38results about How to "Good anti-aging activity" patented technology

Personal care products including cosmetics, grooming products and topical pharmaceutical products can be produced including a polypeptide of between 3 and 12 amino acids in length and a ceramide. These formulations are particularly useful in addressing wrinkles in human subjects and in particular facial skin and hands. Certain analogs and derivatives of these polypeptides may be used in these formulations and/or alone. Methods of using these formulations are also disclosed.

The invention discloses a rose health beverage having efficacy for delaying senility. The rose health beverage is prepared by scientific compatibility of rose and other Chinese herbal medicine raw materials. Preferably, the rose health beverage is prepared from the raw materials in parts by mass: 20-30 parts of rose, 20-30 parts of wolfberry, 5-10 parts of dendrobium nobile, 5-10 parts of dioscorea rhizome, 2-5 parts of liquorice, 10-15 parts of white atractylodes rhizome, 3-5 parts of eleutherococcus senticosus, 3-5 parts of prepared rehmannia root, 2-3 parts of pseudo-ginseng, 3-5 parts of rhodiola rosea and 3-5 parts of stevia rebaudiana, and is prepared through the processes of enzymolysis, extraction, mixing, blending, filling and sterilization. The rose health beverage has the advantages that through synergistic effect of the rose, the wolfberry and other Chinese herbal medicines, the rose health beverage has the remarkable effects of resisting senility, tonifying qi and benefiting body, supporting the healthy energy, resisting fatigue, increasing immunnity, prolonging life and the like, is safe without side effect, is convenient to eat, and has relatively good market application prospects.

The invention discloses an astaxanthin health beverage with ageing delaying efficacy. The beverage is obtained through scientific compatibility of astaxanthin and Chinese herbal medicine, and preferably contains 10-20 parts of astaxanthin, 15-20 parts of wolfberry fruit, 10-15 parts of hawthorn fruit, 10-20 parts of Radix Codonopsis, 5-10 parts of Polygonum multiflorum, 10-15 parts of Rhizoma Atractylodis Macrocephalae, 5-8 parts of Ligusticum wallichii, 3-5 parts of panax notoginseng, 3-5 parts of Radix Puerariae, 4-6 parts of unprepared rehmannia root, 2-3 parts of Chinese angelica, 3-5 parts of licorice root and 3-5 parts of Stevia Rebaudiana Bertoni. The beverage is prepared through a technology comprising the steps of extraction, mixing, blending, and loading sterilization. The beverage has synergism between astaxanthin and Chinese herbal medicines, has substantial efficacies of preventing ageing, invigorating qi and tonifying, supporting healthy energy and consolidating body resistance, preventing fatigue and prolonging life, and has the advantages of safety, no side effects, convenient eating and good market application prospect.

The invention provides a cucuribitane triterpene compound 1-11 and an extraction method thereof. The extraction method comprises the following steps: grinding bitter gourd fruit into a powder, puttingthe powder into methyl alcohol for extracting, extracting an extract with ethyl acetate and water so as to obtain crude extracts of a water layer and an ester layer; carrying out separation purification on the crude extracts respectively so as to obtain the compound 1-11. The extraction method provided by the invention is simple and practicable in operation and high in yield. According to the cucuribitane triterpene compound provided by the invention, in an anti-aging in vitro screening model, the replicability service lives of yeast cells are obviously prolonged. The compound can be appliedto preparing anti-aging medicines and health products. A basis is provided for research and development and basic research of anti-aging new drugs, and the compound has an important practical significance. The structural formula of the cucuribitane triterpene compound is as shown in the description.

