Inhaler, Respiratory Tract and Lung Model Device Integration for Sorting Flower-Shaped Particle Carriers

A technology for respiratory tract and inhaler, applied in the field of particle sorter, can solve the problems of inability to separate, difficult to sort out particles with different shapes, and inability to sort particles with different shapes, etc., so as to improve the preparation process and practicality high sex effect

Active Publication Date: 2019-03-19
江苏道宁药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The prior art records a "particle separator" (application number CN02815701.X), which uses electric field separation equipment to separate the dotted particles in the air. (such as lactose), which are neutral and cannot be separated in an electric field
[0004] The prior art records a kind of "air flow particle sorter and fluidized bed reactor and its application" (application number CN201210420999.6), by changing the guide air outlet, according to the difference in the inertia of particles of different sizes, the particles are sorted out by wind force Large and small particles are better for size separation, but this method cannot separate particles with different shapes
[0005] The prior art records a "Jet Suction Particulate Material Wind Separator" (application number CN201010590628.3), which uses a tapered tube-type sorting pipeline to generate negative pressure to separate heavier particles from the airflow It is better for size separation, but it is also difficult to sort particles with different shapes.

Method used

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  • Inhaler, Respiratory Tract and Lung Model Device Integration for Sorting Flower-Shaped Particle Carriers
  • Inhaler, Respiratory Tract and Lung Model Device Integration for Sorting Flower-Shaped Particle Carriers
  • Inhaler, Respiratory Tract and Lung Model Device Integration for Sorting Flower-Shaped Particle Carriers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Such as figure 1 (Schematic diagram of the structure of the inhaler, respiratory and lung model equipment for sorting flower-shaped particle carriers) As shown in the figure, the integration of inhaler, respiratory and lung model equipment for sorting flower-shaped particle carriers mainly includes inhaler (1), respiratory model Equipment (2), Particle Collector for Respiratory Section Curve (3), Lung Model Equipment (4), Particle Collector for Right Curve of Lung Model (5), Particle Collector for Left Curve of Lung Model (6) ) and air pump (7), the air outlet of the inhaler (1) communicates with the air inlet of the airway model equipment (2), and the middle and lower part of the inner bend of the airway model equipment (2) is connected with the respiratory section bend particle collector (3) The inlet of the airway model equipment (2) is connected to the air inlet of the lung model equipment (4), and the middle and lower parts of the right bends in the airway of the l...

Embodiment 2

[0040]The gas flow rate of the whole system during operation is 30L / min.

[0041] Furthermore, the mixed particle carrier powder to be sorted into the powder inlet (1-1) is mainly composed of flower-shaped lactose particles and lactose monohydrate crystal particles, and the gas entering the inhaler inlet (1-2) is dry room temperature Air, the inhaler grille (1-4) has a side length of 30mm and 100 round holes with a diameter of 2mm.

[0042] Further, the feed valve (3-1) is in an open state, the right first-stage valve (5-1), the right second-stage valve (5-2), the right third-stage valve (5-3), Right fourth stage valve (5-4), left first stage valve (6-1), left second stage valve (6-2), left third stage valve (6-3) and left The fourth-stage valves (6-4) are all closed, corresponding to the coarse separation mode.

[0043] Further, the filter pore size of the particulate filter membrane (4-12) is 1 µm.

[0044] Other processes not listed in Example 2 are the same as those des...

Embodiment 3

[0047] The gas flow rate of the whole system during operation is 100L / min.

[0048] Further, the mixed particle carrier powder to be sorted into the powder inlet (1-1) is mainly composed of rough concave mannitol particles and spherical sucrose particles, and the gas entering the inhaler inlet (1-2) is 15 degrees For dry air, the inhaler grille (1-4) has a side length of 20 mm and has 40 square holes with a side length of 3 mm.

[0049] Further, the grain feeding valve (3-1) is in a closed state, the first-stage valve on the right (5-1), the second-stage valve on the right (5-2), the third-stage valve on the right (5-3), Right fourth stage valve (5-4), left first stage valve (6-1), left second stage valve (6-2), left third stage valve (6-3) and left The fourth-stage valves (6-4) are all opened, which corresponds to the fine separation mode without classification.

[0050] Furthermore, the filter pore size of the particulate filter membrane (4-12) is 0.8 µm.

[0051] Other p...

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Abstract

The present invention provides an equipment integration of an inhaler for sorting flower-shaped particulate carriers, a respiratory tract and a lung model. The equipment integration mainly comprises an inhaler, respiratory tract model equipment, a respiratory segment curve particulate collector, lung model equipment, a lung model right curve particulate collector, a lung model left curve particulate collector, and a sucking pump. According to the technical scheme of the invention, the somatological equipment is creatively adopted and integrated with curve particulate collectors in accordance with the aerodynamics. Therefore, the capability of traditional equipment in separating particulates of different sizes is broken through. On the basis that particulates of different sizes can be sorted, flower shapes and particulates of other shapes can also be sorted. The equipment integration is particularly used for the separation of flower-shaped particulate carriers of dry powder inhalers in mixed particulates. The preparation process of medicine carriers is improved, and the practicability is higher.

Description

technical field [0001] The invention relates to a particle sorter, in particular to an inhaler for sorting flower-shaped particle carriers, respiratory tract and lung model equipment integration. Background technique [0002] The dry powder inhaler carrier is a tool for carrying drug molecules deep into the lungs. Based on the lung trachea structure and physical and chemical properties, the optimal size of the carrier is 1-5 microns, and the flower-shaped or rough spherical shape is preferred. Due to the limited precision of micro- and nano-preparation techniques, the particle carrier produced by crystallization, grinding or other methods often has a normal distribution in shape and size, and the produced particle carrier needs to be sorted. [0003] The prior art records a kind of "particle separator" (application number CN02815701.X), which uses electric field separation equipment to separate the dotted particles in the air. (such as lactose), which are neutral and cannot...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G09B23/28
CPCG09B23/28
Inventor 谭淞文谭松林谭越谭旭
Owner 江苏道宁药业有限公司
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