application of borapetoside E in preparing drugs for preventing and treating metabolic diseases of fatty liver, obesity and the like. A research discovers that a compound borapetoside E of which the dosage is40 mg / kg is capable of obviously reducing the level of triglyceride, cholesterol and free fatty acid in livers of HFGD (High Fat and Glucose Diet) induced mice; the obesity symptom of the HFGD induced mice is remarkably relieved, and energy metabolism of the HFGD induced mice is promoted; the action mechanism can be related to SREBP (Sterol Regulatory Element Binding Proteins) inhibition. The curative effect of the compound borapetoside E under the dosage is superior to that of 200mg / kg of metformin, and the compound borapetoside E can be used for preparing the drugs, healthcare products and functional food for preventing and treating the fatty liver and the obesity.

Description

Technical field: [0001] The invention belongs to the technical field of medicine, and specifically relates to a new application of the compound borapetoside E and a pharmaceutical composition using the compound as an active ingredient in the preparation of drugs for preventing and treating fatty liver and obesity. [0002] technical background: [0003] In 2008, the World Health Organization estimated that there were 1.4 billion overweight adults, of which 500 million were obese. By 2030, the number of obese patients will reach 1 billion. Obesity is the main cause of metabolic diseases such as fatty liver, type 2 diabetes, cardiovascular disease and hypertension. These diseases seriously affect people's quality of life and cause a lot of medical expenses. Recent studies have found that Sterol regulatory element binding proteins transcription factors (SREBPs) have an important effect on maintaining the body's energy metabolism balance. SREBP mainly includes two families, SREPB-1 an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/365A61P1/16A61P3/04A61P3/00A23L33/10
CPCA23V2002/00A61K31/365A23V2200/30A23V2200/332
Inventor 刘吉开熊文勇许宇辉逯艳婷王芳
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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