The present invention discloses an aging delaying abalone and sea cucumber complex liquid which is scientifically matched by the raw materials of abalones, sea cucumbers and Chinese herbal medicines, and the optimized formula is as follows: 20-30 parts of sea cucumbers, 20-30 parts of abalones, 5-10 parts of astragalus membranaceus, 5-10 parts of Chinese wolfberry fruits, 2-5 parts of codonopsis pilosula, 10-15 parts of rhodiola rosea, 3-5 parts of cornus officinalis, 3-5 parts of hippophae rhamnoides, 2-3 parts of fallopia multiflora, 3-5 parts of medicated leaven and 3-5 parts of stevia rebaudiana. The abalone and sea cucumber complex liquid is prepared by the following processes: enzymatic hydrolyzing, extracting, mixing, blending, filling and sterilizing. The complex liquid has the advantage that by the synergistic effects of abalones, sea cucumbers and Chinese herbal medicines, the complex liquid has significant effects of preventing aging, supplementing and tonifying qi, supporting vital qi and consolidating constitution, preventing fatigue, prolonging life, etc., is safe and has no side effects, is convenient to eat, and has better market prospects.

The invention provides a novel nutrient-enriched vital wheat gluten product for difficulties of an existing vital wheat gluten product in meeting requirements of a user on healthcare effects and shortcomings of related technologies. The healthcare requirements are met, the application space of vital wheat gluten is expanded, and the economic benefits of the wheat deep processing industry are improved. The vital wheat gluten, vital wheat gluten peptides, adlay seed powder, traditional Chinese herbal extract powder, spirulina powder and seaweed polysaccharides are scientifically proportioned, so that the original physiochemical properties of the vital wheat gluten are ensured, the nutritional functionality of the vital wheat gluten product is remarkably improved, and the vital wheat gluten product is endowed with the effects of resisting fatigue, invigorating qi, strengthening and consolidating body resistance, resisting aging, prolonging life and the like. Traditional Chinese herbs such as lycii fructus, puerariae lobatae radix, fiveleaf gynostemma herb, rhodiolae crenulatae radix et rhizoma, glycyrrhizae radix et rhizoma, polygoni multiflori radix, astragali radix, epimedii folium, acanthopanacis senticosi radix et rhizoma seu caulis, atractylodis macrocephalae rhizoma, astragali radix, schisandrae chinensis fructus, eucommiae cortex, houtttuyniae herba and ginseng radix et rhizoma are scientifically proportioned, and the nutritional healthcare functionality of the product is further improved by a preparation process comprising ultrasonic-assisted enzymolysis, mixed fermentation and decoction with water.

The present invention relates to a new use of panduratin derivatives or a Kaempferia pandurata extract comprising the same. More particularly, the present invention relates to a composition for improving wrinkles and/or preventing aging, which comprises a panduratin derivative or a Kaempferia pandurata extract comprising the same. The said the panduratin derivative or the Kaempferia pandurata extract comprising the same induces cell proliferation, inhibits degradation of collagen, and promotes synthesis of collagen, therefore, it shows excellent activity in prevention of aging, particularly preventing, improving or treating wrinkle and it can be used as an effective ingredient in a cosmetic, food or pharmaceutical composition.

The invention discloses a holothurian-scallop healthcare drink with an aging delaying function. The holothurian-scallop healthcare drink with the aging delaying function is prepared from holothurian, dried scallops and Chinese medicinal herbal raw materials by scientific compatibility, through a preferred formula comprising 20 to 30 parts of the dried scallops, 20 to 30 parts of the holothurian, 5 to 10 parts of radix polygoni multiflori, 5 to 10 parts of rhiizoma dioscoreae, 2 to 5 parts of liquorice, 10 to 15 parts of herba cistanche, 3 to 5 parts of acanthopanax, 3 to 5 parts of radix astragali, 2 to 3 parts of pseudo-ginseng, 3 to 5 parts of radix puerariae, and 3 to 5 parts of stevia rebaudiana bertoni, and afterwards, according to a process of enzymolysis, extraction, mixing, preparation, filling and sterilization. The holothurian-scallop healthcare drink with the aging delaying function has the advantages of having obvious functions of anti-aging, Qi tonifying and invigoration, healthy energy supporting, anti-fatigue, life prolonging and the like through synergistic effects among the holothurian, the dried scallops and Chinese medicinal herbs, is safe, has no side effects, is convenient to take, and has a better market application prospect.

