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Quality detection method of pharmaceutical composition for relieving cough and asthma

A quality detection method and a technology for relieving cough and asthma, which are applied in the field of medical invention and can solve the problems of lack of heavy metal and harmful element determination, lack of content determination, complicated operation and the like

Active Publication Date: 2021-04-27
贵州大隆药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 1) The identification items of cotton roots, pine cones and loquat leaves are complicated to operate, and the target spots are blurred and poor in reproducibility;
[0007] 2) Lack of determination of heavy metals and harmful elements;
[0008] 3) Lack of content determination of oleanolic acid and ursolic acid in loquat leaves;

Method used

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  • Quality detection method of pharmaceutical composition for relieving cough and asthma
  • Quality detection method of pharmaceutical composition for relieving cough and asthma
  • Quality detection method of pharmaceutical composition for relieving cough and asthma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029][Traffic] This product is granules, the content is light brown particles; sweet, slightly.

[0030][Identification] Take the drug fine powder 5g, ethyl acetate - isopropanol (5: 3) 20 ml, ultrasonic treatment for 25 minutes, filtrate, filtrate, residue, ethyl acetate - isopropyl alcohol (5: 3) 5ml to dissolve, as a solution for the test.

[0031]Take the cotton ribber controlled herbs 1.5g, pine tower controlled medicinal materials 1.5g, luster leaf control 1g, EtOAc (5: 3) 20 mL, ultrasonic treatment for 20 minutes, filtered, filtrate, The residue is ethyl acetate - isopropanol (5: 3) 5 ml to dissolve, as a controlled medicinal solution;

[0032]Take the bear fruit acid gas, add methanol to prepare 1 mg of solution per 1 ml, as a control solution;

[0033]10 μl of the above five solutions were drawn, and the same high-efficiency silica gel G thin laminate was drawn, and ethyl acetate-ethanol-acetone (5: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3...

Embodiment 2

[0046][Traffic] This product is granules, the content is light brown particles; sweet, slightly.

[0047][Identification] After the drug is taken fine, remove the fine powder 4.5 g, ethyl acetate - isopropanol (5: 3) 15 ml, ultrasonic treatment for 20 minutes, filtered, filtrate, residue, residue, ethyl acetate Isopropanol (5: 3) 4 ml to dissolve, as a test solution;

[0048]Take a cotton ribber control drug 1.0g, Song Tower controlled herbs 1.0g, luster leaf control 1.0.8g, EtOAc EtOAc (5: 3) 15ml, ultrasonic treatment for 15 minutes, filtered, filtrate , Residue adding acetate-isopropanol (5: 3) 4 ml to dissolve, as a controlled medicinal solution;

[0049]Take the bear fruit acid gas, add methanol to prepare a solution of 0.8 mg of solution per 1 ml, as a control solution;

[0050]8 μl of the above five solutions were drawn, and the same high-efficiency silica gel g was discharged to an ethyl acetate-ethanol-acetone (5: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: ...

Embodiment 3

[0063][Traffic] This product is granules, the content is light brown particles; sweet, slightly.

[0064][Identification] After the drug is taken, then 5.5 g of the fine powder, ethyl acetate - isopropanol (5: 3) 25ml, ultrasonic treatment for 30 minutes, filtered, filtrate, residue, residue, ethyl acetate Isopropanol (5: 3) 4 ml to dissolve, as a test solution;

[0065]Cotton root controlled herbs 2.0g, P. Pine Tower controlled medicinal materials 2.0g, luster leaf control 1.2 g, EtOAc (5: 3) 25ml, ultrasonic treatment for 25 minutes, filtrate, filtrate , Residue add ethyl acetate - isopropanol (5: 3) 6 ml to dissolve, as a controlled medicinal solution;

[0066]Take the bear fruit acid gas, add methanol to prepare a solution of 0.8 mg of solution per 1 ml, as a control solution;

[0067]The above five solutions were drawn, respectively in the same high-efficiency silica gel G thin laminate, with ethyl acetate-ethanol-acetone (5: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3: 3...

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Abstract

The invention relates to a quality detection method of a pharmaceutical composition for relieving cough and asthma, wherein the pharmaceutical composition is composed of pinecones, cotton roots and loquat leaves; the detection method comprises identification of the active components pinecones, cotton roots and loquat leaves, and determination of oleanolic acid and ursolic acid content in loquat leaves. On the basis of the original quality standard, the identification method is optimized, the detection period is shortened, the detection cost is saved, and the identification for simultaneously detecting pinecones, cotton roots and loquat leaves by using the same thin-layer plate is obtained; in addition, by adding the detection of heavy metals and harmful elements and adding thedetermination of oleanolic acid and ursolic acid content in loquat leaves, the effective components of the medicine are controlled from qualitative detection to qualitative and quantitative detection. The detection method is high in accuracy and good in stability and can be effectively used for controlling the quality of the cough and asthma relieving medicine combination and improving and perfecting the quality standard.

Description

Technical field[0001]The present invention relates to the field of medical invention, and more particularly to a mass detection method for cough asthma composition.Background technique[0002]This product is composed of pine tower, cotton root, loquat leaf; there is a good role in the treatment of pulmonary heat phoracap, cough, blood, and stomach vomiting.[0003]According to the application number CN201811293181.6, the invention is a quality detection method for the treatment of cough thoracic drug combinations, the disclosed quality detection method includes the identification of cotton roots and pine tower, the identification of loquet leaves, of which cotton roots and pine tower The method of identifying 4 to 6 g of the drug is taken, the proportion of ethyl acetate - ethanol is 4: 1, and 15 to 25 ml of ethanol is dissolved, the water bath is heated and refluxed by 30 to 40 min, filtered, filtered water bath and dried, steam The environment is a negative pressure environment of the...

Claims

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Application Information

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IPC IPC(8): G01N33/15G01N1/28
CPCG01N33/15G01N1/28Y02A50/30
Inventor 刘念宁徐卫东聂开品方随换袁仲喜雷冬梅
Owner 贵州大隆药业有限责任公司
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