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Preparation method and application of avermectin derivative and application thereof

A technology of abamectin and derivatives, applied in the preparation of sugar derivatives, botany equipment and methods, sugar derivatives, etc.

Inactive Publication Date: 2017-07-04
GUANGXI ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] But so far, there is no report of obtaining a natural compound with the activity of inhibiting sugarcane smut from the secondary metabolites of marine organisms, and there is no use of abamectin derivatives for inhibiting sugarcane smut reports in

Method used

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  • Preparation method and application of avermectin derivative and application thereof
  • Preparation method and application of avermectin derivative and application thereof
  • Preparation method and application of avermectin derivative and application thereof

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Embodiment Construction

[0017] One, Abamectin derivative B of the present invention 1c preparation of

[0018] Fresh gorgonian coral (Anthogorgia caerulea) samples were chopped and soaked in ethanol→dichloromethane→ethanol in turn at room temperature, and concentrated in a vacuum (0.09MPa, 43°C) to obtain a concentrated extract. The gorgonian concentrated extract is extracted with an equal volume of petroleum ether, and the extraction is repeated until the petroleum ether phase is colorless. The petroleum ether phase was discarded, and the residual phase was repeatedly extracted with an equal volume of ethyl acetate, and the resulting ethyl acetate phases were combined and concentrated in vacuo to obtain the ethyl acetate phase extract.

[0019] Mix the ethyl acetate extract with silica gel powder evenly, grind it into powder after drying, and put it into a normal phase silica gel column by wet packing (silica gel powder is 200-300 mesh, packing solvent: CHCl 3 ), using CHCl 3 -Me 2 CO system (CH...

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Abstract

The invention discloses an avermectin derivative, which is extracted and separated from Anthogorgia caerulea, and is named as 5-O-dimethyl-25-bis(1-methylpropyl)-25-(1-methylbutyl)avermectin Ala. Tests indicate that the EC50 value of the avermectin derivative Blc on ustilago scitaminea MAT-1 and MAT-2 matching basidiospore proliferation is far less than a positive control azoxystrobin suspending agent, and has good avermectin derivative inhibition activity. The compound Blc is a marine natural active component, also is easily soluble in methanol and ethanol, and has good alcohol affinity, thus being applicable individually or in combination to preparation of efficient biopesticides for control of sugarcane ustilago. The invention provides a new use for development of avermectin derivatives, and provides a new source for preparation of novel pesticides inhibiting ustilago scitaminea.

Description

technical field [0001] The invention belongs to the field of biopesticides, and in particular relates to a preparation method and application of abamectin derivatives, in particular to a method for inhibiting sugarcane smut by a natural abamectin derivative derived from Gorgoniana floridae application. Background technique [0002] Sugarcane smut, caused by the fungus Sporisorium scitamineum, is one of the most troublesome and devastating sugarcane diseases in the world. The disease spreads worldwide, and the fungal disease has been reported from almost every country that grows sugar cane. Varieties infected with sugarcane smut can cause significant losses in sugarcane yield and sugar content. Drought ecological conditions are more conducive to the spread of teliospores of sugarcane smut, and more than 90% of sugarcane in China is planted in dry land or dry slope land. Susceptible sugarcane varieties account for more than 50% of the total sugarcane planting area, causing ...

Claims

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Application Information

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IPC IPC(8): A01N43/90A01P3/00C07H17/08C07H1/08
CPCA01N43/90C07H1/08C07H17/08
Inventor 高程海余练李菲苏志维何小英
Owner GUANGXI ACAD OF SCI
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