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Application of single nucleotide polymorphism (SNP) rs7576984 and rs2066802 in detecting tuberculosis susceptibility

A single nucleotide polymorphism and nucleotide technology, which is applied to the application of single nucleotide polymorphism rs7576984 and rs2066802 in the detection of tuberculosis susceptibility, can solve problems such as little known

Active Publication Date: 2017-07-07
THE 309TH HOSPITAL OF CHINESE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

Although M. tuberculosis SNP research has achieved world-renowned achievements in methodology and genomics, the relationship between STAT1 gene SNP and the risk of tuberculosis infection in the Chinese population is still poorly understood.

Method used

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  • Application of single nucleotide polymorphism (SNP) rs7576984 and rs2066802 in detecting tuberculosis susceptibility
  • Application of single nucleotide polymorphism (SNP) rs7576984 and rs2066802 in detecting tuberculosis susceptibility
  • Application of single nucleotide polymorphism (SNP) rs7576984 and rs2066802 in detecting tuberculosis susceptibility

Examples

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Embodiment 1

[0038] Example 1. Application of STAT1 gene single nucleotide polymorphisms rs7576984 and rs2066802 in detecting tuberculosis susceptibility

[0039] 1. Patients and groups

[0040] The case-control study involved in the present invention selects 2039 cases of confirmed cases admitted to the No. 309 Hospital of the People's Liberation Army altogether, and is divided into two groups: (1) tuberculosis group: patients who are admitted to the Institute of Tuberculosis of the whole army are clinically treated by imaging studies, experiments 1032 cases of active tuberculosis patients were confirmed by laboratory examination and anti-tuberculosis treatment, including 605 males and 427 females, with an average age of (39.30±19.29) years old. Including pulmonary tuberculosis, tuberculous pleurisy, tuberculous pericarditis, tuberculous meningitis, tuberculous peritonitis, urinary system tuberculosis, bone and joint tuberculosis, lymph node tuberculosis, etc. (2) Non-tuberculosis contro...

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Abstract

The invention discloses application of STAT1 gene single nucleotide polymorphism (SNP) rs7576984 and rs2066802 in detecting tuberculosis susceptibility. The application provided by the invention is the application of a substance for detecting rs7576984 site or rs2066802 site in preparing products for evaluation or auxiliary evaluation of the tuberculosis risk of a to-be-tested patient. The inventor of the invention finds, through a case-control study in Chinese Han population, a significant relationship between the gene polymorphism of STAT1-rs7576984 and rs2066802 sites and tuberculosis affecting risk. The population with STAT1-rs7576984CG genotype and STAT1 'TA' haplotype-formed diplotype has higher risk of tuberculosis in Mycobacterium tuberculosis infection. The invention provides new insight for the association between inflammation and immune related gene SNP and tuberculosis susceptibility, and has a significant value in screening tuberculosis susceptibility genes and preventing tuberculosis.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to the application of STAT1 gene single nucleotide polymorphism rs7576984 and rs2066802 in detecting tuberculosis susceptibility, in particular to STAT1 gene single nucleotide polymorphism (SNP) rs7576984 and rs2066802 site markers Application in screening and assessment of population susceptibility to tuberculosis. Background technique [0002] Tuberculosis (TB) is a global disease that seriously threatens human health, and it has become one of the three major infectious diseases killers of human beings. The World Health Organization's global tuberculosis report pointed out that about 1 / 3 of the people are infected by Mycobacterium tuberculosis, and only 10% of the infected people get sick. This means that whether tuberculosis infection occurs is closely related to the interaction between host and pathogen, environment, genetics and so on. Recently, many studies have demonstrated that TB...

Claims

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Application Information

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IPC IPC(8): C12Q1/68
Inventor 吴雪琼龚文平张俊仙安慧茹梁艳阳幼荣
Owner THE 309TH HOSPITAL OF CHINESE PEOPLES LIBERATION ARMY
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