The invention discloses a camellia Physalosporapiricola prevention and control agent and a preparation method thereof, and relates to the technical field of nursery stock plantation. The camellia Physalosporapiricola prevention and control agent is prepared from, by weight, 15-20 parts of leaf of Schima superba Gardn. et Champ., 15-20 parts of purslane, 10-15 parts of camphor tree leaf, 8-12 parts of tea seed powder, 6-10 parts of heaven tree leaf, 5-8 parts of Chinense Golden Larch Bark, 5-8 parts of perilla leaf, 4-6 parts of mineral powder, 3-5 parts of castor oil, 3-5 parts of licorice root, 2-4 parts of polyoxyethylene lauryl ether, 2-4 parts of lanolin, 1-2 parts of cassia oil, 1-2 parts of copper sulfate and 80-120 parts of water. The prevention and control agent can be directly sprayed on a lesion site in a spray manner, and has the characteristics of fast effectiveness, long drug effect, rapid cure of Physalosporapiricola, provision of nutritional substances for camellia, reduction of influences of disease on camellia, low recurrence rate, and application amount reduction.