The invention discloses astaxanthin composite fixed liquor with a senescence delaying function. The astaxanthin composite fixed liquor is prepared from astaxanthin and Chinese herbal medicine raw materials through scientific compatibility and preferably comprises, by weight, 10-20 parts of astaxanthin, 15-20 parts of medlar, 10-15 parts of mulberries, 10-20 parts of astragalus membranaceus, 5-10 parts of codonopsis pilosula, 10-15 parts of radix paeoniae alba, 5-8 parts of lucid ganoderma, 3-5 parts of pseudo-ginseng, 3-5 parts of radix puerariae, 4-6 parts of gynostemma pentaphylla, 2-3 parts of angelica sinensis, 3-5 parts of liquorice and 3-5 parts of stevia rebaudiana, and the astaxanthin composite fixed liquor is prepared through the technologies of leaching, extracting, mixing, blending, filling and sterilizing. The astaxanthin composite fixed liquor has the advantages of having remarkable functions of delaying senescence, tonifying qi and the body, supporting the healthy energy, resisting fatigue, prolonging life and the like by means of the synergistic effect among the astaxanthin and Chinese herbal medicines and being safe, free from side effects and convenient to eat and has good market application prospects.

The invention relates to a medicine or a cosmetic prepared from fibroblast extracellular vesicles. The effect of the invention is achieved by inhibiting P53 activity to improve fibroblast activity and prevent aging to produce ectovesicles at high yield. A monoclonal antibody is used for inhibiting the activity of P53, after the monoclonal antibody is added into a culture medium of fibroblasts, the aging of the fibroblasts can be inhibited, the content of exovesicles secreted by the fibroblasts can be increased, and the exovesicles are good in anti-aging activity and suitable for preparing anti-aging beautifying or medicine products. Good market application values are realized.

The invention provides a method for quickly screening saccharification and/or ageing resisting substances. The method comprises the steps of feeding fruit flies of 1-3 days old with a cane sugar aqueous solution containing potential active substances to be tested, besides, using the fruit flies only fed with a cane sugar aqueous solution as a control group, then performing hungry treatment on thetwo groups of the fruit flies, finally, performing feeding with pyruvic aldehyde, and counting the death quantity of the fruit flies at intervals until the two groups of the fruit flies are dead completely; and when the mortality rate of the fruit flies in the control group is 40%-60%, performing statistics on the survival condition of the fruit flies in the experiment group, judging whether the potential active substances to be tested can prolong the survival time of the fruit flies or not, and if yes, determining that the substances are saccharification and/or ageing resisting substances. Within a 7-day experiment period, compared with a conventional cell model and other animal models, at an extremely low economy cost, whether one substance has activity of resisting saccharification andageing can be determined, and a prominent platform is provided for large-scale high-throughput screening of active substances for resisting diabetes and resisting ageing relevant diseases.

The invention discloses a croton acylated catapol derivative which is prepared by esterifying catalpol and crotonic anhydride. The invention provides a corresponding preparation method and application, and the preparation method comprises the following steps: 1) dissolving catalpol into triethylamine, adding a catalyst 4-dimethylaminopyridine, adding crotonic anhydride under protection of nitrogengas, reacting for 12-36 hours at a temperature of 30-90 DEG C, and drying triethylamine by distilling to obtain a product, wherein a molar ratio of crotonic anhydride to catalpol is (6-18) to 1, anda molar ratio of 4-dimethylaminopyridine to catalpol is 1 to (9.5-10.5); and 2) dissolving the product in the step 1) into dichloromethane, adding an alkaline agent, standing and layering, discardingan upper-layer water phase, drying an organic phase to remove water, drying dichloromethane by distilling, purifying and separating, evaporating-drying, and filtering to obtain the catapol derivative.The catapol derivative has good anti-ageing activity, improves blood-brain barrier permeability of catapol, and has an esterification rate of 99.16%.

