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Secoiridoid glycoside compound

A technology of iridoid glycosides and compounds, which is applied in the field of terpene glycosides and can solve problems such as wide application mismatch

Pending Publication Date: 2022-04-12
GUANGXI UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The curative effect of yellow-red diamond is definite, but there are few domestic and foreign literature reports on the chemical composition of yellow-red diamond, which does not match its wide application in Yao nationality areas

Method used

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  • Secoiridoid glycoside compound
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Examples

Experimental program
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Effect test

Embodiment Construction

[0013] Study on Calcular Aliefalipocylanside Compounds in Yao Medicine Huanghong Diamond

[0014] (1) Preparation

[0015] The yellow red drill medicine was powdered with a pulverizer, and the dry yellow red drill medicine is 3kg, and in a 20L round bottom flask, extract 4 h, filtrate, combined filtrate, at temperature with 70% methanol (4 × 6L). 55 ° C was refluxed and refluxed to obtain a yellow breeha diamond extract (180 g).

[0016] Take the yellow red diamond dipper 150g, followed by silica gel (300 mesh), after the mixture is separated, the column is separated, with a dichloromethane-methanol solvent system (20: 1, 15: 1, 10: 1, 5) : 1, 1: 1, 0: 1 / v: V) Perform gradient elution, TLC spots were combined, and 6 flow divided (FR.1 ~ 6) was concentrated under reduced pressure.

[0017] FR.1 was eluted with MCI column to elute with methanol-water (10% to 100%), resulting in FR.1.10% ~ 100%, Fr.1.70% (100 mg) by analyzing semi-prepared high-performance liquid chromatography Elu...

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Abstract

The invention discloses a split-ring iridoid glycoside compound, the chemical formula of the split-ring iridoid glycoside compound is C34H40O17, the general name of the split-ring iridoid glycoside compound is 10-(3, 5-dimethoxy-4-hydroxybenzoate)-iridoid glycoside, and the split-ring iridoid glycoside compound belongs to a natural active component, is easy to dissolve in methanol and ethanol, and has good alcohol affinity. Accordingly, the inventor also establishes a corresponding preparation method for extracting and separating the compound. Experimental research shows that the compound can effectively inhibit release of RAW264.7 cell NO, has a certain anti-inflammatory effect and has no toxic effect on cells. According to the invention, intentional exploration is carried out on medicinal research of the Yao-nationality medicine, namely, the kadsura coccinea and the secoiridoid glycoside compounds thereof, and a scientific basis is also provided for further development of related medicines.

Description

Technical field [0001] The present invention belongs to the field of terpenoid compounds, and more particularly to a cracked cycloolein etheriparide compound. Background technique [0002] Yao classics use the yellow buddhism (Wiang Hongh Nzunx, alknar green bamboo vine, gallbladder, bronze wind) is the upper part of the Jasminum Pentaneurum Hand.-Mazz, mainly distributed in Guangxi, Guangdong, Hainan, It belongs to one of the "18th Drills" of Yao Medicine. Huang Hong drilled with a wind and wind, and the effect of scattered and pain relief, spleen and swelling, Yao people used in rheumatism, rheumatoid joints, bumbles, stomach pain, postpartial abdominal pain, weak edema. Huang Hong drilled therapeutic effect, but there were few reports on domestic and foreign literature on Huanghong drilling chemical composition, which is not matched with its wide application in the Yao area. Inventive content [0003] The technical problem to be solved by the present invention is to provide a...

Claims

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Application Information

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IPC IPC(8): C07H17/04C07H1/08A61P29/00
Inventor 韦玮邓家刚侯小涛郝二伟张萌张帆
Owner GUANGXI UNIV OF CHINESE MEDICINE
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