Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Detection method of traditional Chinese medicine preparation for treating acute infectious hepatitis

A technology of traditional Chinese medicine preparations and detection methods, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of harming the interests of patients, the decline of drug efficacy, and imperfect detection methods, so as to ensure the safety of drugs, protect health, and ensure curative effect Effect

Active Publication Date: 2017-08-04
SICHUAN FENGCHUN PHARMA
View PDF8 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The prescription is a pure traditional Chinese medicine preparation of Yinchen, Danshen, Bupleurum, Imperatae, Radix Radix, Licorice, and Jujube. It is a drug recorded in the second volume of traditional Chinese medicine preparations in the "Drug Standards of the Ministry of Health", and the standard number is WS3-B- 0339-90, named "Compound Danyin Ointment", it has the functions of clearing away heat and dampness, detoxifying and reducing jaundice, and it is clinically used to treat acute infectious hepatitis, but because the detection method of this prescription was formulated in the late 1980s The detection standard was limited by the technical level and detection equipment conditions at that time, and the original detection method was not perfect. In its detection method, except for the detection of general indicators according to the general rules of decoction, there were no other quality monitoring measures, so it could not be well Guarantee the quality of medicines, so that unscrupulous manufacturers may not strictly follow the prescription dosage ingredients when producing medicines, and willfully reduce the raw materials with high prices, resulting in a significant decline in the efficacy of medicines, affecting the safety and effectiveness of medicines, and seriously damaging the interests of patients
[0003] In addition, one of the medicinal materials used in large quantities in prescriptions is Salvia miltiorrhiza, which accounts for a quarter of the total prescription volume. However, Danshen medicinal materials are often counterfeited or mixed into medicines by Gentiana chinensis, which has a negative impact on the quality and efficacy of medicines. Salvia miltiorrhiza is the dry root and rhizome of Labiatae plants. Because the appearance and properties of the two are quite similar, in recent years, it is often found that people tend to confuse the two medicinal materials, but the functions of the two are completely different, and must have Corresponding detection methods to distinguish

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Prescription: Yinchen 240g, Salvia miltiorrhiza 240g, Bupleurum 120g, Imperata 120g, Radix isatidis 120g, licorice 60g, jujube 60g.

[0032] Preparation method: add the above seven flavors, add water and decoct three times, combine the decoction, let stand, filter, concentrate the filtrate to a relative density above 1.30 (thermal measurement), add 240g of sucrose, heat to melt, mix well, concentrate to a relative density of 1.10 ~1.30, that is.

[0033] Properties: This product is brown thick semi-fluid, sweet and slightly bitter.

[0034] Inspection: the relative density is 1.10 to 1.30.

[0035] Composition identification and content determination:

[0036] (1) Identification of components of capillary and Artemisia annua: Take 1g of this product, add 8ml of methanol, ultrasonically treat for 20 minutes, filter, evaporate the filtrate to dryness, add 2ml of methanol to the residue to dissolve, and use it as the test solution; Add methanol to make a solution contai...

Embodiment 2

[0042] In this example, except that step (1) to step (4) in component identification and content determination are different from Example 1, other methods are the same.

[0043] Composition identification and content determination:

[0044] (1) Identification of components of capillary and Artemisia annua: Take 1g of this product, add 12ml of methanol, ultrasonically treat for 40 minutes, filter, evaporate the filtrate to dryness, add 2ml of methanol to dissolve the residue, and use it as the test solution; Add methanol to make a solution containing 0.4mg per 1ml, as the reference substance solution of artemisinin; take the reference substance of artemisinin, add methanol to make a solution containing 0.2mg per 1ml, as the solution of artemisinin reference substance; Take 5 μl of each of the above three solutions, spot them on the same silica gel G thin-layer plate, use 60-90°C petroleum ether: ethyl acetate: acetone = 9:5:3 by volume ratio as the developer, develop and take o...

Embodiment 3

[0050] In this example, except that step (1) to step (4) in component identification and content determination are different from Example 1, other methods are the same.

[0051] Composition identification and content determination:

[0052] (1) Identification of components of capillary and Artemisia annua: Take 1g of this product, add 8ml of methanol, ultrasonically treat for 20 minutes, filter, evaporate the filtrate to dryness, add 2ml of methanol to the residue to dissolve, and use it as the test solution; Add methanol to make a solution containing 0.4mg per 1ml, as the reference substance solution of artemisinin; take the reference substance of artemisinin, add methanol to make a solution containing 0.2mg per 1ml, as the solution of artemisinin reference substance; Take 5 μl of each of the above three solutions, spot them on the same silica gel G thin-layer plate, use 60-90°C petroleum ether: ethyl acetate: acetone = 6:3.5:1.5 by volume ratio as the developer, develop, tak...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a detection method of a traditional Chinese medicine preparation for treating acute infectious hepatitis. As the original detection method is defective, the medicine quality is not well guaranteed, an illegal manufacturer may not mix the medicine materials according to the dosage of the prescription strictly when producing a medicine, relatively expensive raw herbal materials may be reduced randomly, then the curative effect of the medicine is obviously reduced, the safety and the effectiveness of the medicine are affected, and the interest of a patient is seriously damaged. The detection method identifies the ingredients of herba artemisiae scopariae and sweet wormwood herb, the ingredients of radix salviae miltiorrhizae and radix gentianae macrophyllae, and the ingredient of radix glycyrrhizae, and tests the content of tanshinone IIA, then the rare medicinal materials also have clear quality indexes, the quality of the ingredient of the radix salviae miltiorrhizae in the prescription is also effectively monitored, meanwhile, the adulterant sweet wormwood herb of herba artemisiae scopariae and the adulterant radix gentianae macrophyllae of radix salviae miltiorrhizae are also effectively detected, and the condition that the quality and the curative effect of the medicine are affected by the mixing of sweet wormwood herb and radix gentianae macrophyllae is avoided, so that the influences on the human health is avoided, and the safety of the medicine is guaranteed.

Description

technical field [0001] The invention relates to a detection method of a traditional Chinese medicine preparation, in particular to a detection method of a traditional Chinese medicine preparation for treating acute infectious hepatitis. Background technique [0002] The prescription is a pure traditional Chinese medicine preparation of Yinchen, Danshen, Bupleurum, Imperatae, Radix Radix, Licorice, and Jujube. It is a drug recorded in the second volume of traditional Chinese medicine preparations in the "Drug Standards of the Ministry of Health", and the standard number is WS3-B- 0339-90, named "Compound Danyin Ointment", it has the functions of clearing away heat and dampness, detoxifying and reducing jaundice, and it is clinically used to treat acute infectious hepatitis, but because the detection method of this prescription was formulated in the late 1980s The detection standard was limited by the technical level and detection equipment conditions at that time, and the ori...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90G01N30/02
CPCG01N30/02G01N30/90
Inventor 钟茂团何德中温国梁任红
Owner SICHUAN FENGCHUN PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com