The invention discloses a health astaxanthin capsule with an effect of delaying senility. The health astaxanthin capsule is scientifically mixed by astaxanthin and traditional Chinese herbal raw materials, preferably consists of 20-30 parts of astaxanthin, 20-30 parts of fruits of wolfberry, 5-10 parts of astragalus membranaceus, 5-10 parts of pseudo-ginseng, 2-5 parts of codonopsis pilosula, 10-15 parts of liquorice, 3-5 parts of dandelion, 3-5 parts of radix polygonati officinalis, 2-3 parts of polygonum multiflorum, 3-5 parts of radix ophiopogonis and 3-5 parts of stevia rebaudiana, and is prepared by blending, mixing, sterilization and capsule canning technologies. The health astaxanthin capsule has the advantages that the product has obvious effects of resisting senility, tonifying qi, nourishing, supporting the healthy energy, resisting fatigue, prolonging the life and the like under the synergistic action between astaxanthin and traditional Chinese herbs, is safe and convenient to eat, does not have side effects and has a good market application prospect.

The invention provides cell anti-aging essence and a preparation method thereof. The cell anti-aging essence is prepared from the following components in parts by weight: 1 to 5 parts of dandelion extract, 1 to 5 parts of liquorice overground part extract, 1 to 5 parts of boxthorn leaf extract, 1 to 5 parts of spirulina extract, 1 to 5 parts of grape seed extract, 1 to 5 parts of cyclo-baicaleol and 80 to 100 parts of solvent. The degreased grape seed powder is extracted by using the ethanol alkali solution, so that the absorbability of the grape seed extract is improved, and the anti-aging activity is improved; the anti-aging composition has the advantages that the anti-aging effect is good, the anti-aging effect is good, the plant extract and the cyclo-baicaleol are matched, the content of lipid peroxidation product malondialdehyde (MDA) generated by oxidative stress in a mouse body can be obviously reduced, secretion of TNF-alpha, IL-6 and IL-1beta in rat serum caused by D-Gal is reduced, and the anti-aging performance is synergistically enhanced. The cell anti-aging essence is wide in application range and can be applied to skin care products, and the anti-aging performance is improved.

The invention relates to application of umbilical cord stem cells in preparation of anti-aging drugs and related beauty products. The invention provides a polypeptide for inhibiting the aging of umbilical cord blood stem cells, which can effectively inhibit the aging of umbilical cord blood stem cells. The umbilical cord blood stem cells cultured by the polypeptide are proved to have better anti-aging activity and skin moisture content improving effect than umbilical cord blood stem cells cultured without the polypeptide in an animal model, and the umbilical cord blood stem cells cultured by the polypeptide have very good application value.

The invention relates to the field of proteins, in particular to bioactive polypeptide QPEVMGVSKVKEAMAPKQKEMPFPKY as well as preparation and application thereof. The amino acid sequence of the bioactive polypeptide QPEVMGVSKVKEAMAPKQKEMPFPKY is Gln-Pro-Glu-Val-Met-Gly-Val-Ser-Lys-ValLys-Glu-Ala-Met-Ala-Pro-Lys-Gln-Lys-GluMet-Pro-Phe-Pro-Lys-Tyr. In-vitro antioxidant experiments and in-vivo antiaging experiments prove that the polypeptide QPEVMGVSKVKEAMAPKQKEMPFPKY has better antioxidant bioactivity and antiaging activity; on one hand, the polypeptide QPEVMGVSKVKEAMAPKQKEMPFPKY has better antioxidant activity and can scavenge free radicals in the organism and improve quality of life; on the other hand, the activity of in-vivo anti-peroxidase system can be improved, the function of the organism for resisting exogenous stimulation is enhanced, the probability of aging, senility and illness of the organism is reduced, and the bioactive polypeptide has great significance in development of food, health care products and drugs with antioxidant and antiaging functions.

The invention discloses a preparation method and application of fructozine, and the preparation method of the fructozine comprises the steps of synthesis of 1-dibenzylamino -1-deoxidized- D-fructose, preparation of 1-dibenzylamino- 1-deoxidized -4, 5-oxo- isopropylidene- D-fructose, preparation of isopropylidene protected fructozine and synthesis of the fructozine. According to the preparation method of the fructosazine, Pd/C is used for catalyzing amino sugar to be oxidized to form pyrazine rings for the first time. According to the reaction route, raw materials are economical and easy to obtain, reaction conditions are mild, high temperature and high pressure are avoided, the product is single and high in purity, and a complex post-treatment process is avoided. In addition, the invention provides application of the fructosazine in preparation of anti-aging cosmetics.

