Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method and application of avermectin derivative

A kind of technology of avermectin and derivatives, applied in the directions of sugar derivatives preparation, sugar derivatives, sugar derivatives and the like

Inactive Publication Date: 2017-06-27
GUANGXI ACAD OF SCI
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have been no reports of applying abamectin derivatives obtained from secondary metabolites of marine organisms to marine antifouling paints

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method and application of avermectin derivative
  • Preparation method and application of avermectin derivative
  • Preparation method and application of avermectin derivative

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0019] One, Abamectin derivative B of the present invention 1e preparation of

[0020] Fresh gorgonian coral (Anthogorgia caerulea) samples (wet weight about 5.0kg) were shredded and then soaked in ethanol and dichloromethane at room temperature, and then vacuum concentrated (0.09MPa, 43°C) to obtain a concentrated extract. The gorgonian concentrated extract is extracted with an equal volume of petroleum ether, and the extraction is repeated until the petroleum ether phase is colorless. The petroleum ether phase was discarded, the residual phase was first extracted with an equal volume of ethyl acetate, the obtained ethyl acetate phases were combined, and concentrated under reduced pressure to obtain 24.82 g of the ethyl acetate phase extract.

[0021] Mix 24.82g of ethyl acetate extract with silica gel powder evenly, put it into a normal phase silica gel column by wet packing, and use CHCl 3 -Me 2 CO system (CHCl 3 : Me 2 CO=1:0.1, 1:0.2, 1:0.4, 1:0.8 / V:V) Gradient eluti...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an avermectin derivative which is obtained by extracting and separating Anthogorgia caerulea and is named as 5-O-dimethyl-25-bis-(1-methyl propyl)-25-[(1S)-1,4-dimethyl amyl] abamectin Ala. The test shows that the EC50 value of the avermectin derivative B1e to resist adhering of typical marine fouling organism barnacle (0.12+-0.02 mu g / mL) is far smaller than the positive control butenolide (4.37+-1.22 mu g / mL), and the derivative has excellent activity to resist the typical marine fouling organism barnacle. The compound Ble is a marine natural active ingredient, is easily soluble in methanol and ethanol and has excellent alcohol-philicity, so that the avermectin derivative can be used separately or combined for preparing efficient marine anti-fouling paint. A new application is developed for the avermectin derivative, and a new source is provided for preparing the novel marine anti-fouling paint.

Description

technical field [0001] The invention belongs to the field of marine environmental protection and antifouling, and in particular relates to a preparation method and application of abamectin derivatives, in particular to a natural abamectin derivative derived from Gorgoniana genus in marine antifouling paints Applications. Background technique [0002] The attachment and accumulation of marine fouling organisms limit people's development and utilization of marine resources, such as accelerating the corrosion of metals, affecting the normal use of marine infrastructure, and causing serious damage to industries such as shipping, aquaculture, coastal defense, and coastal power plants. Technical and operational troubles. Biofouling is a serious global problem in marine ecosystems, resulting in increased material and economic costs worldwide. Commonly used chemical means to prevent the accumulation of fouling organic matter, such as various toxic substances (organotin compounds) ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07H17/08C07H1/08C09D5/16
CPCC07H1/08C07H17/08C09D5/1625
Inventor 高程海余练李菲何碧娟江蕾李家怡
Owner GUANGXI ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com