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Schima superba extract and applications thereof

A technology of extract and lotus root, applied in the field of lotus root extract, can solve the problem of no antibacterial biological activity of the lotus root extract, and achieve the effect of good antibacterial effect

Active Publication Date: 2017-11-21
河北圣奥化妆品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there is no relevant report on the antibacterial biological activity of Schima superba extract

Method used

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  • Schima superba extract and applications thereof
  • Schima superba extract and applications thereof
  • Schima superba extract and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Anti-Candida Albicans Activity of Schima Schiba Extract in Vitro

[0019] In this experiment, sensitive strains of Candida albicans and drug-resistant strains of Candida albicans were used as indicator bacteria, and the antibacterial activity of Schima superba extract was determined by disk method in vitro susceptibility test.

[0020] Schiba Water Extract

[0021] The root bark of Schima superba is properly crushed, sieved through a 40-mesh sieve, 200g is taken, and 500mL of water is added to heat and reflux to extract 3 times for 1 hour each time. The extracts are combined and concentrated under reduced pressure to obtain 18.6g of extract.

[0022] Xylitol Extract

[0023] The root bark of Schima superba was properly crushed, passed through a 40-mesh sieve, 200 g was taken, and 500 mL of 95% ethanol water was added to heat and reflux for extraction 3 times for 1 hour each time. The extracts were combined and concentrated under reduced pressure to obtain 12.3 g of ext...

Embodiment 2

[0031] Dry coarse powder 4.5kg of Schima superba stem, heat and reflux 3 times with 95% ethanol (8 times the amount of medicinal material), each time for 2 hours, combine the extracts for 3 times, and concentrate under reduced pressure to obtain 200g of total extract.

[0032] The total extract was dissolved and dispersed with 50% methanol water, extracted with petroleum ether, chloroform, ethyl acetate and n-butanol in sequence to obtain 50 g of petroleum ether layer, 35 g of chloroform layer, 22 g of ethyl acetate layer and 20 g of n-butanol And the water layer 45g. The ethyl acetate fraction was subjected to silica gel column chromatography in a chloroform-methanol system (100:0; 90:10; 80:20; 70:30; 60:40; 50:50; 30:70; 0:100) to obtain Fr.1 -20 fractions. Wherein fraction Fr.12 (3.3g) is subjected to ODS reverse column chromatography (180g, 3.5cm x 40cm) water-methanol system (80:20; 70:30; 60:40; 40:60; 20:80; 0 :100) to obtain fraction Fr.12-1~13. After preparative o...

Embodiment 3

[0037] 1. Structural identification of the compound sasanquasaponin III (SS-9)

[0038]

[0039] White amorphous powder, (c 0.30, MeOH). Both Liebermann-Burchard and Molish reactions were positive, and the color of concentrated sulfuric acid-vanillin was red (TLC), which was speculated to be triterpenoid saponins. ESI-MS m / z1241.6[M+Na] + , suggesting that the molecular weight may be 1218, combined with 1 H NMR and 13 C NMR spectrum speculates that the molecular formula of compound SS-9 is C 59 h 94 o 26 .

[0040] 1 H NMR spectrum shows 7 angular methyl hydrogen signals [δ H 0.81(3H,s,H-25),1.03(3H,s,H-26),1.08(3H,s,H-29),1.08(3H,s,H-24),1.30(3H,s, H-23), 1.43(3H,s,H-30), 1.85(3H,s,H-27)], 1 ene hydrogen signal (δ H 5.48,br.s), four terminal hydrogen signals [δ H 4.92 (d, J=7.1Hz, H-1′), 5.95 (d, J=7.6Hz, H-1″), 6.19 (d, J=7.0Hz, H-1″′) and 6.26 (br. s,H-1″’)], a set of characteristic angelica acyl hydrogen signals [δ H 1.88(s, H 3 -5″″′), 2.05(d, J=6.6H...

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Abstract

The invention discloses applications of a Schima superba extract in preparation of antifungal drugs or health products or cosmetics, wherein the part of the Schima superba is preferably the root and / or the stem, the extract comprises a water extract or an ethanol extract, and the ethanol is preferably 95% ethanol.

Description

technical field [0001] The invention relates to the field of medicinal materials, in particular to a Schiba superba extract and its application. Background technique [0002] Fungal infection, especially deep fungal infection and fungal drug resistance, is a major problem facing human health and one of the main causes of human disease and death. In recent years, with the widespread use of immunosuppressants, the widespread development of tumor radiotherapy and chemotherapy, especially the increasing number of AIDS patients, the incidence of fungal infections, especially deep fungal infections, has increased sharply [1] . Statistics show that in a tertiary hospital in my country, from 2012 to 2014, the mortality rate due to fungal infection in the hospital reached 12.88%. [2] . Fungal infection has become one of the main causes of death in patients with the above-mentioned immunocompromised critical diseases [1-3] . While antifungal drugs have been widely used clinically...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61K31/704A61P31/10A61K8/9789A61K8/60A61Q17/00A61K125/00A61K135/00
CPCA61K8/602A61K8/97A61K9/0034A61K9/0053A61K31/704A61K36/82A61K2236/333A61Q17/005
Inventor 吴春李黎明王雅英
Owner 河北圣奥化妆品有限公司
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