The invention relates to the field of proteins, in particular to bioactive polypeptide KEPMIGVNQELA as well as a preparation method and an application thereof. The amino acid sequence of the bioactivepolypeptide KEPMIGVNQELA is LysGlu-Pro-Met-Ile-Gly-Val-Asn-Gln-Glu-LeuAla. In-vitro antioxidant experiments and in-vivo antiaging experiments prove that the polypeptide KEPMIGVNQELA has better antioxidant bioactivity and antiaging activity; on one hand, the bioactive polypeptide KEPMIGVNQELA has better antioxidant activity and can scavenge free radicals in the organism, and quality of life is improved; on the other hand, activity of an in-vivo peroxidase-resistant system can be improved, resistance of the organism to exogenous stimulation is enhanced, so that probabilities of aging and sickness of the organism are reduced, and the polypeptide has great significance in developing food, health care products and drugs with antioxidant and antiaging functions.

The invention discloses an ocean health capsule with effects of delaying senility. The ocean health capsule is scientifically mixed by astaxanthin and traditional Chinese herbal raw materials, preferably consists of 20-30 parts of astaxanthin, 20-30 parts of chitosan, 5-10 parts of astragalus membranaceus, 5-10 parts of fruits of wolfberry, 2-5 parts of codonopsis pilosula, 10-15 parts of rhodiola rosea, 3-5 parts of dogwood, 3-5 parts of sea-buckthorn, 2-3 parts of polygonum multiflorum, 3-5 parts of medicated leaven and 3-5 parts of stevia rebaudiana, and is prepared by blending, mixing, sterilization and capsule canning technologies. The ocean health capsule has the advantages that the product has obvious effects of resisting senility, tonifying qi, nourishing, supporting the healthy energy, resisting fatigue, prolonging the life and the like under the synergistic action among chitosan, astaxanthin and traditional Chinese herbs, is safe and convenient to eat, does not have side effects and has a good market application prospect.

The invention discloses a sea cucumber and dried scallop compound wine with an effect of delaying senescence. The sea cucumber and dried scallop compound wine with the effect of delaying senescence comprises sea cucumbers, dried scallops and Chinese herbal medicine raw materials which are compatible scientifically, preferably comprises the following raw materials in part by weight: 20-30 parts of dried scallops, 20-30 parts of sea cucumbers, 5-10 parts of polygonum multiflorum, 5-10 parts of wolfberries, 2-5 parts of ginseng, 10-15 parts of rhodiola rosea, 3-5 parts of manyprickle acanthopanax roots, 3-5 parts of astragalus membranaceus, 2-3 parts of pseudo-ginseng, 3-5 parts of gynostemma pentaphylla and 3-5 parts of stevia rebaudiana and is technologically prepared by the following procedures of enzymolysis, extraction, mixing, blending, filling and sterilizing. The sea cucumber and dried scallop compound wine with the effect of delaying senescence has the advantages that by a synergistic effect of the sea cucumbers, the dried scallops and the Chinese herbal medicines, the sea cucumber and dried scallop compound wine has obvious effects of resisting ageing, tonifying qi, strengthening and consolidating body resistance, resisting fatigue and prolonging life, is safe, does not have side effects, is convenient to drink and has a good market application prospect.

The invention discloses an anti-aging secretory Klotho protein and a coding gene thereof, a recombinant expression vector and an application. The recombinant anti-aging protein expressed by a prokaryotic expression vector is screened by adopting a genetic engineering technology and strategy, adopting high-fidelity Taq polymerase, optimizing a codon sequence of a target gene and adding a histidinetag, and the amino acid sequence of the recombinant anti-aging protein is shown as SEQ ID NO.1. The invention also provides a gene for coding the anti-aging secretory Klotho protein, and the sequenceof the gene is shown as SEQ ID NO.2. The obtained Klotho protein has a better anti-aging function, and can be used for resisting aging, regulating the generation of nitric oxide, resisting oxidative stress, regulating calcium and phosphorus metabolism, resisting inflammation, inhibiting cancer and the like.