Macrolide derivatives and their preparation methods and applications

A kind of macrolide and derivative technology, applied in the application of inhibiting sugarcane black ear mold, macrolide derivative and preparation thereof, twenty-four-membered macrolide derivative and preparation field thereof , which can solve problems such as human health hazards and environmental pollution

Active Publication Date: 2020-05-19
GUANGXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chemical pesticides have been proven to be an effective means of preventing and controlling sugarcane smut. However, the widespread use of artificially synthesized chemical pesticides not only causes serious pollution to the environment, but also causes harm to human health.

Method used

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  • Macrolide derivatives and their preparation methods and applications
  • Macrolide derivatives and their preparation methods and applications
  • Macrolide derivatives and their preparation methods and applications

Examples

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Embodiment Construction

[0018] One, the preparation of macrolide derivatives of the present invention

[0019] Pick a small amount of gorgonian endophytic bacillus of rice grain size from the plate and insert it into the liquid medium (the formula is 2.0g / L glucose, 2.0g / L yeast extract, 2.0g / L malt extract, salinity 1.022), in Shake culture at 140 rpm at 28°C for 10 days to obtain 200 L of fermentation broth.

[0020] The fermentation broth was ultrasonically crushed and then extracted with ethyl acetate, the ethyl acetate phases were combined, and concentrated in vacuo to obtain 51.22 g of concentrated fermented extract. The ethyl acetate concentrated extract is packed into a normal phase silica gel column by wet packing (column packing solvent: CHCl 3 ), using CHCl 3 -Me 2 CO system (volume ratio CHCl 3 : Me 2 CO=1:0.1, 1:0.2, 1:0.4, 1:0.8) and CHCl 3 -MeOH system (volume ratio CHCl 3 : MeOH=1:0.1, 1:0.2, 1:0.35, 0:1) sequential gradient elution, a total of 117 fractions were collected, and...

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Abstract

The invention discloses a macrolide derivative, which is extracted and separated from the fermentation broth of Bacillus methylotrophicus, belongs to a 24-membered macrolide derivative, and is named as 3,5,9,11,17,19-hexaene-2-ketone,8,14,16,21-tetrahydroxy-24-ethyl 24-membered ring lactone. According to the present invention, the test results show that the EC50 value of the 24-membered macrolide derivative M1 on the teliospore germination of Ustilago scitaminea Sydow is far lower than the EC50 value of the positive control reagent difenoconazole emulsifiable concentrate on the teliospore germination of Ustilago scitaminea Sydow, such that the compound M1 has good Ustilago scitaminea Sydow inhibition activity; and the compound M1 is the marine natural active component, can be subjected to large-scale fermentation extraction, it is easily soluble in methanol and ethanol, and has good alcohol affinity, such that the compound M1 can be used for preparing the efficient sugar cane culmicolous smut prevention and control biological pesticide in a separate or combination manner.

Description

technical field [0001] The invention belongs to the field of biopesticides, and in particular relates to a macrolide derivative and its preparation method and application, in particular to a 24-membered macrolide derivative and its preparation method and its ability to inhibit sugarcane smut Application to fungi. Background technique [0002] The world's growing demand for sugar and sugarcane ethanol continues to drive the development of sugarcane agriculture. During growth, sugarcane crops are sensitive to a variety of biotic and abiotic factors, including sugarcane smut. The disease significantly reduces sugarcane length and girth, number of internodes, moisture content and stem weight, causing major losses in sugarcane yield and sugar content. Sugarcane smut spreads worldwide, covering most of the sugarcane producing areas, causing severe yield losses and is one of the most serious constraints on global sugarcane production. Chemical pesticides have been proved to be a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D313/00C12P17/08A01N43/22A01P3/00C12R1/07
CPCA01N43/22C07D313/00C12P17/08
Inventor 余炼张学洪颜栋美李小群
Owner GUANGXI UNIV
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