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Aspergillus ZL01b-14

一种zl01b-14、曲霉的技术，应用在曲霉ZL01b-14。领域，能够解决强副作用、凝血功能和肾功能影响等问题

Inactive Publication Date: 2017-08-29
XIAMEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These two types of drugs have strong side effects while relieving inflammatory diseases, such as long-term use of NSAIDs can lead to gastrointestinal erosion or ulcers and various cardiovascular diseases [7] , coxibs have effects on coagulation and renal function

Method used

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  • Aspergillus ZL01b-14
  • Aspergillus ZL01b-14
  • Aspergillus ZL01b-14

Examples

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preparation example Construction

[0056] The preparation method of described tetracycline aspergillus ketone compound comprises the following steps:

[0057] 1) Prepare a potato-glucose-agar semi-seawater medium plate, transfer Aspergillus sp. ZL01b-14 to the potato-glucose-agar semi-seawater medium, and culture it upside down to obtain plate strains; the potato-glucose - The preparation method of the agar semi-seawater medium is as follows: cut the peeled potatoes into small pieces, add water and boil for 20-40min, filter the potato filtrate with gauze, add glucose, agar and semi-seawater, add water to 1000mL, and sterilize The condition is to sterilize at 121° C. for 20 minutes; the mass ratio of glucose and potato in the potato filtrate may be 1: (10-20), and the mass ratio of agar and potato may be 1: (15-20).

[0058] 2) Inoculate the plate strain obtained in step 1) into a potato-glucose semi-seawater liquid medium for shaker culture to obtain a seed solution; the preparation method of the potato-glucose...

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Abstract

The invention provides aspergillus ZL01b-14, and relates to aspergillus. The aspergillus (aspergillus sp.) ZL01b-14 is preserved in CCTCC (China Center for Type Culture Collection) on December 26, 2014, and has the preservation number of CCTCC NO:M 2014668 in the CCTCC. Four novel-structure tetracycline aspergillus ketone compounds can be obtained through the separation from one strain of alga-associated aspergillus. The cell level anti-inflammatory experiments show that the four compounds have the anti-inflammatory effect and can be applied to the preparation of anti-inflammatory medicine and anti-inflammatory medicine compositions. In addition, the prepared tetracycline aspergillus ketone compounds can also be applied to the preparation of biological active medicine primers.

Description

technical field [0001] The present invention relates to Aspergillus, in particular to Aspergillus sp. ZL01b-14. Background technique [0002] The inflammatory response is part of the body's immune response and is a localized response of blood vessels or tissues to harmful stimuli such as injury or pathogens. The main symptoms of inflammatory reactions are fever, pain, swelling, redness, and loss of body functions, etc., which have varying degrees of impact on the quality of life of patients. Inflammation leads to rheumatoid arthritis, inflammatory bowel disease, neurodegenerative disease, septic shock, atherosclerosis and other diseases [1] , the local chronic inflammatory response can also induce body cancer [2] . [0003] At present, anti-inflammatory drugs have a variety of mechanisms of action, such as blocking the key enzyme cyclooxygenase-2 (COX-2) in the synthesis of prostaglandins related to inflammation, or inhibiting inflammatory factors such as tumor necrosis f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/14C12P17/18A61P29/00C12R1/66
CPCC07D493/04C12P17/181C12N1/145C12R2001/66
Inventor 邓贤明徐庆妍湛莹亓双王跃宙胡志钰郑忠辉宋思扬
Owner XIAMEN UNIV
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