Ckap4-molecular-targeted antitumor agent

A technology of CKAP4 and anti-tumor agents, which is applied in the direction of anti-tumor drugs, medical preparations containing active ingredients, antibodies, etc., can solve the problems of hyperproliferation and hyperproliferation that have not been reported, and achieve excellent safety and inhibition Proliferation and tumor-specific effects

Active Publication Date: 2017-10-13
OSAKA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the signaling pathway through which Dkk1 leads to hyperproliferation has not been clarified.
[0006] On the other hand, CKAP4 is a transmembrane receptor, and its ligands include anti-proliferative factor (APF), surfactant protein A (surfactant protein A, SPA), tissue plasminogen Activator (tissue plasminogen activator, TPA), etc., any ligand has not been reported to promote cell proliferation mediated by CKAP4

Method used

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  • Ckap4-molecular-targeted antitumor agent
  • Ckap4-molecular-targeted antitumor agent
  • Ckap4-molecular-targeted antitumor agent

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Experimental program
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Embodiment

[0136] Hereinafter, the present invention will be described in detail based on experimental data, but the present invention is not limited by them.

[0137] Note that, hereinafter, transfected cells may be referred to as "X / Y cells" (for example, MDCK / Dkk1-FLAG-GPI cells, etc.), which means that X cells are transduced with DNA encoding protein Y cells after. In addition, a protein may be expressed in the form of "AB" (for example, Dkk1-FLAG, etc.), and this protein refers to a protein in which peptide A is fused to peptide B (tag, etc.). In addition, the transfected cells were produced according to the following production methods or according to known genetic engineering methods in addition to the cells whose production methods are described below.

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Abstract

The purpose of the present invention is to identify a target molecule that is involved in Dkk1-induced hyperproliferation of tumor cells to provide a novel antitumor agent. CKAP4 specifically regulates the hyperproliferation effects that are induced by Dkk1, and proliferation of tumor cells can be suppressed by inhibiting expression or function of CKAP4 in the tumor cells.

Description

technical field [0001] The present invention relates to an antitumor agent. More specifically, the present invention relates to cytoskeleton-associated protein 4 (CKAP4), 63-KDa cytoskeleton crosslinking membrane protein (63-KDa Cytoskeleton-Linking Membrane Protein, CLIMP-63), P63, ERGIC- 63)) An antitumor agent that acts as a target molecule and inhibits the growth of tumor cells by inhibiting the expression or function of the target molecule. Furthermore, the present invention relates to a method for examining the postoperative prognosis of a cancer patient and a method for examining cancer. Background technique [0002] In the Wnt signal transduction pathway, if Wnt, which is an extracellular secreted glycoprotein, binds to the receptor, it will undertake cellular functions via LDL receptor-related protein 5 or 6 (LRP5 / 6) and 7-time transmembrane receptor Frizzled conduction. Signal. Wnt signaling is responsible for the control of diverse cellular functions. Abnormal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/7105A61K31/713A61K39/395A61K48/00A61K49/00A61P35/00A61P35/02G01N33/15G01N33/50
CPCA61K39/395A61K48/00A61K49/00A61K31/7105A61K31/713C12Q2600/118C12N2310/531G01N33/57423G01N33/57438G01N2500/02C12N15/1138C12N2310/14C12Q1/6886C12Q2600/136C12Q2600/158C12Q2600/178G01N33/5011G01N33/5023G01N2333/705A61P1/18A61P11/00A61P35/00A61P35/02A61P43/00C07K16/28C07K16/3023C07K16/303C07K2317/76G01N33/57488G01N33/57492G01N2333/4704
Inventor 菊池章麓胜己木村公一
Owner OSAKA UNIV
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